Eye Flashcards

1
Q

What is conjunctivitis?

What is the commonest cause?

A
  • Inflammation of the conjunctiva –> a thin layer of tissue that covers to inside of the eyelids and the sclera of the eye.
  • Is the most common eye problem presenting to primary care.
  • Characterised by sore, red eyes associated with a sticky discharge.
  • There are three main types –> Bacterial, Viral, Allergic
  • Adenovirus commonest cause
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2
Q

What is the general presentation of conjunctivitis?

What are the differences in presentation of viral v bacterial conjuncitivitis?

A
  • Unilateral or bilateral
  • Red eyes, blood shot, itchy gritty sensation, discharge from eye
  • DOES NOT cause pain, photophobia or reduced visual acuity. Vision may be blurry when eye covered w discharge but when clear discharge acuity should be normal.

Bacterial
Purulent discharge and inflam conjunctiva
Typically worse in morning –> Eyes may be ‘stuck together’ in the morning
-Usually starts in one eye and can spread to other. Highly contagious.

Viral
Serous (clear) discharge
Recent URTI –> often assoc w other symps of viral infection e.g dry cough, sore throat, blocked nose.
Tender preauricular (in front of ears) lymph nodes
Also contagious.

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3
Q

What are the investigations for conjuncitivitis?

What should you ask when Hx taking? (6)

When should you take swabs?

A

Clinical diagnosis

  • Focused Hx –> evidence recent URTI, whether patient uses contact lenses, Hx eye trauma, occupational exposure e.g chemicals, systemic illness, sexual Hx in young patients
  • Eye examination  check visual acuity, foreign bodies. Pull down lower eye lie to look for follicles/granuloma/discharge
  • Examine for lymphadenopathy
  • Possible eye swab when purulent discharge or suspicion of STIs or herpes conjunctivitis.
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4
Q

What is the conservative management of conjunctivitis?

When would you advise someone to seek urgent further advice?

A
  • Usually self limiting and resolves w/o Tx w/i 1-2 weeks.
  • Advise on good hygiene to avoid spreading (e.g. avoid sharing towels or rubbing eyes and regularly washing hands) and avoiding the use of contact lenses. Cleaning the eyes with cooled boiled water and cotton wool can help clear the discharge. School exclusion not necessary.

-Advise seek urgent medical advice when  loss of vision, photophobia, severe eye redness.

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5
Q

What is the medical management of conjunctivitis?

A

Topical Ab commonly offered when bacterial suspected e.g chloramphenicol drops  1 drop TDS/QDS or when severe given 2-3 hourly, or onitment QDS

  • Topical fusidic acid eye drops is alternative e.g if allergic to chlorampheniol–> use in pregnant women. BD.
  • Those <1 month w conjunctivitis –> urgent opthalmology review as neonatal conjunctivitis can be associated w gonococcal infection and can cause loss of sight and more severe complications e.g pneumonia.
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6
Q

What is allergic conjunctivitis and how is it treated?

A
  • Caused by contact w allergens –> swelling on conjunctival sac and eye lid w significant watery discharge and itch.
  • Bilateral symptoms conjunctival erythema, conjunctival swelling (chemosis)
  • Itch is prominent w possible swelling eyelids.
  • May be a history of atopy
  • May be seasonal (due to pollen) or perennial (due to dust mite, washing powder or other allergens)
  • 1st line –> topical or systemic antihistamines. E.g loratadine. Reduce symptoms.
  • 2nd line –> topical mast-cell stabilisers, e.g. Sodium cromoglicate and nedocromil. Can be used in those w chronic seasonal symptoms. Prevent mast cells from releasing anti histamine.
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7
Q

How would you treat STI related conjunctivitis?

A

Chlamydia conjunctivitis –> ocular tetracycline ointment and systemic doxycycline 100mg BD 1-2 weeks. Or 1g azithromycin stat.

  • Gonococcal w 1.g stat IM ceftriaxone w eye saline wash.
  • Herpes simplex conjunctivitis –> ophthalmology referral. Topical or systemic anti virals.
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8
Q

What are the possible causes of a painless red eye? (3)

A
  • Conjunctivitis
  • Episcleritis
  • Subconjunctival Haemorrhage
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9
Q

What are the possible causes of a painful red eye? (7)

A
  • Glaucoma
  • Anterior uveitis
  • Scleritis
  • Corneal abrasions or ulceration
  • Keratitis
  • Foreign body
  • Traumatic or chemical injury
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10
Q

What is an ectropion and its presentation?

A
  • Out turning of eyelids with the inner aspect of the eyelid exposed. It usually affects the bottom lid.
  • Most common cause old age –> weakening of small muscles around eyelid.
  • Other causes –> trauma or scarring of eyelid. Facial paralysis and facial weakening can lead to ectropion.
  • Ectropion à can result in exposure keratopathy as the eyeball is exposed and not adequately lubricated and protected.
  • Usually unilateral, can be bilateral.
  • Can be severe w whole length eyelid turned outwards
  • Epiphora –> excessive watering, more tears produced to protect cornea w cornea irritated.
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11
Q

What are the investigations and management for an ectropion?

A

Clinical diagnosis

  • Conservative –> Avoid lid rubbing as causes dryness and irritation. Horizontal taping at night and during day
  • Medical –> Regular eye drops à Hypermellose 0.3% lubricating for cornea
  • More severe cases may require surgery to correct defect à Refer to opthalmologist for surgical repair when continuing to persist and to prevent conjunctivitis and keratitis.
  • A same-day referral to ophthalmology is required if there is a risk to sight.
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12
Q

What is an entropion and its presentation?

A

Inturning of eyelids inwards with the lashes against the eyeball.

  • Results in pain and can result in corneal damage and ulceration.
  • Associated a weak ocular muscles in old age.
  • Can occur due to eyelid trauma or infection.

-Watery eyes, Painful.

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13
Q

What are the investigations and management for an entropion?

A

Investigations
Clinical diagnosis. Swabs when discharge or signs infection.

Management

  • Initial management à taping the eyelid down to prevent it turning inwards. Need to prevent eye drying out so also regular lubricating drops w hypermellose.
  • Definitive management is with surgical intervention à Surgical referral if above not working or severe symptoms.
  • A same-day referral to ophthalmology is required if there is a risk to sight.
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14
Q

What are cataracts?

What are the various causes?

What happens when left untreated?

A

-Common eye condition –? gradually the lens of eye opacifies –> a cloudy area forms within the lens and can reduce transparency of the lens. This makes it more difficult for light to reach back of eye (retina) therefore  reducing  visual acuity w reducing/blurred vision. 
-A leading cause of curable blindness.  
-Cataract can form in one or both eye at any age.  
-Most occur as result of ageing most common >60. 
-RF –> FH age related cataracts, corticosteroid treatment, smoking, prolonged exposure UVB light, ?alcohol, hypocalcaemia.  

Other causes 
-Trauma  e.g eye injury or operation 
-Eye disease  e.g chronic anterior uvetitis, acute congestive angle closure glaucoma, retinitis pigmentosa. 
-Systemic disease  e.g diabetes, neurofibromatatosis type 2, severe atopic dematitis  
-Congenital and developmental cataracts in children. Occur before birth, screened for using red reflex during neonatal examination. 

  • Untreated –> most people with a cataract will become severely visually impaired. With surgery, 95% of people will have 6/12 best-corrected vision if there is no other pre-existing ocular copathology. 
  • Untreated congenital cataracts in babies cause deprivation amblyopia –> serious lifelong visual impairment,
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15
Q

What is the typical presentation of cataracts?

A
  • Symptoms are usually  asymmetrical as both eyes are affected separately. 
  • Gradual onset, very slow reduction in vision –> main symptom gradual and painless reduction in visual acuity can present as gradulal difficulty reading, recognising faces. 
  • Progressive blurring of vision 
  • Change of colour of vision with colours becoming more brown or yellow – increasing difficulty w distinguishing colours  
  • “Starbursts” can appear around lights, particularly at night time 
  • Glare w lights appearing brighter than normal or difficulty seeing in presence of bright light can be dominant symptom at first. E.g difficulty seeing in brought sun or driving at night w oncoming bright headlights. 
  • Key sign –> Loss of red reflex. Lens can appear grey or white. Red reflex usually red orange reflection seen through opthalmosocpy when light shone into retina. Cataracts prevent light reaching retina.  
  • Can be –> white or grey pupil (leukocoria),  invol  eye  movements (Nstagmus), squint (strabismus)
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16
Q

What are the DDx of cataracts and their differentiating factors?

A
  • Cataracts cause a generalised reduction in visual acuity with starbursts around lights.  
  • Glaucoma causes a peripheral loss of vision with halos around lights.  
  • Macular degeneration causes a central loss of vision with a crooked or wavy appearance to straight lines. 
17
Q

What are the investigations for cataracts?

A
  • Opthalmoscopy –> done after pupil dilation. Opacity can be seen in lens (can range from small dot to complete opacification) w reduced or obliterated red reflex.  Normal fundus and optic nerve. 
  • Slit lamp examination, visible cataract. 
  • Should encourage to have eye examination by optometrist –> accurately assess visual acuity, exclude other causes visual impairment.  
18
Q

What is the management for cataracts?

A

-If the symptoms are manageable then no intervention may be necessary. 
-For babies and children with suspected cataract — urgent referral to an ophthalmologist should be arranged. 

Non-surgical 
-In the early stages, age-related cataracts can be managed conservatively by prescribing stronger glasses/contact lens, or by encouraging the use of brighter lighting.  
-These options help optimise vision but do not actually slow down the progression of cataracts, therefore surgery will eventually be needed. 

Surgery 
-The only effective treatment for cataracts.  
-This involves removing the cloudy lens and replacing this with an artificial one.  
-Cataract surgery has a high success rate with 85-90% of patients achieving 6/12 corrected vision (on a Snellen chart) postoperatively. 
-NICE –> referral for surgery should be dependent upon whether a visual impairment is present, impact on quality of life, and patient choice. Also whether both eyes are affected and the possible risks and benefits of surgery should be taken into account.

19
Q

What is optic neuritis?

What is the most common cause?

What are other associated causes?

A
  • Inflammation of the optic nerve.

- Causes à MS is the commonest associated disease, also diabetes, syphilis.

20
Q

What is the typical presentation of optic neuritis?

A
  • Classically triad –> reduced vision (of varying severity), eye pain (particularly on movement) and impaired colour vision.
  • Unilateral decrease in visual acuity over hours/days
  • Pain worse on eye movement
  • Poor discrimination of colours ‘red desaturation’
  • Relative afferent pupillary defect
  • Central scotoma à aura/blind spot that blocks part of vision.
21
Q

What are the investigations for optic neuritis?

A
  • Clinical diagnosis
  • Full ophthalmic examination w testing acuity, contrast, colour, visual fields.
  • Neurological examination
22
Q

What is the management for optic neuritis?

A
  • ?refer to ophthalmologist and or neurologist.
  • Ophthalmologist involved in initial assessment, diagnosis and Tx. Further management regarding risk MS to neurology.
  • High dose corticosteroids during the acute phase –> methylprednisolone speeds up recovery but no effect on final acuity.
  • Methylprednisolone 1 g daily for three days.
  • Recovery usually takes 4-6 weeks.
23
Q

What is a chalazion?

A
  • A chalazion (Meibomian cyst) is a retention cyst of the Meibomian gland.
  • Occurs when meibomian gland becomes blocked and swells up –> sterile chronic inflamm granuloma of eyelid caused by foreign body reaction to sebum w/i meibomian gland.
  • Freq cause of lumps on eyelid.
  • Pregnant women and people w blepharitis, rosacea, diabetes, high cholesterol, sebhorrheoic dermatitis are at increased risk.
24
Q

What is the presentation of a chalazion?

What are the investigations?

A
  • Typically –> firm painless lump in eyelid –> localised eyelid swelling. Can be tender and red.
  • Develops slowly over several weeks.
  • More common on upper eyelid, 2-8mm, one or both eyes can be affected, >1 can be present.
  • When the eyelid is everted, there is a discrete, immobile nodule (granuloma).

-Clinical diagnosis

25
Q

What is the management of a chalazion?

A
  • Majority resolve spontaneously.
  • Hot compress –> e.g clean flannel rinsed w hot water for 10-15 mins after which gently massage cyst to aid expression of contents. Repeated up to x5 day several weeks.
  • Analgesia
  • Ab not routinely recommended. ?topical chloramphenicol when acutely inflamed.
  • Rarely surgical drainage required.
  • Hospital admission required if there are symptoms and signs of significant periorbital or orbital cellulitis. Both may present acutely with a firm, warm, tender, erythematous, oedematous eyelid.
  • Referral to an ophthalmologist should be made if the meibomian cyst is affecting vision, causing discomfort (especially if it is large and hard), is cosmetically unacceptable, or if there is no response to conservative treatment.
26
Q

When should you suspect a malignant eyelid tumour?

A
  •  A lesion  has an ulcerated or atypical appearance, or recurs in the same location).
  • Urgent referral
27
Q

What is blepharitis?

A
  • Inflammation of the eyelid margins.
  • Can be due to dysfunction of meibomian glands –> responsible for secreting oil onto surface of eye which prevent rapid evaporation of tear film. Posterior blepharitis.
  • Or can be due to seborrhoeic dermatitis/staph infection –> anterior blepharitis. Less common.
  • More common in those w rosacea.
28
Q

What is the presentation of blepharitis?

A
  • Any problem affecting meibomian glands –> can cause drying or eyes and irritation
  • Gritty, itchy dry sensation in eyes.
  • Eyelid margins can be red. Possible swollen eyelids when staph infeciton.
  • Usually bilateral.
  • Eyelids can be sticky in mroning.
  • Can lead to chalazions and styes.
  • Possible secondary conjunctivitis.

-Clinical diagnosis

29
Q

What is the management of blepharitis?

A
  • Hot compresses and gentle cleaning (mechanical removal of debris from lid margins) –> cotton wool buds in cooled boiled water w baby shampoo.
  • Alternative is sodium bicarb –> teaspon in cup cooled water.
  • Lubricating eye drops –> symptoms relief in those w dry eyes. Hypromellose least viscous. Polyvinyl alcohol in middle (start). Carbomer most viscous.
30
Q

What is orbital cellulitis?

A
  • The result of an infection affecting the fat and muscles posterior to the orbital septum, within the orbit but not involving the globe.
  • Usually caused by a spreading URTI from the sinuses and carries a high mortality rate.
  • A medical emergency requiring hospital admission and urgent senior review.
  • Most common bacterial causes – Strep, Staphylococcus aureus, Haemophilus influenzae B.
  • Average age hospitalisation 7-12 years.
  • RF –> previous sinus infection, lack Hib vaccination, recent eyelid infection/insect bit on eyelid (peri orbital cellulitis), ear or facial infection.
31
Q

What are the differences between orbital and peri orbital cellulitis?

A

Periorbital cellulitis

  • an eyelid and skin infection in front of the orbital septum (in front of the eye).
  • results from superficial tissue injury e.g chalazion, insect bit.
  • Can progress to orbital.
  • Presents with swelling, redness and hot skin around the eyelids and eye. 
  • Treatment is with systemic antibiotics (oral or IV). Preorbital cellulitis can develop into orbital cellulitis so vulnerable patients (e.g. children) or severe cases may require admission for observation while they are treated.

Orbital Cellulitis

  • An infection around the eyeball that involves tissues behind the orbital septum.
  • Key features that differential this from periorbital celluitis is –> pain on eye movement, reduced eye movements, changes in vision (reduced acuity), abnormal pupil reactions and forward movement of the eyeball (proptosis).
32
Q

What is the presentation or orbital cellulitis?

A
  • Redness and swelling around eye.
  • Severe ocular pain, visual disturbance. Proptosis (protrusion eye ball same as exophthalmos).
  • Ophthamoplegia (paralysis/weakening eye muscles)/pain w eye movements
  • Eyelid oedema and ptosis.
  • Drowsiness, nausea, vomiting when meningeal involvement (not common)
33
Q

What are the investigations for orbital cellulitis?

A
  • FBC –> WBC elevated, raised inflammatory markers.
  • Clinical examination à complete ophthalmological assessment – Decreased vision, afferent pupillary defect, proptosis, dysmotility, oedema, erythema.
  • CT with contrast – Inflammation of the orbital tissues deep to the septum, sinusitis. HELP TO DIFFERENTIATE PERIORBITAL v ORBITAL.
  • Blood culture and microbiological swab to determine the organism.
34
Q

What is the management for orbital cellulitis?

A
  • Urgent admission ophthalmology –> IV antibiotics.

- Surgical drainage when abscess

35
Q

What is open angle glaucoma?

A
  • Optic nerve  damage that is caused by a significant rise in intraocular pressure. The raised intraocular pressure is caused by a blockage in aqueous humour trying to escape the eye.
  • Commonly associated w raised intraocular pressure and characterised by visual field defects and changes to optic nerve head (e.g patho cupping or pallor optic disc).
  • Can be classified as whether peripheral iris is covering trabecular meshwork (important for drainage of aqueous humour from anterior chamber eye).
  • Open angle –> iris clear of network. Trabecular network func offers increased resistance to aqueous outflow causing increasing IOP.
  • Typically associated w raised IOP which damages optic nerve fibres, can occur in some w normal IOP.
  • RF –> increasing age 2% >40 10% >80, FH, black ethnicity, near sighted (myopia), HTN, diabetes, corticosteroids.
36
Q

What is the presentation of open angle glaucoma?

A
  • Often detected at routine optometry appointments.
  • Insidious in onset, chronic course –> rise in intraoc pressure asymp for long time.
  • Typically affects both eyes.
  • Can present w gradual onset fluctuating pain, headaches, blurred visions, halos round lights (particularly at night).
  • Effects peripheral vision first, gradually closes in until get tunnel vision. Decreased acuity.
37
Q

What are the investigations for open angle glaucoma?

What is the typical triad of signs w/I eyes?

A
  • GP –> suspect when person w visual field defect w/o other eye symptoms or when ophthalmoscopy reveals cupped optic disc in one/both eyes. Refer to optometrist and then subsequently ophthalmologist.
  • Usually made by optometrist at routine appointments –> then refer to ophthalmologists to confirm via GP.
  • Fundoscopy signs of primary open-angle glaucoma (POAG).
  • Typical –> increased intraoc pressure, visual field defects, optic disc cupping.

Diagnosis

  • Goldmann applanation tonometry à check intra oc pressure. >24mmHG.
  • Fundoscopy à optic disc cupping. Nerve head damage under slit lamp.
  • Visual field assessment à visual field defect.
38
Q

What is the management of open angle glaucoma?

What is 1st line? What are the SE of the 1st line treatment?

What are possible 2nd line options?

A
  • Aim to reduce intraoc pressure. Tx started when pressure 24mmHG and above. Follow up closely to assess response treatment.
  • 1st line –> prostaglandin analogue eye drops à iatanprost. Increase uveoscleral outflow and lower intraoc pressure which prevents progressive loss visual field. SE à eyelash growth, eyelid pig, and iris pig (browning)
  • 2nd line –> BB (timolol avoid asthma and heart block), carbonic anyhydrase inhibitor (dorzolamide), sympathomimetic (brimonidine, avoid MAO and TCA). All reduce production aqueous humour.
  • More advanced/eye drops ineffective à trabulectomy surgery. Create new channel from anterior chamber.