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Embryo 2 > Eye > Flashcards

Eye Flashcards

1
Q

Corneal stroma/endothelium
Choroid and sclera (w/meso)
iris stroma
connective tissue of extra ocular muscles

ciliary muscle are from…

A

Neural crest cells of the head mesenchyme

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2
Q

Optic nerve, retina, Iris muscles, RPE, vitreous humor

derive from

A

Neuroectoderm

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3
Q 
Lens
cornea
conjunctiva/caruncle
eyelid
lacrimal gland and drainage are from..
A

suface ectoderm

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4
Q

Week eye development begins

A

week 4

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5
Q

optic pits

A

inward bulges of ectoderm on either side of neural tube

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6
Q

optic vesicle

A

increase in cell proliferation leads to large spherical bilge connected to neural tube by a thin optic stalk (all still ectoderm) (~25days)

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7
Q

What induces formation of the lens/ derived from?

A

optic vesicle, made from ectoderm. Lens placode develops here (starts as lens vesicle and then is filled in with cells) (lens=ectoderm)

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8
Q

When an eye is formed with no lens, what else may be present?

A

Microopthalmia or anophthamia

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9
Q

Optic cup

A

Invagination of lens placode, asymmetric with a deep groove on inf. surface (choroid fissure)

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10
Q

Artery that runs through the choroid fissure on the inferior aspect of the optic cup

A

Hyaloid artery (embryonic structure), but will become the central retinal artery

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11
Q

What cell types fill up the lens vesicle?

A

anterior lens cells- cuboidal, single layer
posterior lens cells- multiply and elongate
outermost cells- lens capsule

*newer (secondary) fibers are laid over pre-existing (primary), therefore the oldest cell fibers in center and newest at equator

**first ocular structure to show cellular differentiation

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12
Q

35% of the protein in the lens

A

cristallin

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13
Q

Precursors of retina, optic nerve, lens, and cornea are present by what week?

A

week 6 (develops from inside to out)

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14
Q

Incomplete closure of choroidal fissure creates…

A

Colobomas- incomplete, improperly formed, or depigmented segments in iris, lens, choroid, retina, ciliary body (can be associate w/ microopthalmia)

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15
Q

What is the first retina layer to differentiate?

A

Retinal pigment epithelium. week 3-4

@ week 6- RPE is one cell thick

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16
Q

Major events of week 4

A

Eye development , including RPE

17
Q

Major events of week 5

A

Lens development begins and Choroid fissure begins to close . corneal differential complete

18
Q

Major events of week 7

A

Choroid fissure is closed, and 2 layer of optic cup are formed (outer- RPE, NPE of ciliary body, ant. iris/ Inner- neural retina, inner NPE of cb, post. iris)

19
Q 
sclera and choroid(w/NC)
vitreous humor 
blood vessels 
extra ocular muscles
pia, arachnoid, and dura of optic nerve
A

Mesoderm of head mesenchyme

20
Q

Congenital cataracts cause

A

Rubella, lens is opaque or white

21
Q

Optic stalk

A

Connects the forebrain and the optic vesicle, will become the optic nerve

22
Q

Week 8

A

ganglion and amacrine cells

23
Q

Week 12

A

phtotreceoptors and synapses

24
Q

6 months

A

cell density in the macula, dural layers around optic nerve (5-7 mo)

25
Q

How do neural crest cells migrate in to form the cornea?

A

33 days- Between the surface ectoderm and lens vesicle
first wave- endothelium

Week 8- Between developing end and ectotheilium
second wave- stroma and pupillary membrane
- splits into ant and post
Anterior- stroma and endothelium of cornea
Posterior- Stroma of the iris

26
Q

Sclera formation?

A

Condensation of the mesenchyme around the optic cup, Anterior first (week 5) Muscles attach by week 12

27
Q

Ciliary body formation?

A

formed by neural crest cells by month 3

Ciliary epithelium produces zonular fibers

28
Q

What is the Hyaloid system?

A

the hyaloid artery, mesenchyme derived, degenerates by 3-4 months. This artery produces a network that feeds the developing lens, through the tunica vaculosa lentis.

29
Q

What are the derivatives of the ventral and dorsal ophthalmic arteries in the adult?

A

ventral o.- medial long posterior ciliary artery

dorsal o. - temporal long posterior ciliary and the short posterior ciliary

30
Q

What are the upper and lower lids developed from?

A

Upper- frontonasal process

Lower- Maxillary process

Embryo 2 (4 decks)

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