Extra things Flashcards
Role of FLT3
Tyrosine kinase drives CXCL12 production
Role of CXCL12
Controls pre-pro B cell anchoring in correct stromal niche
Role of Il-7
Required for lineage progression
Role of Cell adhesion molecules
assist cell anchoring
Role of cKIT/SCF (stem cell factor)
interaction induces intracell signalling pathways to drive B cell development
Where in the BM does haematopoesis occur?
in the extravascular spaces between the sinuses
Progression of B cell markers
- B220
- CD19
- IgM
- IgD
In which cells does heavy-chain gene rearrangement occur?
Pro- B cells
In which cells does Light-chain gene rearrangement occur?
Pre-B cells
Role of CD21 on mature B cells
Activation of B cells by complement
Components of B cell co-receptor
- CD21
- CD19
- CD81
What happens in the dark zones of lymphoid tissue?
- clonal expansion
- somatic hypermutation
What happens in the light zone of lympoid tissue?
- selection
- class switching
- differentiation
Describe migration of B cells to T zone and follicles
- HEV and stromal cells secrete CCL21
- DCs migrate and secrete CCL21 and CCL19 which attract B and T cells
- B cells induce follicular DCs to secrete CXCL13 to attract more B cells
Factors influencing gut microbiota
- mode of fetus delivery
- geographic origin
- host genotype
- diet
- antibiotics
- probiotics
- age
- stress
