Extra drug box information (4-6)

Question 1

IV Acetaminophen is called?

Answer 1

Ofirmev

Question 2

Ofirmev classification?

Answer 2

Non-opioid analgesic, antipyretic

Question 3

antidote for Ofimev overdose?

Answer 3

acetylcysteine

Question 4

Dose of Ofimev for adults over 50kg?

Answer 4

1 gm over 15 min. q 4-6 hours.

Question 5

Dose of Ofirmev for an adult under 50kg?

Answer 5

15mg/kg 4-6 hours, not to exeed 3gm/day

Question 6

max dose per day of Ofirmev for adult over 50kg?

Answer 6

do not exceed 4g/day

Question 7

Contraindications to Ofirmev?

Answer 7

Hepatotoxicity in individuals with impaired liver function. Hepatotoxicity seen in chronic alcoholics.

Question 8

MOA of Ofirmev?

Answer 8

It has a central analgesic effect that is mediated through activation of descending serotonergic pathways. It also produces inhibition of prostaglandin synthesis. Spinal cord level it antagonizes neuro transmission by N-methyl-D-asparate substance P, (NMDA) and nitric oxide pathways.

Question 9

Elimination of IV Acetaminophen?

Answer 9

it is eliminated by hepatic elimination by conjugation to either the glucuronide which is (55%) or sulfate which is (25%) less than 10% is oxidized by CYP2E1, 3A4 and isozymes to N-acetyl-p-benzoquininone (NAPQ1) metabolite. Which is excreted by the kidney at 1-4%.

Question 10

Ofirmev Onset, peak, duration?

Answer 10

onset: 2.5min
peak: 2 hours
duration: 2-6 hours