Extra Anti-Arryhthmics Flashcards
What do you not give class IV with and why
Digoxin
Dofetilide
Simvastatin
Lovastatin
What does Digoxin do
Shorten refractory in atrial and ventricular myocardium
Lengthen refractory and lower conduction in AV node
When do you give Digoxin
A-fib/flutter with impaired LV function or HF
Direct action of Digoxin
AV node blocking
Activate Ach-mediated K currents in atrium
Indirect effects of Digoxin
Hyperpol
Shorten atrial AP
Increase AV refractory
Effect of Digoxin toxicity
V-tach
V-fib
Which miscellaneous antiarrhythmic is given in IV form
Adenosine
What is the DOC for abolishing acute SVT in emergency
Adenosine
Which antiarrhythmic is a P1r agonist
Adenosine
What does high dose Adenosine do
Decrease conduction velocity
Prolong refractory
Decrease AV automaticity
How does Adenosine act
Increase K conduction
Decrease Ca influx leading to hyperpol
What are the AE for Adenosine
Chest pain similar to MI
Hypotension
Bronchoconstriction in asthmatics
What is a functional Ca antagonist
Mg
What is used in bradyarrhythmia to decrease vagal tone and increase HR
Atropine
When is Mg used
Torsades de Pointes Digitalis arrythmias (also lidocaine) Arrhythmia prophylaxis in acute MI
When is Atropine used
Bradyarrhythmia
What is the most common clinical arrhythmia
A-fib
What drugs are involved in Rhythm control of A-fib
Class IC
Class III
IA (more AE)
What drugs are involved in Rate control of A-fib
Ca channel blockers
Beta blockers
Digoxin
When do you use IV Heparin to control thromboembolic events in A-fib
Unstable pts needing immediate cardioconversion
When do you use oral Warfarin to control thromboembolic events in A-fib
If cardioversion can be delayed 3-4 days
