Class III's

Question 1

What do III block

Answer 1

K channel Ventricular and Supraventricular

Question 2

What are the III drugs

Answer 2

Amiodarone Sotalol Dofetilide

Question 3

How do III act

Answer 3

Prolong AP and QT and refractory No effect on phase 0 Can induce Arrhythmias

Question 4

Class III that is a pure K blocker

Answer 4

Dofelitide

Question 5

Structurally related to thyroxine

Answer 5

Amiodarone

Question 6

Which Antiarrhythmic has class I, II, III, IV effects

Answer 6

Amiodarone

Question 7

What is the most common antiarrhythmic

Answer 7

Amiodarone

Question 8

What is low dose Amiodarone used for

Answer 8

Maintain normal sinus in A-fib

Question 9

How long does it take for full clincal AE of Amiodarone to be apparent

Answer 9

6 weeks

Question 10

Effects of Amiodarone

Answer 10

Decrease AV conduction and sinus node function Block inactivated Na channels Weak Ca blocker Inhibit adrenergic stimulation Anti-anginal

Question 11

How common are Amiodarone AE

Answer 11

> 50% of people

Question 12

Notable AE of Amiodarone

Answer 12

IPF Blue/Gray skin discoloration (Iodine accumulation) Thyroid dysfunction

Question 13

What is Amiodarone never coadministered with

Answer 13

Digoxin Theophylline Warfarin Quinidine

Question 14

When do you never give Amiodarone

Answer 14

Bradycardia SA/AV block Severe hypotension Resp failure

Question 15

What kind of a drug is Sotalol

Answer 15

Non-selective Beta-blocker

Question 16

Which drug is the delayed K channel rectifier

Answer 16

Sotalol

Question 17

What do you NOT use Sotalol for

Answer 17

Asymptomatic arrhythmias

Question 18

Class III with least AE

Answer 18

Sotalol

Question 19

Main AE in Sotalol

Answer 19

Torsades de pointes (prolong QT) Caution in renal impairment

Question 20

AE for Dofetilide

Answer 20

HA, chest pain, Dizziness, V-tach TORSADES DE POINTES

Question 21

What drugs are involved in Rhythm control of A-fib

Answer 21

Class IC Class III IA (more AE)