Extra

Question 1

CA19-9

Answer 1

Cholangiocarcinoma
Pancreatic adeno

(also colorectal, gastric, non neoplastic - pancreatitis, hepatitis, cholecystitis, non-hepatopancreatic conditions)

Question 2

CEA

Answer 2

Colorectal cancer

Others: pancreas, stomach, cholangio, lung, breast, medullary thyroid, ovarian, smoking, hypothyroid, IBD, cirrhosis, COPD, pancreatitis

Question 3

Caroli disease

Answer 3

Associated with MSK, ADPKD, ARPKD
AR
Increased risk of cholangiocarcinoma

Question 4

Caroli syndrome

Answer 4

Caroli disease + hepatic fibrosis and portal hypertension

Question 5

Hepatomegaly

Answer 5

>15.5 midclavicular line
Malignancy
Extramedullary haematopoiesis
Mastocytosis
Fat
Amyloid, sarcoid
Veno-occlusive disease
PBC
R heart failure
Glycogen storage, haemachromatosis, Gauchers

Question 6

Splenomegaly

Answer 6

Haematological (e.g. malignancy, extramedullary haematopoiesis)
Haemodynamic (cirrhosis, PV thrombosis, congestion)
Infection (esp EBV)
Storage diseae - Gaucher, glucogen storage, MPS
Infiltrative - sarcoid
Neoplastic
Trauma
Connective tissue e.g. Feltys RA, SLE

Question 7

Cirrhosis

Answer 7

End stage liver disease with necrosis, fibrosis, nodular regeneration
Alcohol - 70%
Hep - 10%
NASH - 10%
Biliary - PSC, PBC - 5-10%
Metabolic - haem, Wilsons, alpha-1 - 5%
Vascular - congestive, Budd-chiari
Autoimmune
Meds