Externalising Disorders Flashcards
Four disorders
o Conduct disorder
Adult – antisocial personality disorder
o Attention Deficit Hyperactivity Disorder
o Oppositional Defiant Disorder (lower level CD)
Common features of ODD and CD
o Breaking rules
o Argumentative
o Often aggressive
o Note
More than typical for age
CD takes precedence over ODD – can’t have both
Differences between ODD and CD
o ODD
More argumentative
Often touchy and angry
Often in one setting (e.g. home)
o CD
More social violations
More “severe” behaviours (e.g. fire setting, use of weapons)
Typically across settings
Often engages peers
• Core features of ADHD
o Difficulty with appropriate attentional focus and/or control over activity levels
o Must be more than typical for age
o E.g. unable to sustain attention, follow tasks, organise activities
o E.g. unable to sit still, wait turn, stay quiet
• Prevalence of externalising disorders in children
o Difficult diagnoses and very arbitrary cutoffs. Therefore rates vary widely. Around 10% of kids
o Great Smokey Mountains study
3% ODD
3% CD
1% ADHD
• Comorbidity
o Very high between each other – lots of overlap
o Depression
Difficulty with school, peers
o Anxiety – mostly ODD
CD may be protected
o Substance use – mostly CD
o Learning difficulties, MR
• Age and Gender
o Mostly male disorders
Especially CD – 4x
ADHD – 3-4x
Less ODD – 1.5-2x
o Disorders of childhood onset
ADHD by definition before age 7
ODD usually early childhood
CD mid/late childhood – rare after 16
• Social/personal correlates
o Academic difficulty/failure
o Truancy
o Peer rejection
o Association with similar peers (esp. CD)
o Family conflict
o Risky behaviours
o Unemployment, marginalisation, prison
• Antisocial personality Disorder
o Adult “version” of CD
o Violation of social and personal rights and rules
o Early history of CD
o Continued characteristics such as fighting, breaking law, deceitfulness, lack of remorse
• Characteristics of ADP
o Up to 2% of pop
o Largely male
o Tends to decrease with age
o Inconsistent work history
o History of fights, aggression, and risky behaviour
o Common comorbid substance abuse and mood disorders
o Common prison history
• Psychopathy vs. APD
o Psychopathy part of earlier systems – dropped in DSM=IV
o Limited affect
o Lack of remorse
o Self-gain focus
o ADP – involves antisocial behaviours e.g. fighting
o Can there be successful psychopaths?
• Much more likely to have future problems following ADHD
o 12x ODD
o 10x anxiety depression
o 3x impairment
o 2x juvenile justice
• Genetics - ADHD
o Risk for ADHD 2/8x greater among 1st degree relatives
o Twin studies – mean heritability - .76
o Specific candidate genes related to DA, NA and 5HT systems – strongest evidence related to DA receptors and DA transport
• Genetic factors in externalising behaviours
o Family concordance – especially in fathers, mothers often depressed
o Twin studies show strong evidence for heritable component – 50%
o Considerable evidence for GxE interactions
o Some hints that psychopathy might be more heritable than antisocial behaviour
• Biochemistry of ADHD
o Simple DA theory proposed by Levy (1991)
o Low levels of DA in striatum and frontal cortex
o More recent variations predict more complicated effects
o Complex influence of NorAdrenaline on DA