export_viral stis i Flashcards
Sexually transmitted viruses
HIV
HSV
HPV
Hepatitis
Components of the HIV virus
Envelope
Matrix
Nucleocapsid
Genome
HIV life cycle
gp120 binds to CD4
Conformational change in gp120 allows for binding to CCR5 or CXCR4
HIV coreceptors
R5-tropic HIV binds to CCR5
X4-tropic HIV binds to CXCR4
HIV - gp41
Mediates fusion between viral envelope and the plasma membrane
HIV - pol gene
Virally encoded enzyme within the virion that produces a linear dsDNA copy of the RNA HIV genome
High error rate, allows for rapid evolution during course of the disease
HIV - integration
dsDNA copy is incorporated into the host genome and is transcribed by the host as long as the cell survives
Viral integrase
Enzyme that incorporates the viral DNA copy into the host genome
Provirus
The viral DNA that is incorporated into the host genome
HIV - egress
HIV virions exit cell by budding through the plasma membrane at lipid rafts
HIV - maturation
Viral protease cleaves the gag and gag-pol viral polyproteins
Necessary for infectivity of the virus
Acute HIV syndrome
Approximately 3-6 weeks following infection
Symptoms similar to mono
May not have detectable levels of anti-HIV
HIV - chronic phase
Low level viremia due to viral replication
Patient’s often asymptomatic (can be latent for ~10 years)
How does HIV evade the immune system in the chronic phase?
Ag drift of gp120
Inactivation of the key elements of the immune response
Cell-to-cell fusion
HIV to AIDS
Reduction of CD4 cells
Copious budding and interference with cellular processes