Explanations for OCD Flashcards
1
Q
Genetics
A
Tends to run in families
LEWIS - 37% pt w/ OCD have parents w/ OCD, 21% siblings
2
Q
Twin studies
A
Nestadt et al
- meta analysis
- 68% MZ
- 32% DZ
3
Q
Candidate genes
A
- SERT gene- 5HT1-D beta gene transports seretonin across synaptic gap
- COMT gene regulates the neurotransmitter dopamine
4
Q
Genetic - AO3
A
- likely to be polygenic = up to 230 genes involved
- not 100% concordance - other factors
5
Q
Neurotransmitters
A
- low levels of seretonin leads to abnormal functioning of orbito frontol cortex and caudate nucleus (decision making)
- high levels of dopamine leads to compulsive behaviours as dopamine is a rewarding chemical
6
Q
NTs AO3 +
A
SSRI drugs increase seretonin levels and reduce OCD symptoms
7
Q
NTs AO3 -
A
40% don’t respond to SSRI therapy
8
Q
Structure
A
Defective caudate nucleus means signals from orbito frontal cortex to thalamus aren’t blocked so sufferer is unable to switch off the impulse to perform behaviour