Explanations for OCD Flashcards

1
Q

Genetics

A

Tends to run in families
LEWIS - 37% pt w/ OCD have parents w/ OCD, 21% siblings

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2
Q

Twin studies

A

Nestadt et al
- meta analysis
- 68% MZ
- 32% DZ

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3
Q

Candidate genes

A
  • SERT gene- 5HT1-D beta gene transports seretonin across synaptic gap
  • COMT gene regulates the neurotransmitter dopamine
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4
Q

Genetic - AO3

A
  • likely to be polygenic = up to 230 genes involved
  • not 100% concordance - other factors
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5
Q

Neurotransmitters

A
  • low levels of seretonin leads to abnormal functioning of orbito frontol cortex and caudate nucleus (decision making)
  • high levels of dopamine leads to compulsive behaviours as dopamine is a rewarding chemical
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6
Q

NTs AO3 +

A

SSRI drugs increase seretonin levels and reduce OCD symptoms

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7
Q

NTs AO3 -

A

40% don’t respond to SSRI therapy

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8
Q

Structure

A

Defective caudate nucleus means signals from orbito frontal cortex to thalamus aren’t blocked so sufferer is unable to switch off the impulse to perform behaviour

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