Experiment #8: Carboxylic Acids And Derivatives Flashcards
TRUE OR FALSE:
Carboxylic Acids is soluble in organic solvent regardless of size
TRUE
TRUE OR FALSE:
Carboxylic Acid is soluble in water if it contains 7 or less than carbon atoms and has O atoms to hydrogen bond.
FALSE; it is soluble in water if it contains 5 or less than carbon atoms and has O atoms to hydrogen bond
It is a positive identification test for acids
Solubility in 6m NaOH
TRUE OR FALSE:
Carboxylic Acids is soluble if its ph level is less than 10
TRUE
TRUE OR FALSE:
A carboxylic acid that is insoluble in pure water will be soluble in base due to the formation of the sodium salt of the acid as the acid is neutralize by the base (HIGH MW)
TRUE
TRUE OR FALSE:
Carboxylic Acid is the strongest organic compound because of its resonance stability
TRUE
TRUE OR FALSE:
You can confirm if a compound is an acid if it reacts with a strong base
TRUE
The reaction of an alcohol with a carboxylic acid
Esterification
A cyclic ester is called a _____________
Lactone
What is the by product of Esterification?
H2O
What compounds we will need when performing Fischer’s Esterfication?
H+ and HCl
This is a test where alcohols react with carboxylic to form fruity smelling compounds called esters
Ester Test
In ester test, we used acids as catalyst such as _______?
H2SO4
TRUE OR FALSE:
By using a weak acid, an alcohol can react with a carboxylic acid (fischer esterification) to give an ester
FALSE; by using a strong acid
it involves loss of water (reverse of hydrolysis)
Dehydration
What is the chemical reaction of dehydration?
Condensation Reaction
It is the reaction with water where decomposition occurs more complex to decompose to simpler molecules
Hydrolysis
TRUE OR FALSE:
All acids derivatives yield carboxylic acids on hydrolysis
TRUE
TRUE OR FALSE:
Ester does not need acid/base catalyst (vigorous)
FALSE; it needs acid/base catalyst
TRUE OR FALSE:
Amide needs base catalyst and heating
TRUE
What is the positive result of Acid Hydrolysis?
Evolution of heat after addition of H2O, bubble (CO2) formation after addition of sodium bicarbonate (brisk effervesence)
Why do we put sodium bicarbonate when testing acid hydrolysis?
Because they react with carboxylic acids
IDENTIFICATION:
Alcohols react with ____ to form esters and carboxylic acids
Acetyl Anhydrides
TRUE OR FALSE:
In Hydrolysis of Acetyl Anhydride, the reaction is slower because acid anhydride aren’t so violently reactive as acyl chlorides.
TRUE
IDENTIFICATION:
These compounds are so reactive that they will react with water under neutral conditions.
Acid Halides and Anhydrides
What are the annoying side reaction of acid halides and anhydrides?
Air (moisture) sensitive
IDENTIFICATION:
In the Hydrolysis of Acid Halides and Anhydrides, hydrolysis can be avoided by using ___________ and ___________?
Dry Nitrogen Atmosphere & Anhydrous Solvents
What is the basic hydrolysis of esters called?
Saponification
What is the reverse reaction of the Fischer Esterification?
Acid Catalyzed Hydrolysis
TRUE OR FALSE:
In Hydrolysis of Esters, addition of excess water drives the equilibrium towards the side of the acid and alcohol
TRUE
They are the most reluctant derivatives to undergo hydrolysis, but they can be forced to by the use of vigorous conditions such as heating with 6M HCl or 40% NaOH for prolonged periods of time.
Amides
TRUE OR FALSE:
The carboxylic acid derivatives vary greatly in their reactivity with nucleophiles.
TRUE
What is the positive result for Base Hydrolysis?
Appearance of a blue color on the filter paper with ammonia or amine-like odor. After acidification, some compounds form precipitates or heterogeneous mixtures. Observation of characteristic odor of carboxylic acids.
TRUE OR FALSE:
In general, it is easy to convert more reactive derivatives into less reactive derivatives.
TRUE
In esterification, what is the carbonyl compound’s mechanism?
Nucleophilic Addition
