Exp 4 Flashcards
The common name for acetylsalisilic acid is
Aspirin
What are the uses of Aspirin
Analgesic
Anti-inflammatory
Antipyretic
Also platelet inhibitor or coagulant smth
What is the active constituent of aspirin
Salicin
Salicylic acid
Willow bark extracts
What is the usual amount of aspirin in a tablet
300-400 mg
What are the other ingredients in aspirin tablet
Caffeine and buffers
When ingested aspirin it is broken down to
Salicylic acid
What are some Precautions for Aspirin
- allergic reaction to ASA or other NSAIDS
- Kidney disease, liver diseases, diabetes
-Stomach problems
If taken with alcohol and tobacco aspirin can cause
Stomach bleeding
Aspirin is contraindicated with
Breast feeding women
Less than 18 years old
Pregnant woman
If you have these and if you experienced this you cannot take aspirin
Currently have aquired virus (chicken pox, flu)
If you recently received a vaccine
When used in children or used during or after viral infections aspirin can cause
Reyes’s syndrome
- liver damage
Some of the signs and symptoms of Reyes syndrome
Diarrhea
Vomiting
Rapid breathing
Seizure/convulsion
Salicylic acid contains what functiona group
Phenol group - which are known to be irritating
What company replaced phenol group of the salicylic acid to ester group?
Bayer company
What is the esterified compound of salicylic acid
Acetylsaliylic acid o Aspirin
Esterification causes a chemical reaction
that turns salicylic acid’ s hydroxyl group
into an acetyl group.
What is used to react salicylic acid
Excess of acetic anhydride
What is used as a catalyst in the synthesis of aspirin
Sulfuric acid
The aspirin isolated after separated is a
Crude drug
Why is acetic acid easily separated from the aspirin product
Because acetic acid is very soluble in water
If crude drug is recrystallized in hot ethanol it is now a
Purified product
To check the purity of the product what test is used
Ferric chloride test
What is the positive result of the ferric chloride test
Aspirin
Purple color solution
## footnote
Ferric chloride reacts with phenol to form an IRON PHENOL COMPLEX
Will commercial aspirin react with ferric chloride and produce a purple color?
NO
Commercial aspirin (aspirin in markets) lack presence of the phenol group which is need to form the IRON-PHENOL COMPLEX to give off purple color
What acan be used to create a purer aspirin
More acetic anhydride can be added
## footnote
Unredacted acetic anhydride can be removed by adding cold water
Salicylic acid is a /
Monoprotic acid
Uses of salicylic acid
Keratolytic agent - removal f dead skin cell
Treatment of fungal infection
Removal of warts and corns
Treatment for skin diseases
Salicin, the active constituent of salicylic acid is extracted from?
Willow bark extracts
Willow bark teas were used as?
Headaches remedies and other tonics
characteristic of salicylic acid
Odorless crystalline solid substance
Salicylic can cause marked irritation of
Gastric mucous membrane
What taste does salicylic have
Sweetish taste
What are some important preparations of salicylic acid
Sodium salicylate and
Methyl salicylate (oil f wintergreen)
Natural forms of salicylic acid
Salicin
Methyl salicylate
