Exercise oncology research

Question 1

What are the main findings of the ERASE trial? (Exercise during active surveillance in PCa)

Answer 1

A HIIT intervention:

• Less cancer anxiety (recurrence)
• Improved fitness (VO2)
• Reduced PSA biomarkers.
• Slowed in vitro growth of cancer cells.

Question 2

What are the main findings of the EXERT trial (Exercise during and after neoadjuvant rectal cancer treatment)?

Answer 2

Study group did HIIT walking/running 3 time per week during chemoradiation, and 150 min/week mod int during a break before surgery.
Exercise:
- Is safe and feasible
- May not improve fitness
may exacerbate symptoms and reduce QoL
- May not improve treatment toxicities or completion rates.
- May improve response to treatment!

Question 3

General findings for exercise during treatment

Answer 3

EX improves:
- physical fitness and function
- Body comp
- Some symptoms
- Some aspects of QoL
Preliminary evidence for
- Improved chemo completion rate and treatment response

Question 4

Main findings of the START trial (Supervised trials of aerobic versus resistance training in BC)

Answer 4

see slides

Question 5

Main findings of the HELP trial (healthy exercise for lymphoma patients)

Answer 5

Compared AET vs UC in lymphoma patients receiving chemo or off treatment with a main interest of QoL.
- Both groups improved VO2
- Improvements in QoL of both groups, which was greatest in the least healthy and the unmarried.
Reduced general fatigue

Question 6

Overall findings during survivorship

Answer 6

Similar outcomes to during treatment but with enhanced effects (QoL, fitness, some biomarkers). Preliminary evidence for improved cancer outcomes and overall survival.