EXERCISE 4

Question 1

AKA Aspirin

Answer 1

ACETYLSALICYLIC ACID

Question 2

It was used by Egyptians as topical poultice and is generally used for fever and
swelling.

Answer 2

Leaves from Willow tree

Question 3

The father of medicine, who prescribes
the leaves to be used as anti-pyretic, analgesic, and
used to relieve pain during childbirth.

Answer 3

Hippocrates

Question 4

A vicar in Norton, Oxfordshire who
submitted report that details the antipyretic effect of
dried, powdered willow bark.

Answer 4

Edward stone

Question 5

Salicylic acid is bitter and irritates the stomach. T/F

Answer 5

True

Question 6

In 1853, French chemistry ____________ defined the chemical structure of salicylic acid and synthesized acetylsalicylic acid using sodium salicylate
with acetyl chloride.

Answer 6

Charles Frederic Gerhardt

Question 7

German chemist who was researching for a nonirritating pain reliever to ease his father’s rheumatism. This was in 1897.

Answer 7

Felix Hoffman

Question 8

It is the oldest in a class of pharmaceuticals called
non-steroidal anti-inflammatory drugs (NSAIDs).

Answer 8

Aspirin

Question 9

The popularity of aspirin declined after the market
releases of paracetamol (acetaminophen) and ibuprofen T/F

Answer 9

True

Question 10

Years when paracetamol and ibuprofen where made

Answer 10

Paracetamol - 1956
Ibuprofen - 1969

Question 11

Synonyms of Aspirin

Answer 11

Acidum salicylicum
O-acetylsalicylic acid
Polypiryna
Salicylic acid acetate
2-acetoxybenzoic acid

Question 12

Salicylic acid, reacted with acetic
anhydride, with the introduction of?

Answer 12

ACETYL GROUP

Question 13

Salicylic acid is a type of Carboxylic acid with
may phenol. Salicylic acid, reacted with acetic
anhydride, with the introduction ACETYL GROUP. In
which the introduction of this group is called ___________

Answer 13

ACETYLATION.

Question 14

Characteristics of aspirin

Answer 14

Colorless/white crystalline
Odorless
Melts at 135 C

Question 15

Chemical test for aspirin

Answer 15

Acid Hydrolysis - Violet solution
Basic Hydrolysis - Clear solution

Question 16

When you subject aspirin for chemical test, following
acid hydrolysis using ___________ it should turn
purple.

Answer 16

Hydrochloric acid

Question 17

After the hydrolysis, aspirin produces

Answer 17

Salicylic acid
Acetic acid

Question 18

Upon addition of __________, the solution turns to violet because salicylic acid contains an enol, specifically, a _____.

Answer 18

Ferric Chloride
Phenol

Question 19

In basic hydrolysis, in the presence of _______ and upon addition to acetylsalicylic acid, it produces SODIUM _______ and _______ that will show a clear solution.

Answer 19

Sodium hydroxide
SODIUM ACETYLSALICYLATE
Water