Exchange and Transport Systems Flashcards

1
Q

What features increase the rate of movement of molecules across surfaces?

A

-large SA:V ratio
-very thin
-selectively permeable
-molecules can be moved away to keep the concentration gradient steep

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2
Q

Calculating SA:V

A

(surface area/volume):1

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3
Q

Describe and explain the relationship between an organism’s size and SA:V ratio.

A

The larger the organism the smaller the surface area to volume ratio, so the more heat they lose, the the higher the metabolic rate

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4
Q

Explain gas exchange in single-celled organisms

A

-Relatively large surface area, a thing surface and short diffusion distance (oxygen can take part in reactions as soon as it diffuses into the cell)- no need for specialised gas exchange system

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5
Q

Explain gas exchange in fish
(conc of oxygen in air<conc of oxygen in water)

A

-gills made of lots of thin plates called gill filaments giving a large SA for gas exchange therefore increased rate of diffusion
-gill filaments covered in lamellae (tiny structures) increasing the SA even more
-lamellae have lots of blood capillaries and a thin surface layer of cells to speed up diffusion between the water and the blood

counter-current system:
-blood flows through lamellae in one direction and water flows over them in the opposite direction
-means that water with a high oxygen concentration always flows next to blood with a lower oxygen concentration
-steep conc gradient maintained
-as much oxygen as possible diffuses from water into blood
-diffusion along length of lamellae

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6
Q

Explain gas exchange in dicotyledonous plants.

A

-mesophyll cells (in leaf) have a large SA
-gases move in and out through stomata
-guard cells control opening and closing of stomata and therefore water loss

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7
Q

Explain how the structure of plants helps them to limit water loss.

A

-hairs on epidermis trap water vapour round the stomata reducing the water potential gradient
-thick waxy cuticle reduces evaporation
-curled leaves protect stomata from wind that would otherwise increase the rate of diffusion and evaporation
-stomata in pits to trap water vapour reduce the water potential gradient
-reduced number of stomata- fewer places for water to escape

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8
Q

Explain gas exchange in insects.

A

-terrestrial insects have trachea (microscopic air-filled pipes) that branch off into smaller tracheoles which have thin permeable walls and go into individual cells
-air moves into trachea through pores on the surface called spiracles- oxygen diffuses directly into respiring cells
-air moves in and out of spiracles using rhythmic abdominal movements

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9
Q

How are insects adapted for efficient gas exchange?

A

-tracheoles have thin walls-short diffusion distance
-highly branched-short diffusion distance therefore large exchange surface area
-trachea provide tubes full of air- fast diffusion
-fluid in end of tracheoles that moves out during exercise- faster diffusion through air to gas exchange surface
-body can be moved by muscles to move air-maintains diffusion gradient for oxygen

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10
Q

What are the different ways respiratory gases can move in and out of the tracheal system in insects?

A

-along diffusion gradient- oxygen in, carbon dioxide out
-mass transport-muscle contraction squeezes trachea
-end of tracheoles filled with water- allow water and thus air to be drawn in due to a lowered water potential from lactate (product of anaerobic respiration)

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11
Q

Explain the advantage for larger animals having a specialised system that facilitates oxygen uptake.

A

-larger organisms have a smaller surface area to volume ratio
- specialised system overcomes long diffusion pathway
-faster diffusion

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12
Q

Describe the gross (not microscopic) structure of the human gas exchange system.

A

-the trachea have cartilage rings that strengthen it and prevent it from collapsing
-trachea divided into bronchi, bronchioles then alveoli

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13
Q

Describe what happens during inspiration.
ACTIVE

A

-The volume of our thoracic cavity increases and pressure decreases as the external intercostal muscles and diaphragm contract whilst the internal intercostal muscles relax

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14
Q

Describe what happens during expiration.
PASSIVE

A

-The volume of the thoracic cavity decreases and pressure increases as the internal intercostal muscles contract whilst the external intercostal muscles and diaphragm relax

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15
Q

Describe and explain how the lungs are adapted to allow rapid exchange of oxygen between air in the alveoli and blood in the capillaries around them.

A

-constant blood supply maintains concentration gradient so oxygen can rapidly diffuse into blood
-thin walls of blood capillaries create short diffusion distance
-flattened epithelium so short diffusion distance so fast diffusion
-ventilation maintains concentration gradient so fast diffusion
-many alveoli-large SA

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16
Q

Define digestion.

A

The hydrolysis of large insoluble molecules into smaller soluble molecules.

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17
Q

Describe starch digestion.

A

-amylase
-hydrolyses
-glycosidic bonds
-starch broken down into maltose
-maltase
-hydrolyses
-maltose to glucose

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18
Q

Explain how digestion of starch in the small intestine leads to an increase in the concentration of glucose in the blood.

A

-starch hydrolysed by amylase, then maltase
-produces glucose
-facilitated diffusion of glucose across the epithelium into the blood

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19
Q

Describe the processes involved in the absorption of the products of starch digestion.

A

-sodium ions removed from epithelial cell by active transport/sodium-potassium pump
-into blood
-maintaining low concentration of sodium ions in epithelial cell
-glucose moves in with sodium ions into epithelial cell
-via facilitated diffusion through a co-transport protein
-glucose moves into blood
-by (facilitated) diffusion

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20
Q

Describe protein digestion.

A

-endopeptidases hydrolyse the peptide bonds between the amino acids in the centre of the polypeptide
-increasing the SA, creating more ends for exopeptidases
-exopeptidases hydrolyse the peptide bonds between the terminal amino acids of the polypeptides
-this creates dipeptides and single amino acids
-membrane-bound dipeptidases hydrolyse the peptide bonds between the amino acids in these dipeptides

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21
Q

Describe lipid digestion.

A

-large fat droplets containing triglycerides
-triglycerides are emulsified by bile salts into small fat droplets making them more soluble
-small fat droplets
-lipase hydrolyses the ester bonds in triglycerides
-forming micelles (droplets of monoglycerides and fatty acids)

22
Q

Describe lipid absorption.

A

-micelles are absorbed into the epithelial cell (diffuse in as they are NON-POLAR)
-they are transported to the smooth ER where they are reformed into triglycerides
-triglycerides transported in vesicles to Golgi apparatus which modifies and processes them
-triglycerides associate with cholesterol and lipoproteins to form structures called chylomicrons
-chylomicrons are packaged into Golgi vesicles for release from the cell via exocytosis
-then absorbed into lacteals in the villi

23
Q

A student s concluded that the fish gas exchange
system is more efficient than the human gas exchange system.
Justify this conclusion

A

In fish, blood leaving has more oxygen than water leaving
(But) in humans, blood leaving has less oxygen than air leaving

24
Q

Describe and explain the mechanism that causes lungs to fill with air

A

Diaphragm contracts and external intercostal muscles
contract
Causes volume increase and pressure decrease
Air moves down a pressure gradient

25
Q

Describe the structure of haemoglobin

A

-quaternary structure made of 2- alpha and 2-beta polypeptide chains
-each chain is attached to a haem group so there are 4 haem groups
-each haem group has an iron ion and each iron ion combines with oxygen to form oxyhaemoglobin
- so 4 oxygen molecules can be carried by a single haemoglobin molecules in humans

26
Q

Explain why the binding of one molecule of oxygen makes it easier for a second oxygen molecule to bind

A

-binding of first oxygen changes the tertiary structure and therefore quaternary structure of haemoglobin
-uncovering another binding site
-positive cooperativity

27
Q

Describe the association and dissociation of oxygen

A

Association
Hb + oxygen -> oxyhaemoglobin
takes place in the lungs
Hb has a high affinity for oxygen so takes up more oxygen easily but releases less easily

Dissociation
Oxyhaemoglobin -> Hb + oxygen
takes place at respiring tissues
oxyhaemoglobin has a low affinity for oxygen so takes up oxygen less easily but releases more easily

28
Q

What must haemoglobin do to transport oxygen?

A

-readily bind (associate) with oxygen at the lungs
-readily release (dissociate) with oxygen at the respiring tissues

29
Q

How can haemoglobin associate and dissociate with oxygen?

A

-it can change its affinity for oxygen in different conditions
-by changing its shape in the presence of some substances e.g. carbon dioxide

30
Q

Describe partial pressure

A

-the pressure of a gas compared to the total pressure of a mixture of gases
-measured in kilopascals

31
Q

What does the oxygen dissociation curve show?

A

-the relationship between saturation of haemoglobin with oxygen and partial pressure of oxygen

32
Q

Explain the shape of the oxygen dissociation curve at the start. (low pO2 in respiring tissues)

A

-the gradient of the curve is shallow
-the first oxygen does not bind easily with the Hb due to closed united polypeptide chains
-therefore little oxygen binds to Hb

33
Q

Explain the shape of the oxygen dissociation curve in the middle. (medium pO2)

A

-the gradient is very steep
-binding of the first oxygen changes the tertiary and quaternary structure of haemoglobin, making it easier for the 2nd and 3rd oxygen to bind to the haem group- positive cooperativity
-a small increase in partial pressure of oxygen causes a big increase in oxygen saturation

34
Q

Explain the shape of the oxygen dissociation curve at the end. (high pO2 in the lungs)

A

-the curve plateaus
-after binding of 3rd oxygen, the majority of binding sites are occupied and the Hb is saturated
-therefore is it less likely that an oxygen will find a binding site- probability

35
Q

Explain how changes in the shape of haemoglobin result in the S-shaped (sigmoid) oxyhaemoglobin dissociation curve for HbA.

A

-1st oxygen binds to Hb causing change in shape
-allowing more oxygen to bind easily

36
Q

Explain the advantage to foetuses of oxygen dissociation curve being to left of that for its mother

A

-higher affinity for oxygen
-at low partial pressure for oxygen
-oxygen moves from mother to foetus

37
Q

Why are there many different oxygen dissociation curves?

A

-shape of haemoglobin can change under different conditions
-changing its affinity for oxygen

38
Q

Why does haemoglobin vary?

A

-different oxygen levels in habitat
-different metabolic rates- linked with SA:V

39
Q

Where is the oxygen dissociation curve
of small mammals in relation to that of humans and why?

A

-to the right
-affinity for oxygen is lower even at higher pO2
-oxygen more easily dissociated from Hb to tissues
-tissues can respire more and produce more heat

40
Q

Where is the oxygen dissociation curve
of large mammals in relation to that of humans and why?

A

-to the left
-higher affinity for oxygen even at lower pO2
-smaller SA:V ratio so less heat loss per unit body mass but greater rate of respiration due to total number of cells

41
Q

How does carbon dioxide affect the transport of oxygen by haemoglobin? ( the Bohr effect)

A

-the more active a tissue is, the more oxygen is unloaded
-higher rate of respiration-more carbon dioxide tissues produce-the lower the pH-the greater the haemoglobin shape change-the more readily oxygen is dissociated-the more oxygen is available for respiration
-Hb will only release 1 oxygen to resting tissues but ~3 to very active tissues

42
Q

What is the double circulatory system?

A

-blood passes through the heart twice
-PULMONARY CIRCUIT- between the heart and lungs
-SYSTEMATIC CIRCUIT-between the heart and other organs

43
Q

Describe the circulation of blood through the heart (starting with blood entering left side of heart)

A

-oxygenated blood from lungs enters the left atrium of the heart through the pulmonary vein
-the atrium contracts and the blood flows through the open atrio ventricular valve into the left ventricle
-blood leaves the left side of the heart by a huge contraction of the left ventricle forcing blood at high pressure through the semi-lunar valve and into the aorta to be pumped around the body
-in the body oxygen is used by tissues for respiration (Hb dissociates from oxygen)
-deoxygenated blood enters the right atrium of the heart through the vena cava
-when the right atrium is full contraction occurs forcing the blood through the atrio ventricular valve into the right ventricle, the valve closes
-when the right ventricle is full contraction occurs forcing the blood up through the semi-lunar valve and into the pulmonary artery to be pumped to the lungs
-in the lungs blood is oxygenated (Hb associates with oxygen) and carbon dioxide is removed

44
Q

What direction does blood flow in and how does this affect valve movement?

A

-Blood flows from high pressure to low pressure
-valves are always closed when pressure pf next chamber is greater than current one
e.g Atrioventricular valves close when blood is in ventricles because pressure in ventricles>pressure in atrium
-contractions increase pressure

45
Q

Describe the valves (3)

A

-atrioventricular valves between atria and ventricles, prevent back flow of blood into the atria
-semi-lunar valves in pulmonary artery and aorta, prevent back flow of blood in the ventricles
-pocket valves in the venal system preventing back flow of blood when veins are squeezed by muscles

46
Q

What is the vein and artery connecting 1. kidney to vena cava and 2. aorta to kidney

A

1.renal vein
2.renal artery

47
Q

What is the lymphatic system?

A

-drainage system
-drains fluid from tissues and deposits it in the vena cava

48
Q

What is tissue fluid?

A

-fluid that bathes tissue
-contains water, glucose, amino acids, oxygen
-allows exchange of materials into and out of cells

49
Q

Explain tissue fluid formation

A

-high hydrostatic pressure in arterioles due to contractions
-small molecules (glucose, oxygen, water) leave the capillaries, larger molecules remain
–called ultrafiltration
-hydrostatic pressure decreases in capillaries and water potential decreases as water has been filtered out

50
Q

Explain how tissue fluid returns

A

-water re-enters capillaries from high to low hydrostatic pressure via osmosis from high to low water potential
-water brings carbon dioxide and other waste products with it back into capillary
some fluid enters lymph vessels to form lymph
-vessels form the lymphatic system which connects the blood system nearer the heart at the vena cava via the thoracic duct