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Intro to Biochem & Mol Bio > Exam Three > Flashcards

Exam Three Flashcards

1
Q

hexokinase replaced by

A

G6Pase

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2
Q

PFK replaced with

A

FBPase

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3
Q

gluconeogenesis

A

fructose biphosphate and G6Pase (must be tightly controlled) happens in LIVER

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4
Q

free G6Pase

A

would deplete all ATP in the cell making tight 2 enzyme cycle w/ hexokinase

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5
Q

cori cycle ATP cost in liver

A

6

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6
Q

cori cycle ATP cost in muscle

A

2

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7
Q

CAC is ___ compared to glycolysis

A

strongly oxidative (connected to glycolysis via pyruvate DH complex)

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8
Q

CAC takes place in

A

matrix (vs. glycolysis in cytoplasm)

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9
Q

products of CAC

A

NADH and FADH2 (fee electrons into oxidative phosphorylation yielding ATP)

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10
Q

E3

A

Pyruvate DH Complex

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11
Q

succ DH

A

inner membrane/membrane bound

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12
Q

irreversible steps

A

citrate synthase, pyr DH complex, isocitrate DH, alpha KGDH complex

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13
Q

electron transport directly produces

A

protein gradient (drive ATP synthesis)

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14
Q

malate aspartate shuttle

A

heart liver kidney

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15
Q

ATP/ADP translocase

A

ATP out to cytoplasm ADP come in (antiport)

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16
Q

coupling

A

at rest rate of O2 goes down bc ATP is high

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17
Q

uncoupling

A

abnormal state can be induced by various things(UCPI, 2,4 DNP) symptoms: hot, rapid breathing, feel weak, burning tops of fuel but not making ATP bc ATP synthesis is uncoupled from O2 use

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18
Q

complex I inhibitor

A

retenone, amytal

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19
Q

complex III inhibitor

A

antimycin A

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20
Q

complex IV inhibitor

A

cyanide, azide, carbon monoxide

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21
Q

PPP makes

A

NADPH and ribose

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22
Q

30 carbon rxn

A

want sugar but no NADPH: non ox branch

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23
Q

fixed ratio of 2 NADPH for every Ribose 5P

A

oxidative branch

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24
Q

only NADPH and no ribose 5P

A

part of oxidative and non ox (resembles CAC)

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25
Q

glutathione

A

“redox” buffer to protect cells against oxidation

26
Q

Wenicke Korsakoff syndrome

A

lack of thiamine can’t saturate enzymes mut in transketolase

27
Q

Calvin cycle

A

rxn from gluceoneo and PPP

28
Q

“hitting the wall”

A

depleting glycogen (need 8 pieces of bread, big piece of cake, or banana split)

29
Q

“a” form of glycogen phosphorylase

A

added phosphates, normally “on”, LIVER

30
Q

“b” form of glycogen phosphorylase

A

no phosphates, “off” (can be turned on allosterically by AMP low E charge) MUSCLE (turned on during exercise)

31
Q

F-2,6-BP signals

A

plenty of glucose

32
Q

pyruvate carboxylase works perfectly in absence of

33
Q

pyruvate DH complex - FAD is attached to

34
Q

2 enzymes with FeS cluster

A

succinate DH, aconitase

35
Q

not inhibited by ATP and NADH

36
Q

C3 of pyruvate labelled one turn of CAC

37
Q

isocitrate lyase is important in

A

glyoxylate cycle

38
Q

cyto c is located in

A

intermemb space

39
Q

pamaquine induced hemolytic anemia

A

G6PDH deficiency, RBC membrane cross links get brittle

40
Q

calvin cycle

A

PPP + gluconeogenesis

41
Q

transkeltolase

A

covalent attachment of substrate to thiamine phosphate

42
Q

F1

A

contains catalytic sites for ATP synth, contains alpha beta gamma subunits, mostly matrix

43
Q

F0

A

proton channel, spans inter mito membrane, contains a b c subunits

44
Q

TPP at active site

45
Q

C1 labelled 1 turn of CAC

A

none lost as CO2

46
Q

substrate level phosphorylation in CAC catalyzed by

A

succinyl CoA synthase

47
Q

ubiquinone

A

linked btwn electron transport and proton pumping moving H+ across mito membrane

48
Q

“sugar can make you fat but not sweet” not true for

A

glyoxalate cycle

49
Q

glycerol phosphate shuttle

A

glycerol phosphate + DHAP

50
Q

C2 labelled after 1 turn of CAC

A

C4 is labelled

51
Q

succ DH does not catalyze

A

oxidative decarboxylation

52
Q

gamme subunit of Racker’s Knob

53
Q

ox of 1 mole of Acetyl CoA produces

54
Q

cofactor of transketolase

55
Q

ketone bodies do NOT include

A

alpha KG and OAA

56
Q

anaplerotic rxns in mammals

A

convert pyruvate in OAA

57
Q

cori cycle

A

responsible for lactate and glucose in blood

58
Q

ATP formed when electrons from FADH2 are transported to O2 via MET

59
Q

transaldolase rxn

A

Sedo7P + G3P = E4P + F6P

60
Q

transketolase

A

Eryth4P + Xylulose 5P = Fru6P + Gly3P

Intro to Biochem & Mol Bio (2 decks)

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