Exam IV: HIV Drugs (Protease Inh.)

Question 1

Atazanavir

Answer 1

3-Letter: ATV
Class: Protease Inhibitor
Brands: Reyataz, Evotaz
Dose/Frequency: 
300mg + 100mg RTV 
OR
400mg (if RTV not tolerated)

Question 2

Atazanavir

Answer 2

3-Letter: ATV
Class: Protease Inhibitor
Dose/Frequency: 
300mg + 100mg RTV 
OR
400mg (if RTV not tolerated)

Question 3

a

Answer 3

3-Letter:
Class:
Dose/Frequency

Question 4

a

Answer 4

Common:
Serious:

Question 5

ATV

Answer 5

Azatanavir
Common: N/V, rash, increased serum cholesterol, fever, cough, serum bilirubin, jaundice
Serious: Breathing conduction problems, hepatic/renal impairment

Question 6

Darunavir

Answer 6

3-Letter:
Class: Protease Inhibitor
Dose/Frequency:

Question 7

a

Answer 7

Common:
Serious:

Question 8

a

Answer 8

3-Letter:
Class: Protease Inhibitor
Dose/Frequency:

Question 9

a

Answer 9

Common:
Serious:

Question 10

a

Answer 10

3-Letter:
Class: Protease Inhibitor
Dose/Frequency:

Question 11

a

Answer 11

Common:
Serious:

Question 12

ATV

Answer 12

Azatanavir
Common: N/V, rash, increased serum cholesterol, fever, cough, serum bilirubin, jaundice
Serious: Breathing conduction problems, hepatic/renal impairment

Question 13

Darunavir

Answer 13

3-Letter: DRV
Class: Protease Inhibitor
Brands: Prezista, Prezcobix
Dose/Frequency: 
800mg + RTV 100mg QD (NAIVE OR RAMS)
600mg + RTV 100mg BID (EXPERIENCED)

**Prezcobix: 1 TAB QD

Question 14

DRV

Answer 14

Darunavir
Common: N/V, diarrhea
Serious: Severe rash, hepatoxicity

Question 15

Fosamprenavir

Answer 15

3-Letter: FPV
Class: Protease Inhibitor
Brands: Lexiva
Dose/Frequency: 
1400mg + 100-200mg RTV QD (NAIVE)
700mg + 100mg RTV BID (EXPERIENCED)

Question 16

FPV

Answer 16

Fosamprenavir
Common: N/V, diarrhea, headache
Serious: Hemolytic anemia

Question 17

Indinavir

Answer 17

3-Letter: IDV
Class: Protease Inhibitor
Brands: Crixivan
Dose/Frequency: 
800mg q8h (UNBOOSTED)
800mg + 100mg RTV (BOOSTED

Question 18

IDV

Answer 18

Indinavir
Common: GI issues, headache, rash, dizziness, alpecia
Serious: Thrombocytopenia, hemolytic anemia

Question 19

Lopinavir

Answer 19

3-Letter: LPV/r
Class: Protease Inhibitor
Brands: Kaletra
Dose/Frequency: 
2 TAB BID
4 TAB QD

Question 20

LPV/r

Answer 20

Lopinavir
Common: N/V, diarrhea, abdominal pain
Serious: QTc prolongation, altered cardiac conduction

Question 21

Lopinavir

Answer 21

3-Letter: LPV/r
Class: Protease Inhibitor
Brands: Kaletra
Dose/Frequency: 
2 TAB BID
4 TAB QD

Question 22

LPV/r

Answer 22

Lopinavir
Common: N/V, diarrhea, abdominal pain
Serious: QTc prolongation, altered cardiac conduction

Question 23

Nelfinavir

Answer 23

3-Letter: NFV
Class: Protease Inhibitor
Brands: Viracept
Dose/Frequency: 
1250mg BID
750mg TID

Question 24

NFV

Answer 24

Nelfinavir
Common: N/V, abdominal pain, rash, elevated LFTs
Serious: Hepatic impariment

Question 25

Ritonavir

Answer 25

3-Letter: RTV
Class: Protease Inhibitor
Brands: Norvir
Dose/Frequency: 
300mg BID then 600mg BID

Question 26

RTV

Answer 26

Ritonavir
Common: N/V, diarrhea, dyspepsia, abdominal pain, fatigue, dizziness, rash, cough
Serious: Edema, peripheral neuropathy

Question 27

Saquinavir

Answer 27

3-Letter: SQV
Class: Protease Inhibitor
Brands: Invirase
Dose/Frequency:
1000mg + 100mg RTV BID

Question 28

SQV

Answer 28

Saquinavir
Common: N/V, rash, fatigue
Serious: QTc prolongation risk

Question 29

Tipranavir

Answer 29

3-Letter: TPV
Class: Protease Inhibitor
Brands: Aptivus
Dose/Frequency:
500mg + 200mg RTV BID

Question 30

TPV

Answer 30

Tipranavir
Common: N/V, diarrhea, rash,
Serious: hepatotoxicity, intracranial hemorrhage