Exam IV: HIV Drugs (NRTIs)

Question 1

Abacavir (Brand/Class/Dose/Freq)

Answer 1

3-Letter: ABC
Class: NRTI (Nucleoside Reverse Transcriptase Inhibitor)
Brands: Ziagen, Epzicom, Trizivir, Triumeq
Dose/Freq: 300mg BID or 600mg QD

Question 2

ABC (ADEs)

Answer 2

Abacavir
Common: N/V, diarrhea, fever, headache, rash
Serious: 
  BLACK BOX
  -sometimes fatal hypersensitivity rxn

Question 3

Didanosine

Answer 3

3-Letter: DDL
Class: NRTI (Nucleoside Reverse Transcriptase Inhibitor)
Brands: Videx, Videx EC
Dose/Freq: 
 250mg QD
>60kg --> 400mg QD

Question 4

DDL

Answer 4

Didanosine
Common: N/V, diarrhea, peripheral neuropathy, increased LFTs
Serious: Lactic acidosis, hepatomegaly
  BLACK BOX
  -pancreatitis

Question 5

Emtricitabine

Answer 5

3-Letter: FTC
Class: NRTI (Nucleoside Reverse Transcriptase Inhibitor)
Brands:Emtriva, Truvada, Aripla, Complera, Stribild
Dose/Freq:
CAP 200mg QD
SOLN 240mg QD

Question 6

FTC

Answer 6

Emtricitabine
Common: N/V, diarrhea, headache, rash, skin discoloration
Serious: Lactic acidosis, hepatic changes, insulin resistance

Question 7

Lamivudine

Answer 7

3-Letter: 3TC
Class: NRTI (Nucleoside Reverse Transcriptase Inhibitor)
Brands: Epivir, Combivir, Epzicom, Trizivir, Triumeq
Dose/Freq: 150mg BID, 300mg QD

Question 8

3TC

Answer 8

Lamivudine
Common: N/V, diarrhea, rash, fatigue, dizziness, neutropenia
Serious: Lactic acidosis, anemia, pancreatitis

Question 9

Stavudine

Answer 9

3-Letter: D4T
Class: NRTI (Nucleoside Reverse Transcriptase Inhibitor)
Brands: Zerit
Dose/Freq:
 30mg q12h
>60kg --> 40mg q12h

Question 10

D4T

Answer 10

Stavudine
Common: N/V, diarrhea, abdominal pain, rash, headache, peripheral neuropathy, increased LFTs
Serious: Mitochondrial toxicity, lactic acidosis, hepatomegaly, pancreatitis, neuromuscular weakness

Question 11

x

Answer 11

3-Letter:
Class: NRTI (Nucleoside Reverse Transcriptase Inhibitor)
Brands:
Dose/Freq:

Question 12

x

Answer 12

Common:
Serious:

Question 13

Tenofovir

Answer 13

3-Letter:
Class: NRTI (Nucleoside Reverse Transcriptase Inhibitor)
Brands: Viread, Truvada, Atripla, Complera, Stribild
Dose/Freq: 300mg QD

Question 14

TDF

Answer 14

Tenovofir
Common: GI upset, bloating, renal insufficiency, osteomalacia, decreased bone density, increased LFTs
Serious: Lactic acidosis, pancreatitis, bone tox.

Question 15

Zidovudine

Answer 15

3-Letter: AZT, ZDV
Class: NRTI (Nucleoside Reverse Transcriptase Inhibitor)
Brands: Retrovir, Combivir, Trizivir
Dose/Freq: 300mg BID

Question 16

AZT, ZDV

Answer 16

Zidovudine
Common: N/V, headahce, insomnia, anorexia, malaise
Serious: Macrocytic anemia, hepatotoxicity, cardiomyopathy, respiratory failure