Exam II Drugs Flashcards
Vesamicol
Blocks ACh-H+ antiporter
Inhibits ACh storage in vesicles
Hemicolinium
Inhibits choline transport into neuron
Botulinum Toxin
Degrades SNAP-25 protein of SNAP complex (blocks ACh release)
Neostigmine
Longer-acting AChE competitive inhibitor (prolongs action of ACh)
Edophonium
Short-acting AChE competitive inhibitor (Used to adjust medication dosage and for diagnosing Myasthenia Gravis)
Pyridostigmine
Longer-acting AChE competitive inhibitor (prolongs action of ACh)
Ambenonium
Longer-acting AChE competitive inhibitor (prolongs action of ACh)
Physostigmine
Non-polar inhibitor of AChE (non-polar so can cross BBB and is useful for CNS anticholinergic toxicity)
Diisopropyl flurophosphate
Organophosphate (irreversible inhibitor of AChE)
Tacrine
AChE inhibitor with symptomatic benefits in Alzheimer’s disease
Donepezil
AChE inhibitor with symptomatic benefits in Alzheimer’s disease
Galantamine
AChE inhibitor with symptomatic benefits in Alzheimer’s disease. Also is non-potentiating ligand of nicotinic receptors.
Rivastigmine
AChE inhibitor with symptomatic benefits in Alzheimer’s disease. (Also affects both AChE and BChE)
Methacholine
Muscarinic receptor agonists
Carbachol
Muscarinic receptor agonist (higher Nicotinic action than other choline esters)
Bethanechol
Muscarinic receptor agonist (almost completely selective for muscarinic receptors)