Exam II Drugs Flashcards

0
Q

Vesamicol

A

Blocks ACh-H+ antiporter

Inhibits ACh storage in vesicles

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1
Q

Hemicolinium

A

Inhibits choline transport into neuron

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2
Q

Botulinum Toxin

A

Degrades SNAP-25 protein of SNAP complex (blocks ACh release)

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3
Q

Neostigmine

A

Longer-acting AChE competitive inhibitor (prolongs action of ACh)

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4
Q

Edophonium

A

Short-acting AChE competitive inhibitor (Used to adjust medication dosage and for diagnosing Myasthenia Gravis)

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5
Q

Pyridostigmine

A

Longer-acting AChE competitive inhibitor (prolongs action of ACh)

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6
Q

Ambenonium

A

Longer-acting AChE competitive inhibitor (prolongs action of ACh)

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7
Q

Physostigmine

A

Non-polar inhibitor of AChE (non-polar so can cross BBB and is useful for CNS anticholinergic toxicity)

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8
Q

Diisopropyl flurophosphate

A

Organophosphate (irreversible inhibitor of AChE)

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9
Q

Tacrine

A

AChE inhibitor with symptomatic benefits in Alzheimer’s disease

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10
Q

Donepezil

A

AChE inhibitor with symptomatic benefits in Alzheimer’s disease

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11
Q

Galantamine

A

AChE inhibitor with symptomatic benefits in Alzheimer’s disease. Also is non-potentiating ligand of nicotinic receptors.

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12
Q

Rivastigmine

A

AChE inhibitor with symptomatic benefits in Alzheimer’s disease. (Also affects both AChE and BChE)

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13
Q

Methacholine

A

Muscarinic receptor agonists

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14
Q

Carbachol

A

Muscarinic receptor agonist (higher Nicotinic action than other choline esters)

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15
Q

Bethanechol

A

Muscarinic receptor agonist (almost completely selective for muscarinic receptors)

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16
Q

Cevimeline

A

Muscarinic receptor agonist (M1, M3 agonist; used to treat xerostomia)

17
Q

Philocarpine

A

Muscarinic receptor agonist (M1, M3 agonist; used to treat xerostomia)

18
Q

Succinylcholine

A

Nicotinic receptor agonist (Short duration; used for paralysis during intubation “depolarizing cascade”)

20
Q

Atropine

A

Muscarinic receptor antagonists (marginal Nicotinic activity)

21
Q

Scopolamine

A

Muscarinic receptor antagonist (Significant CNS effects; used for Motion Sickness)

22
Q

Pirenzepine

A

Muscarinic receptor antagonist

23
Q

Methscopolamine

A

Muscarinic receptor antagonist (delayed but measurable CNS antichol effects)

24
Q

Glycopyrrolate

A

Muscarinic receptor antagonist (delayed but measurable CNS antichol effects)

25
Q

Ipratropium

A

Muscarinic receptor antagonist (More effective than Beta adrenergic agonist in treating COPD)

26
Q

Tiotropium

A

Muscarinic receptor antagonist (similar, possibly superior, efficacy as a bronchodilator in treating COPD)

27
Q

Oxybutynin

A

Non-specific Muscarinic receptor antagonist (used for overactive bladder)

28
Q

Propantheline

A

Non-specific Muscarinic receptor antagonist (used for overactive bladder)

29
Q

Terodiline

A

Non-specific Muscarinic receptor antagonist (used for overactive bladder)

30
Q

Tolterodine

A

Non-specific Muscarinic receptor antagonist (used for overactive bladder)

31
Q

Trospium

A

Non-specific Muscarinic receptor antagonist (used for overactive bladder)

32
Q

Darifenacin

A

Selective M3 receptor antagonist (used for overactive bladder)

33
Q

Solifenacin

A

Selective M3 receptor antagonist (used for overactive bladder)

34
Q

Pancuronium

A

Nicotinic receptor antagonist (long-acting; used for neuromuscular blockade during surgery)

35
Q

Tubocuraine

A

Nicotinic receptor antagonist (long-acting; used for neuromuscular blockade during surgery)

36
Q

Vecuronium

A

Nicotinic receptor antagonist (intermediate-acting; used for neuromuscular blockade during surgery)

37
Q

Rocuronium

A

Nicotinic receptor antagonist (intermediate-acting; used for neuromuscular blockade during surgery)

38
Q

Mivacurium

A

Nicotinic receptor antagonist (short-acting; used for neuromuscular blockade during surgery)

39
Q

Trimethaphan

A

Nicotinic receptor antagonist (Used for hypertension in patients with acute aortic dissection)

40
Q

Mecamylamine

A

Nicotinic receptor antagonist (Used for hypertension in patients with acute aortic dissection)