Exam I Flashcards

1
Q

Schedule I Controlled Substances

A

high potential for abuse

heroine

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2
Q

Schedule II Controlled Substances

A

high potential for abuse
physical and psychological dependency
oxycodone, hydrocodone, hydromorphone

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3
Q

Schedule III Controlled Substances

A

some potential for abuse
limited psychological and physical dependency
up to 5 renewals in 6 months
testosterone

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4
Q

Schedule IV Controlled Substances

A

low potential for abuse
limited psychological and physical dependency
alprazolam, phentermine, tramadol

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5
Q

Schedule V Controlled Substances

A

subject to state/local regulation
may be sold Rx or OTC in some states
pregabalin

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6
Q

Pregnancy Category A

A

no risk to fetus in first trimester

no evidence of risk in later trimesters

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7
Q

Pregnancy Category B

A

no risk to fetus in animal studies, but no well-controlled studies in pregnant women

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8
Q

Pregnancy Category C

A

adverse effects on fetus in animal studies, but no well-controlled studies in pregnant women
benefits may outweigh risks

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9
Q

Pregnancy Category D

A

positive human fetal risk has been reported

considering potential benefit versus risks may, in some select cases, warrant the use of these drugs in pregnant women

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10
Q

Pregnancy Category X

A

fetal abnormalities were reported, and positive evidence of fetal risk in humans is available from animal or human studies
risks clearly outweigh the benefits
drugs should not be used in pregnant women

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11
Q

Recommendations for Writing Prescriptions

A

legible; verbal orders should be minimized
include purpose when appropriate
use metric system except for therapies that use standard units, in which case write out units
oral doses should be expressed with metric weight or volume and always include concentration or mg dose when using mL
include patient age and weight when appropriate
include drug name, exact metric weight or concentration, and dosage form
a leading zero should always be used before a decimal and a terminal zero should never be used after a decimal
avoid abbreviations

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12
Q

Report Medication Errors to:

A

FDA: MedWatch
Institute for Safe Medication Practices (ISMP)
Medication Errors Reporting (MER) Program/ US Pharmacopeia
US/MEDMARX (anonymous)

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13
Q

Pharmacodynamics

A

what drugs do to the body
mechanism of action
biochemical/physiologic effects

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14
Q

Pharmacokinetics

A

what the body does to the drugs

absorption, distribution, metabolism, excretion, half life

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15
Q

Pharmacology

A

the study of pharmacodynamics and pharmacokinetics

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16
Q

Drug

A

any substance that is used for diagnosis, cure, treatment, or prevention of disease/condition

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17
Q

Drug Receptors

A

bind to a drug molecule (with high affinity) and send (transduce) a signal/do something
not all drug receptors do something
what happens depends on the drug molecule

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18
Q

Affinity

A

strength of the binding between a drug and its receptor

what gets the drug bound to the receptor

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19
Q

Efficacy

A

ability of a drug to initiate max biological effect/stimulate receptor to produce pharmacological response
dictates what happens to the drug

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20
Q

Potency

A

measure of the ability of a set dose of an agonist or antagonist to produce its maximum pharmacological effect
used to compare drugs
ex. 10 mg Drug A = 5 mg Drug B

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21
Q

Quantity

A

amount of drug that reaches the receptor

may lose drug to first pass metabolism, can’t reach drug receptor site, etc.

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22
Q

Agonist

A

resembles naturally occurring hormone, neurotransmitter, or enzyme
bind and activate the receptor
act longer than the natural substances that they mimic

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23
Q

What are the two types of Agonists?

A

Full Agonist - acts with max effect

Partial Agonist - acts with less than max effect

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24
Q

Antagonist

A

bind to receptor and block the action of an endogenous agonist

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25
What are the two types of Antagonist?
Competitive: competes with agonist and can be overcome by increasing concentrations of agonist Noncompetitive: irreversibly bound
26
Binding Mechanisms for Receptors
ionic bonding Van der Waals bonding Hydrogen bonding
27
Selectivity
preference of a drug for certain receptor sites | non-selective drugs cause more side effects
28
How do drugs act on drug receptors?
direct activation of ion channel G-protein activation of ion channel G-protein activation of second messenger system Receptor activation of intracellular enzyme (tyrosine kinase) transcription factors act on enzymes
29
Effective Dose 50 (ED50)
50% of people respond
30
Lethal Dose 50 (LD50)
50% of people die
31
Toxic Dose 50 (TD50)
50% of people (animals) show toxicity
32
Therapeutic Index (TI)
a window of dosage in which a drug is effective, but not toxic TD50/ED50 the larger the TI, the safer the drug; the higher the dose to be toxic over the smaller dose to be effective if best lower TI means a risky drug
33
Five Basic Parameters of Pharmacokinetics
``` absorption distribution metabolism excretion half-life ```
34
Most drugs pass cell membranes by....?
passive transport
35
Absorption
when a drug is taken from the site of administration to the bloodstream determined by: the drug's properties (pH, lipid solubility/insolubility, ionized/unionized, molecular weight), drug formulation, route of administration must be in a solution (ex. tablets must dissolve) must cross cell membranes to reach the bloodstream (except IV)
36
Drugs cross cell membranes easier if they are...?
lipid soluble and unionized (like cell membranes!)
37
Bioavailability
the extent and rate that a drug enters systemic circulation
38
What affects Bioavailability?
largely determined by the properties of dosage form and the site of administration drugs can be digested in first-pass metabolism, may be poorly absorbed in the GI tract, and/or may not be completely absorbed
39
First-Pass Metabolism
when drugs are digested before reaching the blood stream mainly a function of the liver
40
Generic Drugs
drugs that replace brand name drugs on the market must prove that they have the same bioavailability as the brand-name drug; the same amount of drug has to reach the bloodstream at the same rate
41
Oral Route of Administration
tablets, liquid, chewable tablets usually the most convenient, easiest, and least expensive route most commonly used route of administration about 30 min - 2 hr onset
42
In order to be absorbed, Oral Routes must....
survive pH, GI secretions, and enzymes have enough time to be absorbed/be absorbed quickly (food slows gastric secretion and may affect absorption) have adequate blood flow to the intestines
43
What is Enteric Coating, and why is it important?
Enteric coating can be added to oral routes of administration. Some drugs can harm the lining of the stomach and cause irritation. Enteric coating can help prevent drugs from dissolving in the stomach, but still allows for dissolution in the small intestine.
44
Subcutaneous Injection Route
can be formulated to prolong absorption (internal depot) can be irritating 30 min onset
45
Intramuscular Injection Route
for injecting larger volumes than subcutaneous (short term depot) more blood flow than subcutaneous can be irritating 5 min onset
46
Intravenous Injection Route
30 sec onset of peak plasma drug levels - fast! precise administration sell controlled short duration in the body good for irritating solutions (inject into larger veins) or water soluble solutions more difficult to administer, uncomfortable, and once it is administered, you cannot get it back
47
Intrathecal Injection Route
inserted into spinal theca rapid/local effects to CSF rapid side effects
48
Sublingual and Buccal Route
absorbed under the tongue or between the gums and cheek; not swallowed rapid absorption, but may be incomplete or erratic ex. Nitroglycerin for the heart
49
Rectal Route
suppositories, solutions, creams, ointments, and foams in general, any drug that can be given orally, can be given rectally, so rectal administration is useful when eating is difficult or impossible absorption is faster that in oral routes and can be local or systemic, but absorption can also be unpredictable and erratic affected by first pass metabolism
50
Vaginal Route
suppositories, solutions, creams, ointments, foams, and tablets absorption can be local or systemic, but can also be variable long-term absorption is possible (IUD) less drug degradation than oral
51
Ocular Route
liquids (may run off quickly) and gels (remains in the eyes better than liquid, but may blur vision) local absorption; if it is absorbed systemically, it may cause side effects
52
Otic Route
solutions or suspensions local absorption
53
Nasal Route
atomized (small droplets) drug is rapidly absorbed through the nasal mucous membrane systemic or local effects
54
Inhalation Route
absorbed in the lungs, so these are rarely used, except for lung medications or gasses for general anesthesia atomized/aerosolized (smaller than nasal routes) ex. inhaleres 1 min onset or less
55
Nebulization Route
aerosolized requires nebulizer easier for young children or those who struggle with inhalers 1 min onset
56
Cutaneous Route
ointment, cream, lotion, solution, powder, or gel typically used for local effect, but can have systemic absorption
57
Transdermal Route
patch can be used for long periods of time and provide continuous dosing of drugs (external depot), but are only useful for potent, lipophilic drugs can cause skin irritation slower than subcutaneous route (>> 30 min onset)
58
Distrubution
when drug moves from the bloodstream to the tissues depends on: - blood perfusion - more blood, more drug to tissues (ex. inramuscular administration) - tissue mass (fat stores drugs, so more body fat leads to more drug storage) - ability to permeate capillaries and move from blood to tissue - amount of free/unbound drug in the blood stream - tissue binding (volume of distribution) - accumulation (storage in body) - blood brain barrier
59
Volume of Distribution
theoretical volume necessary to contain total amount of administered drug at the same concentration that is observed in the plasma; theoretical volume of fluid in which a drug administered would have to be diluted to produce the same concentration of drug observed in plasma high for drugs that primarily bind to tissues low for drugs that primarily remain in the bloodstream = total amount of drug in the body/concentration in the plasma
60
Accumulation of Drugs in the Body
accumulation of drugs stored in body components (tissues and bone) can prolong drug action; it is released as plasma concentrations are used up
61
Blood Brain Barrier
made up of endothelium of brain capillaries and the astrocytic sheath tight junctions between endothelial cells slow diffusion of water-soluble drugs lipid-soluble drugs can enter the brain, but polar compounds, protein-bound drugs, and ionized drugs cannot some unintended drugs pass the blood brain barrier and cause side-effects (sedation)
62
Relationship of Metabolism Rate and Drug Concentration
metabolism rate has an upper limit based on the number of occupied enzyme sites most enzyme sites are not occupied, so metabolism increases with drug concentration
63
Pro-Drug
drugs that are weakly active or inactive, but have active metabolites; need to be metabolized to work
64
Excretion
removal of drugs and metabolites primarily carried out by the kidneys through urine, but also in bile/feces, saliva, sweat, tears, breast milk, lungs
65
Renal Clearance
total amount of drug excreted by over time through kidneys; rate that drugs are excreted form the kidneys
66
Kidney Excretion
Glomerular Filtration - filtration moves drugs from blood to urine; protein-bound drugs and other high molecular weight drugs are not filtered (take longer to be excreted); glomerular filtration rate measures how well the kidneys are filtering Tubular Reabsorption - most water and electrolytes are reabsorbed into circulation, along with lipid-soluble drugs Tubular Excretion - polar and ionized compounds (most drugs and metabolites) are not reabsorbed and are instead excreted in urine unless there are active transport systems in place to assist them
67
How does urine pH affect drug reabsorption?
increases reabsorption and decreases excretion of weak acids, decreases reabsorption and increases excretion of weak bases
68
Half-Life
measure of how long it will take for half of a drug to be eliminated from the bloodstream helps determine dosing intervals, time it takes to reach 'steady state,' and when a drug is cleared Does not determine absorption of drug! 5-6 half-lives to eliminate a drug from the body rate of drug release from tissues affects half-life; some drugs remain bound in tissues longer than others
69
Onset of Routes of Administration: Fastest (30 sec - 1 min)
IV inhalation
70
Onset of Routes of Administration: Fast (5 min)
intramuscular
71
Onset of Routes of Administration: Mid (30 min)
subcutaneous oral
72
Onset of Routes of Administration: Slow (2 hours +)
transdermal oral
73
Duration that drugs act on the body depend on:
half life, body clearance, and the drug can be extended by depot (internal, external)
74
CYP450
enzyme involved with metabolism that is found in all tissues of the body; metabolize many drugs variable depending on genetics, race/ethnicity, and age can be induced or inhibited by drugs
75
Drug Interactions and Metabolism
can prevent or increase the action of a drug can make toxic effects more likely can slow or speed up excretion of a drug can increase or decrease metabolism of a drug
76
Hepatic Impairment
liver failure, impairment, disease, etc. can impact how drugs are metabolized, and may affect efficacy and excretion drug dose adjustment may be necessary
77
Loading Dose
an initial high dose of drug given at the beginning of a course of treatment to reach and remain above the minimum effective drug concentration in the body; following doses are lower to maintain steady state
78
Where are most otic drugs administered?
the external auditory ear canal, but some are for the middle ear
79
What is the correct way to administer ear drops?
wash hands adults - gently pull ear up and back children - gently pull ear down and back keep ear facing up for several minutes after administering drops use cotton plug in the ear to maintain medicine within the canal
80
Are eardrops absorbed in the skin?
Not typically; only absorbed through the skin if the skin is broken
81
Otitis Externa
infection of the outer ear pain on movement of the pinna etiology: history of swimming or exposure to contaminated water typically caused by gram-negative rods or fungi rarely life-threatening get culture, if it is still present after one week of treatment
82
How is Otitis Externa generally treated?
Otic Anti-Infectives with or without corticosteroids | Acid-Alcohol Solutions
83
Bacteriostatic
antibiotic or anti-infective that prevents the growth of bacteria
84
Bacteriocidal
kill bacteria
85
What is the usual administration route of Otic Anti-infectives?
topical; not usually absorbed through the skin
86
Why are steroids sometimes combined with otic anti-infectives?
corticosteroids are used for their anti-inflammatory, antipruritic, and anti-allergenic effects; reduce inflammation, relieve symptoms, and the reduction in inflammation may help the topical meds reach more of the ear anti-infectives with corticosteroids are more commonly prescribed than those without
87
What risks should you be aware of when prescribing otic anti-infectives?
risk of ototoxicity, especially formulations containing neomycin do not prescribe if you believe the patient might have ruptured ear drums or tubes in their ears
88
What would you prescribe for serious cases of Otitis Externa? (if cellulitis is present)
fluoroquinolones: ciprofloxacin or ofloxacin kill pseudomonas
89
What are the most commonly prescribed medications for Otitis Externa?
ciprofloxacin/hydrocortisone | ciprofloxacin/dexamethasone
90
Adverse Reactions of Otic Anti-Infectives
similar for with or without steroids ear pain ear discomfort or irritability ear residue ototoxicity - neomycin, tubes, perforated eardrum contact dermatitis - itchy rash (Neomycin)
91
Otic Anti-infectives Contraindications
hypersensitivity to active ingredients or vehicle (other stuff in the medication that holds the drug) Neomycin - tubes or perforated eardrums
92
Acid-Alcohol Solutions
supplement natural defense mechanism of the ear (naturally acidic environment) induce drying of cellular infective agents (bacteria cannot survive) provide topical, antibacterial, and antifungal effect used for superficial infections of the external auditory canal
93
Adverse Effects of Acid-Alcohol Solutions
stinging and burning local irritation do not use with perforated eardrums or ear tubes Anti-infectives with steroids are more commonly prescribed
94
How do you treat water-clogged ears?
95% isopropyl alcohol and 5% anhydrous glycerin (swimmer's ear, Auro Dri drops, FDA approved) 50:50 acetic acid (5%) and isopropyl alcohol (95%) (recommended by American Academy of Otolaryngology)
95
Otitis Media
middle ear infection common in children 1/2 of cases are bacterial (S. pneumonia, Haemophilus influenza, Moraxella catarrhalis, Streptococcus pyrogenes) 1/2 of cases are viral be cautious when prescribing antibiotics - they will not work for viral infections, but will cause side-effects
96
How is Acute Otitis Media pain treated?
pain should be assessed and treated with acetaminophen and/or ibuprofen
97
In what cases would you prescribe antibiotics for Acute Otitis Media?
6 mo+ with bilateral or unilateral Acute Otitis Media and severe signs and symptoms 6-23 mo with bilateral Acute Otitis Media
98
In what cases would you watch and wait and consider proscribing antibiotics for Acute Otitis Media?
6 mo-23 mo with non-severe unilateral Acute Otitis Media 24 mo+ with nonsevere Acute Otitis Media
99
What antibiotics are used to treat Acute Otitis Media?
Amoxicillin is the drug of choice Amoxicillin/Clavulanate provides B-lactase coverage that is necessary if Amoxicillin was recently used or the patient had previous Amoxicillin resistance Oflaxacin can be a good choice if the patient has tubed ears
100
Cerumenolytics
cerumen softening agents aimed at softening and removing ear wax from the external auditory canal water based, oil based, nonwater/nonoil based
101
Adverse Effects of Cerumenolytics
``` mild itching burning ear pain erythema of the ear canal allergic reactions (emergency) ```
102
Contraindications of Cerumenolytics
perforated ear drum or ear tubes ear discharge, pain, rash, or irritation around the ear
103
How to Use Cerumen-Softening Agents?
instill in ear once wax is softened, follow with warm water irrigation using otic syringe ensure drops are removed completely with irrigation (leaving drops in longer than 30 minutes causes irritation) don't use q-tips to clean out wax
104
How to Administer Eyedrops
wash hands before and after administration remove contacts unless using contact-safe formulations look up, pull lower lid down, and instill drops close eye to allow medication to have max effect (can occlude tear duct with finger - punctual occlusion) don't touch dropper tip wait 5+ minutes between different eye drop meds and use ointments after drops
105
Two Classes of Ophthalmic Anesthetics
amino esters: tetracaine and proparacarpine | amino amide: lidocaine
106
Clinical Use of Ophthalmic Anesthetics
to produce local anesthesia for ophthalmic procedures, removing foreign bodies or sutures, scraping for diagnosis
107
Improper use of Ophthalmic Anesthetics can cause...?
deep corneal infiltrates, ulceration, and perforation only to use on occasion; do not prescribe
108
Ophthalmic Anesthetics Mode of Action
penetrate to sensory nerve endings in the corneal tissue where they bind to receptors within the sodium channels and block the movement of sodium, inhibiting depolarization along the axon and preventing the pain stimulus from reaching the spinal cord
109
Ophthalmic Anesthetics Pharmacokinetics
work within 20-30 seconds and last up to 15 minutes (may need to be re-dosed) A: rapid at corneal capillaries; local action D: protein binding is high (protein-bound remain in bloodstream) M: unknown in the eye/skin; some may be metabolized if it's systemically absorbed E: unknown for lidocaine, but tetracaine and proparacaine through bile T 1/2: proparacaine is shortest, lidocaine is intermediate, and tetracaine is longest
110
Ophthalmic Anesthetics Adverse Reactions
burning and stinging upon application if used over days: severe keratitis, opacification, scarring of the cornea and loss of vision possible (rare)
111
Conjunctivitis
inflammation of the conjunctiva caused by allergens, bacteria, viruses, and fungi (rare)
112
Ophthlamic Anti-Infectives Adverse Reactions
local irritation blurry vision super infections possible with long-term use/ resistance hypersensitivity to sulfacetamide is possible (sulfa allergy is a contraindication) little to no systemic absorption
113
Allergic Conjunctivitis Symptoms and Etiology
``` Symptoms: chronic and recurring itching slightly red eyes tearing and blurring little discharge ``` ``` Etiology: animal hair pollen ragweed plants ```
114
Ophthalmic Mast Cell Stabilizers
inhibit degranulation of mast cells after exposure to antigen - reduces histamine release used for allergic conjunctivitis and keratitis no significant systemic absorption used less often than antihistamines
115
Ophthalmic Mast Cell Stabilizers Adverse Effects
``` transient stinging and burning blurry vision photophobia mydriasis rhinitis sinusitis headache ```
116
Ophthalmic Antihistamines
block the effects of histamines released during allergic reactions and blunt its symptoms H1 blockers - bind and block H1 receptors, preventing a normal signal from sending (antagonists) temporarily relieve itching associated with allergic conjunctivitis little to no systemic absorption
117
Which Ophthalmic Antihistamines are prescribed more often?
ketotifen and olopatadine
118
Ophthalmic Antihistamine Adverse Effects
``` transient stinging and burning blurry vision photophobia Mydriasis Rhinitis Headache ```
119
Ophthalmic Vasoconstrictors/Decongestants
weak sympathomimetic (raise blood pressure and constrict blood vessels in the conjunctiva) used to temporarily relieve eye redness not for dry eyes not usually recommended because of adverse reactions
120
Ophthalmic Vasoconstrictors/Decongestants Adverse Reactions
Avoid if: heart disease, high blood pressure, enlarged prostate, narrow-angle glaucoma, or are a contact wearer contraindication: narrow-angle glaucoma - these drugs cause mydriasis which could worsen glaucoma and result in permanent eye damage systemic adverse effects: tachycardia and aggravation of arrythmias local adverse effects: burning, stinging, and blurry vision interactions: increase pressor effects if used with MAOIs and tricyclics
121
Dry Eye
caused by tear film instability due to deficiency of any tear film component ``` Presentation: ocular discomfort desire to rub eyes blurred vision burning reness ```
122
Ophthalmic Lubricants
contain agents that provide hydration, maintain moisture, and protect the eye Used: - to supplement natural tears, when relief of dry eyes is needed or to wash away irritants - as viscosity enhancers that promote increased contact time of an ophthalmic agent with the ocular surface - for secondary corneal edema recommended preservative free if used frequently
123
Artificial Tears
act as demulcents (protective film) to mimic mucin (glyocprotein of mucus
124
Ocular Emollients
protects and prevents drying
125
Ocular Ointments
have longer contact more likely to cause blurred vision often prescribed to take at bedtime
126
Corneal Edema
``` Symptoms: foggy vision halos around lights photophobia irritation sensation of a foreign body extreme pain ``` caused by prolonged contact lens wearing, infection, gluacoma, or iritis treated with Sodium Chloride (2-5%)
127
Pupillary Dilation Agents
used to dilate pupils (mydriasis) - inhibition of circular muscle MOA: muscarinic agents - block parasympathetic receptors that would normally cause pupils to constrict if stimulated
128
Pupillary Dilation Agents Averse Reactions
``` tachycardia flushing of cheeks blurry vision photophobia dry mouth slurred speech, drowsiness, hallucinations congestion irritated eyes ``` contraindications: closed angle glaucoma - dilation can occlude outflow of aqueous humor, increasing intraoccular pressure, further impeding outflow
129
Mydriatic
dilates pupils
130
Miotic
constricts pupils
131
Gluacoma
increased intraocular pressure (IOP) - causes pathologic changes in optic nerve and visual field defects Pathogenesis: changes in aqueous humor outlfow that result in increased intraocular pressure - leads to optic nerve atrophy and loss of vision Intraocular pressure increases due to decreased elimination of aqueous humor or increased production of aqueous humor
132
Angle-Closure Glaucoma (Closed-Angle)
aqueous humor cannot leave the anterior chamber shallow anterior chamber leads to a narrow angle, so iris dilation can block the angle and comprise aqueous humor filtration pupillary blockage of aqueous humor outflow; as aqueous humor increases in the anterior chamber, the lens if pushed further, and blocks the angle further EMERGENCY can be triggered by many drugs (pupillary dilators and vasoconstrictors)
133
Open-Angle Glaucoma
the canal of Schlemm is blocked angle of the anterior chamber remains open, but filtration of aqueous humor is gradually diminished because of the tissues of the angle 80-90% of glaucoma cases decreased elimination of aqueous humor as it passes through trabecular meshwork
134
Glaucoma Treatment Principles
reduce IOP to prevent optic nerve damage and visual field loss use topical medications as first-line treatment acute angle-closure glaucoma is an emergency
135
Prostaglandin Analogues
Treat Glaucoma 1st line treatment increase outflow of intraocular aqueous humor through uveoscleral pathway -prost
136
B Antagonists/ Beta Blockers
Treat Glaucoma blockade of sympathetic nerve endings in ciliary epithelium, decreasing aqueous humor formation and lowing intraocular pressure B-blockers bind to receptors in the ciliary body and prevent some aqueous humor formation -olol
137
Adrenergic Agonists
Treat Glaucoma decreases aqueous humor production, maybe increases outflow vasoconstriction leads to decrease in production bind to alpha 2 receptors in the ciliary body and cause vasoconstriction
138
Carbonic Anhydrase Inhibitors
Treat Glaucoma decrease volume of aqueous humor by slowing action of carbonic anhydrase (enzyme) carbonic anhydrase is involved in formation of aqueous humor
139
Cholinergics
Treat Glaucoma cause parasympathetic response, which causes miosis direct - directly stimulate ocular cholinergic receptors (act like acetylcholine) indirect - bind to and inactivate cholinesterases (break down acetylcholine) --> keep acetylcholine around
140
Cholinergics Mechanism of Action
contracts the iris sphincter muscle, resulting in miosis ciliary muscles attach to the trabecular meshwork; contraction opens the canal of Schlemm, increasing the outflow of aqueous humor, and decreases IOP
141
Glaucoma treatments that slows down production of aqueous humor
beta blockers, alpha 2 agonists, carbonic anhydrase inhibitors
142
Glaucoma treatments that increase outflow of aqueous humor
prostaglandins and cholinergics/muscarinics
143
Allergic Rhinitis
exposure to allergens causes nasal symptoms allergen binds B-cell - B-cell triggers plasma cell - plasma cell releases antibodies - mast cells find antibodies bound to allergens - mast cells degranulate to histamine and other chemicals (cytokines) - histamine and other chemicals cause smooth muscle contraction, mucus secretion, vascular permeability, sensory nerve stimulation Presentation: Nasal - congestion, rhinorrhea, nasal pruritis, sneezing, post-nasal drip Ocular - itching, lacrimation, redness, irritation General - headache, malaise, mood swings, irritability
144
Allergic Rhinitis Nonpharmacologic Treatment
avoid allergens
145
Allergic Rhinitis Pharmacologic Treatment
mild - 2nd generation, non-sedating antihistmines prn moderate - combinations of intranasal steroids, antihistamines, and decongestants for nasal symptoms, and ophthalmic antihistamine for ocular symptoms severe - refer to specialty/immunology
146
Intranasal Corticosteroids
reduce ocular symptoms, nasopharyngeal itching, sneezing, and rhinorrhea decrease influx of inflammatory cells, inhibit release of cytokines, which reduce inflammation of mucosa onset is less than 30 minutes need to be taken for 2-4 weeks for max efficacy more effective than antihistamines in persistent and more severe cases
147
Antihistamines
reduce nasopharyngeal itching, sneezing, and rhinorrhea H1 receptor antagonists; block histamine receptor 1st generation - cause sedation, non-selective 2nd generation - selective, low incidence of sedation onset: 15-30 minutes immediate, temporary relief for once in awhile usage
148
Antihistamine Pharmacokinetics
``` A: rapid D: 60-70% protein bound M: minimal; desloratadine is a prodrug E: fexofenadine, desloratadine, and loratadine through feces and urine; all others through urine T 1/2: variable ```
149
Oral Decongestants
reduce rhinorrhea alpha-adrenergic agonists - vasoconstriction; constriction of blood vessels decrease blood supply to the nasal mucosa, decreasing nasal edema no effect on histamine 15-30 minute onset just helps with symptoms
150
Oral Decongestant Side Effects
headache elevated blood pressure - bad for glaucoma tremor urinary retention dizziness tachycardia insomnia - ask for shorter acting and don't take at HS Contraindications: hypertension, heart disease, diabetes, hyperthyroidism, enlarged prostate, narrow-angle glaucoma, blood pressure
151
Topical Decongestant
reduces rhinorrhea alpha agonists act locally as vasoconstrictors; constriction of blood vessels decreases blood supply to nose, which decrease mucosal edema no effect on histamine ``` Side Effects: minimal systemic absorption (good option for patients with other conditions) local burning nasal irritation and dryness sneezing ``` REBOUND CONGESTION - don't use for mroe than 3-5 days
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Immunotherapy
subcutaneous injections of allergen 5-7 years; can last up to 12 can be very effective ``` reserved for patients: unresponsive to usual treatment who cannot tolerate usual treatment who want to avoid long-term med use with allergic asthma ```
153
Common Cold
usually viral results in release of numerous inflammatory mediators - cytokines ``` Presentation: sore throat nasal symptoms watery eyes sneezing cough malaise low-grade fever ``` gradual onset, slow progression 1-2 weeks
154
Nonpharmacologic Cold Treatments
humidifiers, increase fluid intake, rest
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Pharmacologic Cold Treatments
Decongestants - nasal congestion Analgesics - pain, headache Local Anesthetic - lozenges, sprays
156
Treat Fever
acetominophen | NSAIDS (non-steroidal anti-inflammatory drugs): ibuprofen and naproxen
157
Who should you avoid prescribing cough medicine to?
children under 6 yo
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What might be effective alternative treatments for cough?
``` high-dose inhaled corticosteroids buckwheat honey nasal irrigation with saline vapor rub zinc sulfate ```
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Cough Treatments
Antitussives Expectorant Sore Throat Remedies
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Sore Throat/ Cough Remedies
saline gargle sprays, lozenges (benzocaine, dyclonine, phenol, menthol) honey lots of water
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Innate Immunity
natural immunity
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Two Types of Acquired Immunity
Humoral - antibodies and B cells | Cellular - no antiboidies and T cells
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Gell and Coombs Hypersensitivity Classification Types
Type I: IgE-mediated (anaphylaxis/allergy) Type II: Cytotoxic Reaction - antibodies attack drug coated cells Type III: Immune Complex - drug-antibody deposits on tissues; 1-3 weeks after exposure Type IV: Delayed, Cell-mediated; drug rash; 2-7 days after exposure
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Type I Hypersensitivity
IgE-mediated Mild - allergic rhinitis Moderate - Urticaria (Hives) and Andioedema (Swelling) Severe - Anaphylaxis
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Biphasic Reaction
a second reaction of Anaphylaxis that can occur hours later