Exam 5 - Renal

Question 1

Acetazolamide (DIAMOX)

Answer 1

Class: Diuretic - carbonic anhydrase inhibitor
MOA: Block carbonic anhydrase
Effects: 
Indications: Not used for diuresis anymore
-Reduce intraocular pressure (glaucoma)
-Epilepsy -Motion sickness
SE: Metabolic acidosis
*Oral

Question 2

Mannitol

OSMITROL

Answer 2

Class: osmotic diuretic 
MOA: Increases urine volume by increasing tubular fluid osmolarity.
Effects: 
Indications: Cerebral edema
-Acute decrease of intraocular pressure
-Oliguria/anuria due to trauma or shock
-Acute kidney injury
CI: Pulmonary edema/heart failure, progressive renal disease, metabolic edema.
*No oral/IV

Question 3

Furosemide (LASIX)

Answer 3

Class: Loop diuretic
MOA: Inhibit Na+ K+ 2Cl- symport in thick ascending limb of loop of Henle
Effects:
Indications: HTN, edema, hypercalcemia, ARF
SE: hypo K, Ca, Mg, Na, ototoxic, sulfa
*IV/Oral

Question 4

Bumetanide (BUMEX)

Answer 4

Class: Loop diuretic
MOA: Inhibit Na+ K+ 2Cl- symport in thick ascending limb of loop of Henle
Effects:
Indications: HTN, edema, hypercalcemia, ARF
SE:
*IV/Oral

Question 5

Torsemide (DEMADEX)

Answer 5

Class: Loop diuretic
MOA: Inhibit Na+ K+ 2Cl- symport in thick ascending limb of loop of Henle
Effects:
Indications: HTN, edema, hypercalcemia, ARF
SE:
Oral/IV

Question 6

Ethacrynic Acid (EDECRIN)

Answer 6

Class: Loop diuretic
MOA: Inhibit Na+ K+ 2Cl- symport in thick ascending limb of loop of Henle
Effects:
Indications: HTN, edema, hypercalcemia, ARF, sulfa allergies, gout
SE:
Oral/IV

Question 7

Hydrochlorothiazide

HYDRODIURIL, MICROZIDE

Answer 7

Class: 
MOA: 
Effects: 
Indications: 
SE: 
*Oral

Question 8

Chlorthalidone (HYGROTON)

Answer 8

Class: 
MOA: 
Effects: 
Indications: 
SE: 
*Oral

Question 9

Indapamide (LOZOL)

Answer 9

Class: 
MOA: 
Effects: 
Indications: 
SE: 
*Oral

Question 10

Metolazone (ZAROXOLYN)

Answer 10

Class: 
MOA: 
Effects: 
Indications: 
SE: 
*Oral

Question 11

Triamterene (DYRENIUM, MAXZIDE)

Answer 11

Class: 
MOA: 
Effects: 
Indications: 
SE: 
*Oral

Question 12

Amiloride

MIDAMOR

Answer 12

Class: 
MOA: 
Effects: 
Indications: 
SE: 
*Oral

Question 13

Spironolactone (ALDACTONE)

Answer 13

Class: 
MOA: 
Effects: 
Indications: 
SE: 
*Oral

Question 14

Eplerenone (INSPRA)

Answer 14

Class: 
MOA: 
Effects: 
Indications: 
SE: 
*Oral

Question 15

Nesiritide

NATRECOR

Answer 15

Class: 
MOA: 
Effects: 
Indications: 
SE: 
*IV

Question 16

Desmopressin

DDAVP, STIMATE

Answer 16

Class: 
MOA: 
Effects: 
Indications: 
SE: 
*IV, intranasal, oral, sublingual

Question 17

Tolvaptan (SAMSCA)

Answer 17

Class: 
MOA: 
Effects: 
Indications: 
SE: 
*Oral

Question 18

Conivaptan (VAPRISOL)

Answer 18

Class: 
MOA: 
Effects: 
Indications: 
SE: 
*IV

Question 19

Captopril (CAPOTEN)

Answer 19

Class: 
MOA: 
Effects: 
Indications: 
SE: 
*Oral

Question 20

Enalapril (VASOTEC)

Answer 20

Class: 
MOA: 
Effects: 
Indications: 
SE: 
*Oral

Question 21

Lisinopril

PRINIVIL, ZESTRIL

Answer 21

Class: 
MOA: 
Effects: 
Indications: 
SE: 
*Oral

Question 22

Irbesartan (AVAPRO)

Answer 22

Class: Angiotensin Receptor Antagonists (ARBs)
MOA: block AT1 receptor, and most effects of AT2
Effects:
Indications:
SE:
CI: teratogenic
*Oral

Question 23

Losartan (COZAAR)

Answer 23

Class: Angiotensin Receptor Antagonists (ARBs)
MOA: 
Effects: 
Indications: 
SE: 
CI: teratogenic
*Oral

Question 24

Aliskiren (TEKTURNA)

Answer 24

Class: Direct Renin Inhibitor
MOA: renin inhibitor, blocks Angiotensin I so cannot be converted to Angiotensin II.
Effects:
Indications: HTN, end organ damage
SE: well tolerated, GI, HA, angioedema, cough
CI: prego
*Oral