Exam 5 Antilipemics

Question 1

Which drugs are inhibitors of cholesterol synthesis? (HMG-CoA reductase inhibitors, “Statins”)

Answer 1

Simvastatin (Zocor)

Atorvastatin (Lipitor) Lovastatin (Mevacor)

Question 2

Which drug is an inhibitor of VLDL synthesis and secretion?

Answer 2

Niacin (Nicotinic Acid, Vitamin B3) (Niacor)

Question 3

Which drugs are bile acid-binding resins?

Answer 3

Cholestyramine (Questra) Colestipol (Colestid)

Question 4

Which drug is an inhibitor of cholesterol absorption?

Answer 4

Ezetimibe (Zetia)

Question 5

Which drugs are fabric acid derivatives (fibrates)

Answer 5

Fenofibrate (Tricor) Gemfibrozil (Lopid)

Question 6

Statins - Lipitor, Zocor, Mevacor

Answer 6

Class: Inhibitors of Cholesterol Synthesis MOA: inhibits HMG-CoA Reductase
Use: 1st line for hypercholesterolemia
SE: m protein degradation, renal burden/failure
Contra: prego, breast feeding, kids <10

Question 7

Niacin (Nicotinic Acid, Vitamin B3) (Niacor)

Answer 7

Class: Inhibitors of VLDL synthesis and secretion
MOA:
-Reduces lipolysis in adipose, synthesis of VLDL and TRGs in the liver
-Inhibits VALD secretion
-Increases production of apolipoprotein A-1 Uses: vLDL/^HDL
SE: flushing, liver toxic, hyperuricemia (gout)

Question 8

Cholestyramine (Questran) Colestipol (Colestid)

Answer 8

Class: Bile Acid-Binding Resins
Use: Hypercholesterolemia, Pruritus (dt cholestasis/liver failure)
SE: constipation, flatulence, reduced absorption of fat soluble vitamins (A,D,E,K)
*safe in peds/liver dz

Question 9

Ezetimibe (Zetia)

Answer 9

Class: Inhibitors of Cholesterol Absorption
Use: vLDL
SE: Myalgias, Transaminitis (in the liver)

Question 10

Fenofibrate (Tricor) Gemfibrozil (Lopid)

Answer 10

Class: fibrates
MOA: ^expression of lipase = breaks down lipase
Uses: high triglycerides 
SE: myalgia, myopathy, GI
Contra: liver/biliary dz
*safe in peds