EXAM 5 - Journal Article

Question 1

Explain the objective of the journal article.

Answer 1

Investigate the effect of rifampin on the PK and PD of gliclazide, a sulfonylurea antidiabetic drug.

Question 1

Explain the objective of the journal article.

Answer 1

Investigate the effect of rifampin on the PK and PD of gliclazide, a sulfonylurea antidiabetic drug.

Question 2

Explain the method of the experiment.

Answer 2

• ranodmized 2-way crossover study w/ a 4-week washout period
• 9 korean subjects were treated once daily for 6 days with 600 mg rifampin or with placebo
• on day 7, single dose of 80 mg oral gliclazide
• meaured concentration of plasma glicazide, blood glucose, and insulin

Question 3

What were the results of the experiment?

Answer 3

• rifampin decreased the mean area under the curve (plasma concentration-time curve) by 70%
• also decreased the mean elimination half-life from 9.5 to 3.3 hours
• oral clearance of gliclazide increased about 4-fold after rifampin treatment
• significant difference in the blood glucose response to gliclazide was observed between the placebo and rifampin phases