Exam 5 - B-vitamin questions

Question 1

Hyperlipidemia could decrease with which supplement due to the increased rate of beta-oxidation and commitment of acetyl-CoA to Krebs cycle instead of cholesterol biosynthesis?

Answer 1

Pantothenate

Question 2

Which vitamin is essential for producing neurotransmitters, heme, amino acids, nucleic acids, and glucose?

Answer 2

Pyridoxine

Question 3

Which B vitamin causes toxicity, and what is the primary clinical observation of toxicity?

Answer 3

Pyridoxine, peripheral neuropathy

Question 4

Beri Beri can present as “wet” beri beri is associated with cariovascular disease dysfunction, while “dry” beri beri is associated with neuropathy. In wet beri beri, clinical presentation is caused by impaired erythrocyte function, and so the enzyme __________ is not functioning without thiamine, while in dry beri beri, the presentation of neuropathy is primarily associated with the lack of _____ enzyme activity without thiamine.

Answer 4

Transketolase; alpha-ketoglutarate dehydrogenase

Question 5

Which vitamin is important in stimulating glucokinase in pancreatic cells, and also required for carboxylase reactions?

Answer 5

Biotin

Question 6

Trina is a 50 year old woman who smokes 40 cigarettes and drinks half a bottle of gin (equivalent to 10 drinks) each day. Trina restricts her food intake for weight control, and has a BMI of 17. She presents with blistering on her ankles and dorsal region of her feet, and a rash on her hands, forearms, and periorbital skin. Trina has cyclic diarrhea and constipation. Prednisone cephalexin treatment did not reduce her blisters or rash. However, after 1 week of 50 mg twice daily treatment with _____ the symptoms improved.

Answer 6

Nicotinamide

Question 7

Which enzyme reaction does NOT require FAD or FADH2?

Answer 7

NADH dehydrogenase

Question 8

Ester is a 75 year old widow who has failing health since the death of her husband 7 years ago. All symptoms except photophobia and fissures on her tongue and corners of he mouth resolved. Which vitamin supplement should she also have?

Answer 8

Riboflavin

Question 9

Which sulfur containing molecule will support Krebs cycle?

Answer 9

Alpha-lipoic acid

Question 10

Which vitamin would be required to convert trytophan to nicotinamide?

Answer 10

Pyridoxal phosphate