Exam 5 Flashcards
mechlorethamine, melphalan, ifosfamide, cyclophosphamide, chlorambucil - class
nitrogen mustards - DNA damaging agents
carmustine, streptozoxin - class
nitrosoureas - DNA damaging agents
oxaliplatin, carboplatin, cisplatin - class
platinum coordination complexes - DNA damaging agents
mechlorethamine, melphalan, ifosfamide, cyclophosphamide, chlorambucil, carmustine, streptozoxin, oxaliplatin, carboplatin, cisplatin - Target
causes intra/interstrand cross links
mechlorethamine, melphalan, ifosfamide, cyclophosphamide, chlorambucil, carmustine, streptozoxin, oxaliplatin, carboplatin, cisplatin - biochemical/physiological responses
inability of cell to separate DNA, initiation of DNA repair mechanisms
cell can’t replicate DNA or make proteins - cell undergoes apoptosis if can’t repair in time
mechlorethamine, melphalan, ifosfamide, cyclophosphamide, chlorambucil, carmustine, streptozoxin, oxaliplatin, carboplatin, cisplatin - adverse effects
hematological (myelosuppression), hepatotoxicity, nephrotoxicity, neurotoxicity, nausea, dehydration, malnutrition
mechlorethamine, melphalan, ifosfamide, cyclophosphamide, chlorambucil, carmustine, streptozoxin, oxaliplatin, carboplatin, cisplatin - interactions
TNF blockers, clozapine, deferiprone, leflunomide, zidovudine, thalidomide, nephrotoxic agents
temozolomide, decarbazine - class
triazenes- DNA damaging agents
temozolomide, decarbazine - target
addition of methyl group to DNA bases (guanine)
temozolomide, decarbazine - biochemical/physiological
incorrect DNA base matching during replication
loss of DNA fidelity - leads to mutation and loss of protein function
temozolomide, decarbazine - adverse effects
hematological (myelosuppression), immunosuppression, hepatotoxicity, nausea, dehydration, malnutrition
temozolomide, decarbazine - interactions
TNF blockers, clozapine, deferiprone, leflunomide, zidovudine, thalidomide, nephrotoxic agents
daunorubicin, doxorubicin, idarubicin - class
anthracycline antibiotics - DNA damaging agents
daunorubicin, doxorubicin, idarubicin - target
intercalates into DNA and inhibits topoisomerase 2
daunorubicin, doxorubicin, idarubicin - biochemical/physiological
inability to replicate DNA or make proteins, initiates DNA repair mechanisms
halt of DNA cell cycle progression, loss of cellular function - cell undergoes apoptosis if can’t repair DNA in time
daunorubicin, doxorubicin, idarubicin - adverse effects
hematological, cardiovascular, nausea, dehydration, malnutrition
daunorubicin, doxorubicin, idarubicin - interactions
clozapine, deferiprone, TNF blockers, leflunomide, thalidomide, prolongs QT interval
bleomycin, mitomycin - class
anthracenedione antibiotics - DNA damaging agents
bleomycin, mitomycin - target
intercalates into DNA causing DNA crosslinks and double/single strand breaks
bleomycin, mitomycin - biochemical, physiological
inability to replicate DNA or make proteins, initiates DNA repair mechanisms
halt of DNA cell cycle progression, loss of cellular function - cell undergoes apoptosis if can’t repair in time
bleomycin, mitomycin - adverse effects
hematological, nausea, dehydration, malnutrition, nephrotoxicity, lung fibrosis
bleomycin, mitomycin - interactions
clozapine, deferiprone, TNF blockers, leflunomide, thalidomide
methotrexate - class
DNA replication - antimetabolite
methotrexate - target
competitive inhibitor of dihydrofolate reductase