Exam 4 - Heart Failure -organized Flashcards
Stages of Heart Failure
Stage A:
Stage B:
Stage C
Stage D:
Stage A: At risk (risk factors but no structural changes or symptoms)
Stage B: Pre- heart failure (structural changes but no symptoms)
Stage C: Heart failure (symptoms like shortenss of breath and fatigue)
Stage D: Advanced heart failure (symptoms don’t respond to treatment)
S1
Heart Failure is defined as a complex syndrome that results from:
any structural or functional impairment of ventricular filling or blood ejection
2
Five signs of tissue-hypoperfusion that result from HF:
fatigue, dyspnea, weakness, edema, and weight gain
2
HF may be caused by structural abnormalities of what 5 cardiac structures?
pericardium, myocardium, endocardium, heart valves, or great vessels
2
what EF % classifies HF with reduced EF (aka systolic HF)?
EF ≤ 40%
2
what EF % classifies HF with preserved EF (aka diastolic HF)?
EF ≥50%
2
A pt with clinical symptoms with an EF between ___ - ___% is labeled as having borderline HF w/ preserved EF
40-50%
2
True or false: Diastolic dysfunction is present in both HFrEF and HFpEF.
True!
2
Patters of what 2 things are the major distinguishing features between HFrEF and HFpEF?
LV dilation and remodeling
2
What serves as the main marker for establishment of HF risk factors, treatment, and outcome?
Ejection Fraction!
2
Which of the 2 HFs are women more likely to be affected by?
HF w preserved EF
Diastolic HF
3
Which of the 2 HFs are men more likely to be affected by?
HF with reduced EF
Systolic HF
3
Which HF is more likely to have modifiable risk factors and a higher prevalence of MI, previous coronary intervention, CABG, and PVD?
HF w reduced EF
3
what is the primary determinant of HFpEF?
left ventricular diastolic dysfunction
4
what 5 things determine LV’s ability to fill?
pulmonary venous blood flow
LA function
mitral valve dynamics
pericardial restraint
active and passive elastic properties of LV
4
What 3 things are majority of measurements of LV Diastolic dysfxn dependent on?
HR, loading conditions, and myocardial contractility
4
Higher ________ are required to achieve normal end-diastole volume in pts with HFpEF.
LV filling pressures
4
What is the steeper rise of the end-diastolic pressure-volume curve indicative of?
what does it result in regarding LV compliance?
delayed LV relaxation and an increase in myocardial stiffness
resulting in reduced LV compliance that restricts filling
5
The reduced LV compliance that eventually restricts filling can precipitate what (regarding the left atrium and pulm system)?
LA hypertension, LA systolic & diastolic dysfunction,
pulmonary venous congestion, and exercise intolerance
5
What does the left picture indicate about contractility?
what does the right picture indicate regarding LV compliance?
Left: a decrease in myocardial contractility as indicated by a decrease in the slope of the end-systolic pressure-volume relation
Right: a decrease in LV compliance as indicated by an increase in the position of the end-diastolic pressure-volume relation
These diagrams emphasize that heart failure may result from LV systolic or diastolic dysfunction independently
5
List some common causes of Left Ventricular Diastolic Dysfxn
8
LV End- diastolic dysfunction or delay in relaxation which is considered a form of “active stiffening” is complicated by
Failure of the actin-myosin disassociation, which occurs due to inadequate perfusion or dysfunctional intracellular Ca++ homeostasis
9
Causes of LV relaxation
Due to afterload, which is elevated in hypertensive pts. Tachycardia exacerbates the failure of LV relaxation.
9
What is commonly seen w/ HFpEF despite having only a modestly depressed LV systolic fx?
Profound exercise intolerance
9