EXAM 4 Flashcards
In cellular communication, the first step of signaling pathway in which a signaling molecule is detected by a receptor molecule on or in the cell
Reception
In cell communication the conversion of a signal from outside the cell to a from that can bring about a specific cellular response
Transduction
In a cellular communication, the change in a specific cellular activity brought about by a transduced signal from outside the cell
Response
The signaling molecule that binds to a receptor
Ligand
Referring to a secreted molecule that acts on a neighboring cell
Paracrine signaling
Signals released from the end of a neuron, diffuse across a short space and bind to a target cell, triggering a response.
Synaptic signaling
Signaling by secreted chemicals that are formed in specialized endocrine cells, travels in body fluids, and act on specific target cells
Hormonal signaling
Signal Transduction Pathway diagram (pg216)
A: Reception B: Transduction C: Response D: Plasma membrane E: Signaling molecule (Ligand) F: receptor G: relay molecules
The enzymes that transfer phosphates from ATP to protein often activating the target protein, a process called phosphorylation
Protein kinases
The enzymes that remove the phosphates from proteins often deactivating the target protein, a process called dephosphorylation
Protein phosphatases
A series of chemical reactions during cell signaling mediated by kinases, in which each kinase in turn phosphorylates and activates another
Phosphorylation Cascade
Signal transduction enzyme cascades can increase the cell’s response by activating products much more than in the preceding step
amplification of the signal
Different kinds of cells have different collections of proteins and these different proteins allow cells to detect and respond to different signals
Specificity of the response
For an organism to remain capable of responding to incoming signals, each molecular change in its signaling pathways must last only a short time.
termination of the signal
Large relay proteins to which other relay proteins are attached that increase the signal transduction efficiency by grouping together different proteins
scaffolding proteins
A type of programmed cell death, which is brought about by activation of caspase enzymes
apoptosis
Which of the following best describes hormone signaling
Specialized endocrine cells release signal molecules into the circulatory system, permitting distant cells to be affected.
The three stages of signal transduction in a cell are
signal reception, signal transduction, and cellular response
One type of cell signaling is called paracrine signaling. This type of signaling
involves secreting cells acting on nearby target cells by discharging a local regulator into the extracellular fluid
Growth factors often bind to receptors called
receptor tyrosine kinases
Just after a receptor tyrosine kinase binds to a signal molecule
dimerization and phosphorylation occurs
A phosphorylation cascade uses ___ as the source of phosphate for signaling.
ATP
At the end of the Receptor Tyrosine Kinase signaling pathway a transcription factor is turned on. This will directly cause
the synthesis of mRNA
Signaling through elaborate phosphorylation cascades of several kinases is beneficial to a cell because
it amplifies the original signal manyfold
The type of protein that terminates signaling through a phosphorylation cascade by performing dephosphorylation is a(n)
phosphatase
Apoptosis involves all except which of the following?
lysis of the cell
The process of turning genes on and off that ensures the appropriate genes are expressed at the proper times. This process can also help an organism respond to its environment.
Gene regulation
A cluster of functionally related genes can be under coordinated control by a single “on-off switch”
Operon
A regulatory “switch” that is a segment of DNA usually positioned within the promoter
Operator
A protein that can switch off the operon by binding to the operator and blocking RNA polymerase
Repressor (Lac Repressor)
A molecule that inactivates the repressor to turn an operon on
Inducer (allolactose)
A protein that can increase gene expression for an operon
Activator (CRP)
When glucose (a preferred food source of E. coli) is scarce, CRP is activated by this small molecule
Cyclic AMP (cAMP)
Lac Operon
A: DNA B: mRNA C: Proteins D: Inducer E: Lacl Repressor F: Lac Operon G: Regulatory gene H: RNA polymerase I: Operator
Expression of different genes by cells with the same genome resulting in differences between cell types.
Differential Gene Expression
Distal gene regulation control elements in eukaryotic cells that may be far away from a gene or even located in an intron
Enhancers
The developmental process that irreversibly commits a cell to becoming a particular cell type
Determination
The process by which cells become specialized in structure and function
Cell Differentiation
Normal cellular genes that are responsible for normal cell growth and division that can be mutated to increase cell division and cause cancer
Proto-oncogenes
Cancer-causing mutated genes that promote excess cell division like mutated ras
Oncogenes
Genes that prevent uncontrolled cell growth that can be mutated to contribute to cancer like p53
tumor-suppressor gene
The idea that multiple mutations are generally needed to cause full-fledged cancer; thus the incidence increases with age
Multi step model of cancer
The type of gene that produces repressor and activator proteins
Regulatory gene (lacl)
In bacteria, a set of genes that is controlled as a single unit is called a(n)
operon
The LacI repressor protein blocks transcription of the lac operon by binding to which of these?
the operator
For the lac operon, the repressor protein is deactivated when the ___ is present inside the cell increasing the amount of lac operon transcription .
inducer
Which of these turns on a eukaryotic gene by binding to an enhancer?
Activator
In both prokaryotes and eukaryotes, which of the following is an important part of gene regulation?
controlling the attachment on RNA polymerase to the promoter
All of the different types of cells in a person come from the one cell created by fertilization; the fusion of an egg cell with a sperm cell. Amazingly, almost all of the cells in us have all of the DNA that was in that original cell but are cells become very different from one another. What process below makes our cells distinct even though they have the same genes?
differential gene expression
The process that makes cells become more specialized in structure and function like muscle cells is called
cell differentiation
As people get older their risk of cancer increases because
the longer we live, the more mutations accumulate
Cancer is caused by changes in specific types of genes. Which of the genetic changes below is most likely to cause cancer in a person?
mutations in proto-oncogenes and inactivation of a tumor suppressor gene
In breast cells the receptor tyrosine kinase HER2 is expressed and responds to growth factors causing cell division. A new therapeutic called Herceptin binds to HER2 and inhibits signaling. Herceptin should be used to treat breast cancer under which of these circumstances?
If patient’s cancer cells have high levels of HER2
The branch of biology concerned with classifying and naming organisms
Taxonomy
Remains or traces of organisms from the past, usually found in sedimentary rock
Fossils
The study of fossils, that was largely developed by French scientist Georges Cuvier
Paleontology
Favorable inherited traits for the environment a species live in
Adaptations
A process in which individuals with favorable inherited traits are more likely to survive and reproduce
Natural selection
The process in which humans have modified other species by selecting and breeding individuals with desired traits.
Artificial selections
Argument for Natural selection:
Individuals in a population___ identical in their heritable characteristics
Organisms produce _____ offspring than the environment can support
Individuals that are more suited to their environment tend to leave ____ offspring than other individuals
Over time, ____ traits accumulate in the population
Vary
More
More
Favorable
Similarity between organisms resulting from common ancestry
Homology
Remnants of features that served important functions in the organisms ancestors
Vestigial traits
Is the evolution of similar, or analogous, features in distantly related groups
Convergent Evolution
Depiction of the hypothesis about the relationships among different groups and show that homolgies form nested patterns
Evolutionary trees
The history of life on earth written in the remains of organisms that is evidence of the extinction of species, and changes within groups over time
Fossil record
The geographic distribution of species, provides evidence of evolution
Bio geography
Layers of sedimentary rock that can contain fossils
Strata
Charles Darwin made important contributions to our understanding of how populations evolve but he did not discover everything. Of the statements below, which is correct about Darwin’s contributions?
He proposed natural selection as the mechanism of evolution
Which of the following people below was the first scientist to recognize that evolutionary change explains patterns in fossils and the match of organisms to their environments but incorrectly proposed that the mechanism for evolution was the use and disuse of traits.
Lamarck
Darwin incorporated which of these ideas from Malthus into his mechanism of natural selection?
populations tend to increase at a faster rate than their food supply normally allows
Before Darwin published On the Origin of Species most biologists thought that animals and plants never changed and each species was independent and unrelated to any other species. However, during the time that Darwin lived, observations of fossils and homologous structures in living organisms showing underlying similarities specifically suggested to biologists that ___ .
dissimilar organisms might have evolved from a distant, common ancestor
You can summarize the scientific theory of evolution as
an overarching explanation, supported by much evidence, for how populations change overtime
Darwin developed the mechanism of natural selection to explain how evolution happens. Which of the options below best describes the mechanism of natural selection?
Organisms better adapted to their immediate environment are most likely to survive and reproduce
The mechanism of natural selection relies on ___ to determine which traits will be successful.
the environment
Given a population that contains genetic variation, what is the correct sequence of the following events, under the influence of natural selection?
Genetic frequencies within the population change. Poorly adapted individuals have decreased survivorship. A change occurs in the environment. Well-adapted individuals leave more offspring than do poorly adapted individuals.
3-2-4-1
On an island, a species of rabbit has two fur colors, tan and gray. One population of rabbits lives on the western side of the island where there are gray rocky beaches and another rabbit population lives on the eastern side of the island where there are tan sandy beaches. A species of falcon on the island is constantly hunting the rabbits. On this island, natural selection will cause which of the following to occur?
Since tan rabbits blend better with the sandy beaches and gray rabbits blend better with the rocky beaches, the amount of tan rabbits will increase on the east side of the island and the number of gray rabbits will increase on the west side of the island.