Exam 3 Spring 2025 Flashcards
Acne, Hair loss, Scaly Dermatoses, Dermatitis, Wounds, and Burns
Define closed comedo.
White head
Define open comedo.
Black head due to oxidized lipids.
Define a papule.
Enlarged comedo with redness and inflammation
Define pustule.
Papule filled with pus.
What is a nodule/cyst?
These are painful lumps under the skin that are formed when the follicular wall ruptures and it can cause scarring.
Why does our skin have sebum?
Sebum is an oily, waxy substance that is produced by the sebaceous glands that is used to moisturize the exam.
What is the difference between acne and rosacea?
Rosacea will present with redness and flushing but no comedones will be presents while acne will have redness and maybe some flushing and obviously redness.
Which level can acne can be treated OTC?
Mild acne (not moderate or severe)
Define mild acne.
A few non-inflamed blackheads or whiteheads or a moderate number of mildly irritate pimples.
What hormone stimulates acne?
Dihydroxytestosterone
Increased levels of testosterone increases activity of what 2 things?
Increased sebaceous gland activity and abnormal follicular desquamation
What bacteria can colonize on the skin and lead to more inflammation and acne?
P. acnes
What are some acne exacerbating factors?
Oil-based cosmetics, friction on face, excessive contact between face and hands, chlorine, drugs (steroids, lithium, phenytoin), hormones, prolonged sweating, high humidity, stress, and possible genetics and diet
What are some medications that can exacerbate acne?
Steroids, lithium, and phenytoin
T or F: There is a cure for acne.
False. There is no cure for acne
What is the goal for OTC treatment of acne?
Reduce the frequency of the acne and severity of lesions and prevent scarring.
What are the 4 exclusions for self-treatment for acne?
- moderate to severe acne
- comedogenic drug use
- possible rosacea
- no improvement afters 6 weeks of treatment (12 weeks with adapalene)
What are some non-pharm options for acne treatment?
- eliminate exacerbating factors
- cleanse sin with mild soap 2 or less times per day
- limit high glycemic index foods
- pore strips (temporary usefulness)
What are the 6 available OTC medications for acne?
- Adapalene 0.1% (Differin gel)
- Benzoyl peroxide 2.5-10%
- Azelaic acid 10-14%
- Salicylic acid 0.5-2%
- Sulfur 3-10%
- Sulfur + resorcinol 2-3%
What are the two first-line option for OTC acne?
Adapalene 0.1% gel and Benzoyl Peroxide (2.5-10%)
What is the brand name for adapalene 0.1% gel?
Differin gel
What drug class is adapelene 0.1% gel?
Topical retinoid
What is the MOA of adapelene 0.1% gel?
Regulates epithelial cell turnover and reduces inflammation
T or F: Adapelene 0.1% gel bleaches things.
False. It does not bleach clothing.