Exam 3 Material Flashcards
Name the 4 compartments of the 4 compartment model for body composition.
- Water
- Mineral
- Protein
- Fat
Compare and contrast essential fat, storage fat, visceral fat, and subcutaneous.
- Essential fat for organ function vs. storage fat for energy reserve
- Visceral fat around organs vs. subcutaneous fat under the skin
Describe 3 changes in body composition in adulthood.
- Maximize bone density by age 30; start gradual loss about age 40
- Muscle strength peaks at age 25-30; maintain as age via exercise
- Positive energy balance at age 20-64; increase in adiposity with decrease in muscle mass
- in middle adulthood more fat shifts toward visceral, away from subcutaneous
Describe the set-point theory and how the body responds to over- and underfeeding.
- Body will defend against weight gain or loss
- better at preventing weight loss than weight gain - Overfeeding: causes hypophagia (reduced food intake) and higher metabolic rate
- Underfeeding: causes hyperphagia (increased food intake) and lower metabolic rate
State how the eating behaviors of adults differ from younger people.
- Adults are less responsive to variation in calorie intake as they age.
- Depends on other cues such as usual eating schedule, portion served, and emotional eating
Identify disease processes that are associated with obesity.
- Heart disease
- DM 2
- Hypertension (HTN)
- Stroke (CVA)
- Gallbladder disease
- Infertility
- Sleep apnea
- Hormonal cancers (prostate, ovarian, breast, endometrial)
- Osteoarthritis
- Metabolic syndrome
Name weight loss goals and calorie intake recommendations for people wanting to lose weight.
- Encourage gradual weight loss
- overweight: 0.5-1# / week
- obese: 1-2# / week - Negative energy balance to limit protein loss, maximize fat loss, esp when combined with exercise (~500 kcal/day)
- women: not less than 1200 kcal
- men: not less than 1500 kcal
Define the 4 given components of behavior modification, and give examples of each.
- Stimulus control
- settings/events that cause eating
- foods consumed when eating occurs
- consequences of eating - Problem solving proactively
- Cognitive restructuring
- identify, challenging, and correcting negative thoughts - Self-monitoring
- food diaries (+/- feelings about eating)
- weekly weigh ins
Name 4 categories of dietary modification for weight loss
- Restricted-energy diets
- Formula diets and meal replacement programs
- —limited long term behavior modification - Extreme energy restriction/fasting
- —promise quick results, often body water loss
- —elimination diets: high probability of muscle loss and inadequate micronutrients - Very-Low-Calorie Diets (VLCD): 200-800 kcal
Explain why fad diets or extreme energy restriction are discouraged.
- Fad diets: promise quick/dramatic results, often body water loss, usually elimination diets, high probability of muscle loss+inadequate micronutrients
- VLCD: needs medical supervision!
State the recommendations for physical activity with weight loss, including time requirements and types of activity.
- USDA rec: 60-90 min/day for weight loss/maintenance
- Combination of aerobic (cardio) and resistance (weight) training
- aerobic burns kcals stores, fat
- weight increases muscle mass, increases RMR
Identify patients who are candidates for bariatric surgery.
- BMI > 40
2. BMI > 35 + complications
Classify types of bariatric surgery as restrictive and/or malabsorptive.
- Restrictive: gastric banding
2. Restrictive+malabsoptive: rou-en-y gastric bypass (RYGB)
Define weight loss plateau.
When weight loss halts and weight remains stable for extended period of time.
Name the 4 behaviors associated with maintaining weight loss, according to the National Weight Control Registry.
- Relatively low-fat diet (24% kcal/fat)
- Participate in physical activity (60-90 min/day)
- Weigh once a week
- Eat breakfast
Name the caloric content of alcohol, and what constitutes a standard drink (including pure ETOH, beer, wine, and hard liquor).
- Caloric content: 7 kcal/g
- Standard drink:
- pure ETOH: 0.6 oz (15 g)
- beer: 12 oz
- wine: 5 oz
- 80-proof distilled spirits: 1.5 oz
Describe the Dietary Guidelines for Americans’ stance on alcohol consumption.
If you drink alcoholic beverages, do so in moderation.
- no more than 1 drink/day for women
- no more than 2 drink/day for men
Define binge drinking, heavy drinking, and excessive drinking for men and women.
- Binge drinking:
- Women: 4+ drinks on one occasion
- Men: 5+ drinks on one occasion - Heavy drinking:
- Women: >1 drink/day on average
- Men: >2 drinks/day - “Excessive drinking”:
- heavy drinking, binge drinking, or both
Identify when alcohol is associated with health benefits and when it is associated with health risks.
- Moderate alcohol consumption is associated with health benefits.
- Excessive drinking is associated with health risks.
List the 6 groups of people who should not consume alcohol, according to the Dietary Guidelines.
- Ind who cannot restrict their drinking to moderate levels
- Anyone younger than drinking age
- Women who are pregnant or who may be pregnant
- Ind taking prescription or OTC medications that can interact with alcohol
- Ind. with certain specific medical conditions (liver disease, hypertriglyceridemia,pancreatitis)
- Ind who plan to drive, operate machinery, or take part in other activities that require attention, skill, or coordination or in situations where impaired judement could cause injury or death (eg swimming)
Describe how alcohol causes cellular damage.
rapidly absorbed via simple diffusion –> rapidly distributed between intracellular/extracellular compartments–>
crosses plasma membranes–> denatures proteins (large, frequent ETOH damage proteins within and around cells)
Explain how alcohol tolerance develops.
High consumption activates secondary metabolism: microsomal ethanol oxidizing system (MEOS)
- pathway used for excessive amount ETOH
- treats ETOH as a foreign substance
- activation increases alcohol tolerance
- requires energy
Describe how alcohol spills into the bloodstream and causes the effects of drunkenness.
Only certain amount of ETOH can be metabolized/hr, this creates a bottleneck effect and ETOH spills into the bloodstream.
Name the effect of caffeine on alcohol metabolism.
- There is no effect on metabolism.
2. It does, however, mask depressant effect of alcohol and is associated with more binge drinking.
Explain why the liver is most harmed by alcoholism.
- Because ETOH is taken to the liver by portal blood.
2. Gut cells are damaged but have a shorter half-life so they regenerate, liver cells do not repair as readily
Define “functional food.”
“A food that has a health benefit beyond basic nutrition”
Define “dietary supplement.”
- a vitamin
- a mineral
- an herb or other botanical
- an amino acid
- a dietary substance for use by man to supplement the diet by increasing the total dietary intake (eg enzymes, or tissues from organs or glands)
- a concentrate, metabolite, constituent or extract
Describe when the FDA approves drugs and compare that to when the FDA approves supplements.
- Drug approval process:
- Phase 1: discover adverse events in healthy volunteers
- Phase 2: test for efficacy in small number of patients with target disease
- Phase 3: determine safety, efficacy, and dosage
- FDA approval
- Phase 4: postmarket, lrg populations, long-term effects
2: Supplements:
- No FDA approval process before supplement goes to market
- Once on market, FDA monitors safety
- FDA can take action if supplement demonstrated to be unsafe (warning, legal action, require removal from marketplace)
- 2007 FDA established the Good Manufacturing Practices (CGMPs)
Name 4 groups of people who should not use supplements.
- Pregnant or nursing women
- Children
- People with liver disease
- People taking medications that commonly interact with herbs, like anticoagulants, anticonvulsants, anti-rejection meds, HIV treatment
List 3 categories of supplements which are most likely to be contaminated or contain ingredients not listed on the label.
- Sports performance
- Weight loss
- Fen-Phen - Sexual enhancement
- contaminated with steroids, Viagra
Identify 5 strategies to minimize risk when purchasing supplements.
- Look for USP label (voluntary testing)
- Buy from large companies, not online-only
- Ask the in-store pharmacist
- Know what you are buying and why–research before you go! Don’t rely on people at the store!
- Look it up at www.NCCAM.NIH.gov
Name the average life expectancy and life span for Americans
Average life expectancy
-78.5 years (has increased)
Human lifespan
-110-120 years (pretty stable)
Old
- age 60
- DRI’s begin to decrease at age 70
Describe two basic theories on aging
Programmed aging
- predetermination
- cells can replicate X number of times before they die
- tend to die of a diseased process first
- –hearts disease, cancer, stroke, diabetes
Wear and tear
- accumulated damage
- years of damage eventually cause death
Name 3 changes in body composition as adults age
- Increase fat mass
- -visceral fat increases from 14% (age 20) to 30% (age 70)
- -not necessarily gaining weight, just losing muscle - Lose body water
- -easily dehydrated
- 61% in your 20’s to 53% in your 70’s - Lose lean body mass
- -2-3% every 10 years between the ages of 30-70
- -19% in your 20’s to 12% in your 40’s