Exam 3 lecture 4 Flashcards

1
Q

What is the most common indication for antibiotics in children

A

AOM (acute otitis media)

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2
Q

Risk factors that cause AOM

A

Smoke exposure
forumla feeding (breast milk is protective)\
Immunization
Atopy
Daycare attendance
Male gender
FH
Onset of 1st episode before 6-12 months of age
Lower socioeconomic status
Immune deficiency
non hispanic white

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3
Q

compare acute otitis media (AOM) and otitis media with effusion (OME) (when are antibiotics indicated? What tyoe of infection is seen)

A

Antibiotics not indicated and not beneficial in OME
Antibiotics indicated if symptomatic in AOM

Middle ear is sterile in OME, no signs of acute infection
Bacterual infection likely in AOM

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4
Q

What is a major reason children are more at risk for acute otitis media

A

Infant eustachian tube is shorter, more flexible and more horizontal vs adult (harder to drain)

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5
Q

Explain pathogenesis of acute otitis media? What percent of AOM are pathogenic bacteria isolated from?

A

Ineffective aeration of middle ear space-> Eustachian tube dysfuncion.

This leads to inflammation and edema of mucosal linings and narrowing of eustachian tube lumen.

Trapped air creates vacuum reversing flow of secretions drawing fluid into middle ear

Bacteria mutiply in fluid and stimulate inflammation

Pathogenic bacteria isolated from 65-75% of AOM cases

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6
Q

What are more common microorganisms seen with AOM? What are the big 3

A

strep pneumo, haemophilus influenza, mraxella catarrhalis (big 3)

Strep pyo and no pathogen is also common

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7
Q

What is the timeline of pneumococcal vaccination in children

A

Usually given 2, 4, 6 and 12-15 months

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8
Q

clinical manifestations of AOM in children

A

Otalgia (ear pan)
Holding or tugging at ear
Fever
irritability
poor feeding/anorexia
Malaise
otorrhea

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9
Q

How to diagnose AOM

A
  1. Visualize tympanic membrane
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10
Q

Compare normal TM and TM in AOM

A
  1. Normal TM
    slightly concave
    Pearly gray in collor
    Translucent
    Moves in response to pressure
  2. TM in AOM
    -bulging
    -cloudy or purulent effusion
    Immobile
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11
Q

2 important things to note about diagnosis of AOM

A
  • acute onset (onset needs to be acute)
  • ## Middle ear effusion
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12
Q

What are criteria that we use to determine if a patient has severe or non severe disease

A

non severe- Mild otalgia AND Fever <39 C in past 24 hrs

Severe- Moderate to severe otalgi or Fever > 39

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13
Q

What does effusion mean

A

Fluid collection

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14
Q

What are the criteria for observation Vs treatment of AOM

A

If <6 months- treat in every situation (otorrhea, severe uni &bi, Non severe uni & bi)

For 6 months-2 yrs- Treat in otorrhea, severe uni & bi, Bilateral non severe, but OBSERVE unilateral non severe

For > or = 2 yrs- Treat in severe bi anduni and otorrhea, But not in non severe at ALL

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15
Q

What does observation option look like in AOT

A

Deferment of antibiotics for 48-72 hrs
Watch for resolution of symptoms.
provide symptomatic relief

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16
Q

What to do in case observation fails

A

Communicate with physician
Begin antimicrobial therapy
Continue symptomatic therapy

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17
Q

What are SNAPs

A

Safety net antibiotic prescription?

Parents will allow 1-2 days for infection to resolve. If baby not better they can fill it

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18
Q

Describe strep pneumo resistance ( How common, Why, How to overcome)

A

50% of strains are penicillin resistant
Due to alterations in penicillin binding proteins
Overcome by higher concentrations of antibiotic at site (high dose amox

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19
Q

Describe H influenzae & moraxella catarrhalis resistance (how common and how to overcome)

A

40-50% of H flu strains and almost all M cattarhalis strains produce B lactamase (lead to amox resistance)

Overcome by addition of B lactamase inhibitor (such as amox/clav)

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20
Q

What is 1st line for AOM? Dose? (exam)

A

Amoxicillin is 1st line

80-90 mg/kg/day divided Q12H X 5-10 days

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21
Q

What are some advantages of using amoxicillin for AOM

A

In middle ear, high dose amox concentrations exceeds MIC of S. pneumo strains resistant to penicillin

Safe effective inexpensive

Half life 4-6 hrs in middle ear

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22
Q

When do we NOT use amoxicillin (exam)

A

Known resistance
tx failure
AMox in last 30 days
Allergy
Concurrent conjuctivitis

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23
Q

2nd line after amox failure in AOM?

A

Amox clav (augmentin)

1st line if amox in last 30 days or had conjuctivitis

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24
Q

Dose of amox clav? advantage/disadvantage?

A

90 mg/kg/day amox divided Q12H?

Advantage- additional coverage for B lactamase producing organisms

Disadvantages- may be more expensive
Diarrhea associated with clavulanate

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25
Q

Which augmentin to use for AOM

A

600 mg amox/42.9 mg clav/ 5 ml

ES- 600

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26
Q

What is the goal clavulanate for AOM

A

under 10 mg/kg/day

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27
Q

What would we use as 2nd-3rd line tx against AOM? What soecific drugs?

A

Oralcephalosporins

Cefpodoxime
(3rd gen cephalosporin)

Cefdinir
(3rd gen cephalosporin)

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28
Q

Describe allergies and cross reactivity when treating AOM

A

Cross reactivity highest between penicillins and 1st gen cephalopsorins

Much lower with 2nd and 3rd gen cephalosporins (cefdinir, cefuroxime, cefpodixime, ceftriaxone

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29
Q

What is the use of ceftriaxone in AOM? ROA?

A

Used as 3rd line. Used if initial oral tx fails or is not an option.

IM injection

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30
Q

advantages/disadvantages of ceftriaxone

A

advantage- broad spectrum, as effective as 10 days of amoxicillin

Disadvantages- Inj site pain, cost, avoid in < 1 month of age

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31
Q

What are some cautions with ceftriaxone

A

Calcium co administration
C diff

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32
Q

duration for children under 2 years old? Over 2 years old?

A

Under- 10 day duration
Over- 10 days if severe or recurrent, shorter courses (5-7) days may be used if >2 years

33
Q

Adjunctive therapy for AOM (drugs, dose and age)

A
  1. Analgesics
    - APAP PO
    10-15 mg/kg/dose Q4-6H
  • ibuprofen PO
    5-10 mg/kg/dose Q 6-8H if older than 6 months ONLY
  1. Lidocaine otic drops
    May consider in children 2 and up, do not use in ruptured TM or tubs, 2-4 drops in affected ear TID-QID
34
Q

What does follow up look like for AOM

A

Within days for young infants with severe episodes or children of any age with continuing pain

Within 2 wks for infants or young children with hx of frequent recurrences

1 month after initial examination for children with only a sporadic episode of AOM

No follow up necessary for older kids

35
Q

What are some preventions for AOM

A

pneumococcal and influenza vaccinations
Reduction of preventable risk factors

36
Q

What are tympanostomy tubes? When are they indicaged?

A

Small ventilation tube inserted through tympanic membrane to provide drainage for eustachian tubes

Indivated in recurrent AOM
- 3 or more episodes in <6 mo
- 4 or more episodes in < 12 mo

37
Q

advantages/disadvantages of tympanostomy tubes

A

Advantages- decrease AOM by 50%
- help restore hearing

Disadvantage- have to be placed under anesthesia
Can lead to scarring of tympanic membrane

38
Q

If a patient has AOM, when should we consider ear drops

A

With tympanostomy tubes

39
Q

tx of uncomplicated otorrhea with tympanostomy tubes

A

Topical quinolone drops are better than oral therapy
Oflafloxacin, ciprofloxacin

4-5 drops in affected ear BID x 5-7 days

40
Q

What happens if we use tubes in pts without tubes

A

Topical quinolones can increase risk of perforation in pts without tubes

41
Q

What is CSOM? What is it characterized by?

A

Chronic suppurative otitis media

Most severe form

Characterized by perforated TM w persistent drainage lasting >6wks

42
Q

Most common isolate with CSOM

43
Q

Where does CSOM come from usually? What may it cause? Treatment?

A

Can be a complication of tympanostomy tube

May result in abscess or hearing loss

Initial tx ofloxacin or cipro ear drops x 2 weeks

44
Q

What to do if tx failure of CSOM

A

Cukture is indicated and potentially requiring IV therapy or surgery

45
Q

acute otitis externa other name? What can cause it?

A

Swimmers ear

Can be caused by trauma or trapped moisture

46
Q

What are organisms seen in acute otitis extera

A

Different from AOM

Pseudomonas, S. aureus, consider fungal if no improvement)

47
Q

How to treat acute otitis externa

A

Polymyxin B, Neomycin and hydrocortisone

Ofloxacin

Ciprofloxacin with hydrocortisone

48
Q

Risk factors in febrile infants for UTI for girls and boys

A

Girls
- white
Age < 12 months
Temp > or =39
Fever > or = 2 days
Absence of another source of infection

Boys
- non black race
Temp > or = 39
Fever > or = 24 hours
Uncircumsized
Absence if another source of infection

49
Q

Pathogenesis of UTI

A

Retrograde ascent
Nosocomial infection
Hemoatogenous spread
Fistula formation

50
Q

common pathogens with UTI

51
Q

signs/symptoms/diagnosis of UTI in newborns? Infants/young children? School aged children?

A

Newborns- Jaundice, sepsis, failure to thrive, vomiting, fever

Infants/ young children- Fever, strong smelling urine, hematuria, Abdominal/flank pain, new onset urinary incontinence

School aged children- Sx similar to adults including Dysuria, frequency urgency

52
Q

Name methods of urine collection? Describe them?

A

-Clean catch- older patients
-Catheterization- Preferred for <24 months
-Sura pybic aspiration (SPA)- gold standard but invasive (reserved for young children who failed catheterization)
-Bag specimen- High rates of false postives.

53
Q

What do we look for in a urinalysis? Chances of false positive/negative?

A

Leukocyte esterase suggest inflammation
Nitrite

When nitrite and leukocyte esterase are both negative -> 100% predictive
When both pisitive-> 80-90% sensitive and 60-98% specific

54
Q

Cut offs for positive urine culture

A

SPA>10,000

Catheter specimen> 10,000

Clean catch >100,000

55
Q

Treatment of UTI oral or IV? WHen would we use each

A

Oral and IV equally efficacious

Most patients can have oral

Choose IV for patients who are “toxic”, unable to retain oral intake

56
Q

When can we switch from IV to oral in UTI pts

57
Q

Duration of therapy for UTI

A

7 days for uncomplicated
Pyelonephritis- 10-14 days
7-14 days for ages 2-24 months

58
Q

Treatment options for UTI

A

cephalexin Q6 or Q8H

Amoxicillin traditionally 1st line (e coli makes beta lactamase, amox clav might be better choice; klebsiella makes beta lactamase as well)

Higher cure rates with TMN-SMX or amox clav

59
Q

When should we use each tx option for UTI

A

Amox/clav can target E coli that make B lactamase

SMX/TMP- E coli susceptibility varies

Nitrofurantoin- Must confirm ONLY cystitis. We can not use it in pyelo.

60
Q

Why do we not use nitrofurantoin in UTI

A

It is very hard to see if a child has pyelo

61
Q

Fluoroquinolones in chuldren UTI? Makor concern? When can they be used?

A

Traditionally not used in children.

Major concern is resistance

May be useful in MDR pathogens. Or if IV is not feasible or possile

62
Q

Follow up for UTI

A

COnsider renal/bladder ultrasounds in all boys, all girls <3 years old, girls 3-7 years with fever >38.5

63
Q

When can prophylaxis be used in UTI?

A

Some benefits seen with severe VUR (Vesicoureteral reflux)

64
Q

What is bronchiolitis? What is it characterized?

A

Caused by viral lower respiratory tract infection in infants and young children

Acute inflammation, edema, increased mucus

65
Q

clinical presentations of bronchiolitis? Duration to resolve?

A

Fever, Rhinorrhea, cough, sneezing

More severe sx can be increased work of breathing
- nasal flaring, accessory muscle breathing can progress to resp failure,

May take up to 2 wks to resolve?

66
Q

most common virus that causes bronchiolitis? 2nd most common?

A

1st- Respiratory syncytial virus (RSV)
Rhinovirus is 2nd

67
Q

How common is RSV?

A

90% of children infected before 24 mo.

68
Q

Risk factors for RSV?

A

Age<6 months
Pre-term birth
Cyanotic or complicated CHD
Chronic lung disease
Weakened immune system

69
Q

Treatment of RSV

A

SUPPORTIVE THERAPY (O2, hydration, mechanical ventilation, ECMO (life support))

70
Q

Prevention of RSV

A

Non pcol- Hand washing, isolation, sick pods

Pcol- Influenza vaccine, RSV specific (nirsevimab, maternal RSV vaccination)

71
Q

What are 2 ways to protect babies from severe RSV disease

A
  1. vaccination of pregnant people
  2. monoclonal antibody for infants (palivizumab, Nirsevumab)
72
Q

When should pregnant people get RSV immunization?

A

Abrysvo if delivered during RSV season (32-36 weeks pregnancy)
provides protection if given at least 14 days before delivery.

Administer before and during start of RSV szn (sept through jan)

73
Q

What to do if birth parent did not get RSV vaccination 14 days before deivery?

A

Give Nirsevimab.

Typically for < 8 mo of age

Only should be given during RSV season.

74
Q

Dosing of nirsevimab

A

<5kg=50 mg
5kg or more =100 mg

75
Q

How long does nirsevimab last

A

71 days (lasts longer than RSV vaccine)

76
Q

Timing of Nirsevimab

A

If born during RSV szn, get it in the hospital

If born outside of RSV szn(summer) get it at the PCP when the season starts

77
Q

Who needs second nirsevimab dose?

A

Chronic lung disease
Immunosuppressed
American indian or alaska native