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Reproduction > Exam 3 Lecture 3 > Flashcards

Exam 3 Lecture 3 Flashcards

1
Q

Clear Blue Fertility Mointor

A

-typically IDs up to 6 fertile days
detects both LG & estrogen
- very accurate
- for women whose natural cycle lasts 21-42 days
- should be off OCs for at leasr 2 cycles
- use first urine sample in AM

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2
Q

fertility scope

A
  • detects estrogen in saliva (peaks on ovulation day)
  • uses an optical lens
  • requires visual interpretation by user
  • can be used in women w/ irregular period
  • can be affected by eating, drinking, brushing teeth, smoking
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3
Q

first response fertility test

A
  • measures FSH on day 3 of cycle (day 1= 1st day of bleeding)
  • urine sample
  • tests fertility NOT ovulation
  • do not use if taken OCs w/in 60 days
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4
Q

First response daily digital ovulation test

A
  • measures LH surge
  • similar to clean blue
  • urine
  • test at the same time every day
  • do not urinate for at least 2 hours prior to testing
  • easy “yes” or “no” display
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5
Q

OvWatch

A
  • wrist, biosensing medical device
  • detects transdermal hormone induce Cl ion fluctuations
  • CL ions surge indicates fertile window
  • most expensive
  • notifies pt 4 days before ovulation
  • do not use if taking OCs
  • begin wearing the 1, 2, or 3rd day of menses
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6
Q

ovulation induction

A

stimulate growth, maturation and ovulation of a single follicle

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7
Q

controlled ovarian hyperstimulation

A

stimulate growth and maturation of multiple follicles

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8
Q

clomiphene brand name

A

Clomid or Serophene

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9
Q

clomiphene MOA

A
  • inhibit estrogen binding at hypothalamus & pituitary gland preventing normal - feedback
  • incr. in FSH/LH release
  • promotes follicular growth & maturation
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10
Q

nonsteroidal estrogen receptor blocker

A

clomiphene

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11
Q

clomiphene dosing

A

50mg PO QD for 5 days, starting on day 2-5

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12
Q

aromatase inhibitor

A

lotrozole (Femoara)

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13
Q

Letrozole MOA

A
  • inhibits conversion of testosterone to estradiol

- decrease in estrogen stimulates release of FSH/LH

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14
Q

lotrozole dose

A

205-5mg QD for 5 days starting on day 3

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15
Q

monitoring with clomiphene & letrozole

A

monitor with ovulation prediction kits or ultrasound

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16
Q

third line infertility treatment

A

gonadotropin therapy

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17
Q

menotropins

hMG( Repronex, Menopur)

A

FSH & LH

18
Q

Urofollitropins

HP-FSH (Bravelle)

A

FSH only

19
Q

Follitropin alpha (Gonal-F), follitropin beta (Follistim AQ)

A

FSH only

20
Q

Lutropin alpha (Luveris)

A

LH only

21
Q

storage of gonadotropin therapy

A

powder can be stored in fridge or RT

22
Q

gonadotropin therapy side effects

A
  • male- breast enlargment
  • female- N/V, abd pain, breast tenderness, injection site rxn, HA, hot flashes,ovarian hyperstimulation syndrome, multiple gestations, ectopic prego
23
Q

hCG MOA

A

supplements LH to mimic LH surge

24
Q

hCG side effects

A

HA, irritability, restlessness, fatigue, edema, gynecomastia, injection site rxns

25
Q

hCG brand names

A 
- urine derived: Pregnyl, novarel
choriogonadotropin alpha (r-hCG): ovidrel
26
Q

female hCG dosing

A

5000-1000 units once given 3-4 days after last dose of clomiphene or one day after lst dose of gonadotropins
- have sex the day after hCG & for the next 2 days

27
Q

Male hCG dosing

A

for 2* hypogonadism

- 1000-2000 units TIW until serum testosterone are normal (2-3 months); may add gonadotropin & continue hCG

28
Q

hCG therapy is

A

additive (combined with something else)

29
Q

hCG storage

A
  • urine-derived: store powder at RT; pt must refrigerate after mixed
    e-hCG: refrigerate pre-filled syringe prior to dispensing; pt may keep at RT
30
Q

hCG therapy indication

A
  • females: ovulation induction with other agents; correct for lack of mid-cycle gonadotropin surge
  • male: spermatogenesis in men w/ hypogonadism
31
Q

GnRH nasal spray

A

synarel (nafarelin)

32
Q

GnRH side effects

A

stimulation: excessive ovarian stimulation & estrogen synthesis
suppression: estrogen deficiency

33
Q

GnRH storage

A

refrigerate injectables

store nasal spray at RT

34
Q

GnRH indications

A
  • women with anovulation due to GnRH deficiency
  • PCOS
  • off label in men to increase sperm count
35
Q

GnRH antagonist MOA

A

competes with natural GnRH for pituitary receprors-> immediate decrease in pituitary secretion of FSH/LH

36
Q

GnRH antagonist dosing

A
  • antagon: 250microg SC QD on day 8-9 of cycle until hCG administration
  • cetrotide: single or multiple dosing
  • should be used with hCG
37
Q

indication of GnRH antagonist therapy

A
  • suppress premature LH surge and premature ovulation during controled ovarian stimulation with menotropins
38
Q

OCs, estrogen and progesterone are used

A

before fertility treatments to help prepare the uterus

39
Q

DA agonists are used in

A

hyperprolactinemia

40
Q

metformin used in

A

PCOS associated insulin resistance

Reproduction (12 decks)

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