Exam 3 (Lec 19)

Question 1

What are the three evolution-proof therapies?

Answer 1

1. slow the emergence of resistance by using moderate doses and targeting particular age classes
2. Phage therapy
3. Disrupt bacterial communications by introducing cheaters

Question 2

What are the effects of “1. don’t wipe out the competition”?

Answer 2

• use no more selection than is absolutely necessary to cute the patient
• the preserves clones of less resistant pathogens that compete and suppress the more resistant ones
• this slows the evolution of resistance

Question 3

What are the advantages of phage therapy?

Answer 3

• reduces the chance that good bacteria are killed
• a small initial dose of phage will multiply as they infect bacteria, diminishing the need for repeated administrations
• phage also mutate during replication, as do bacteria, producing new phages that recognize altered bacteria

Question 4

When was phage discovered?

Answer 4

1915

Question 5

While the US and other Western countries invested in antibiotics, which country developed phage to treat bacteria?

Answer 5

Russians

Question 6

How is “3. Disrupt bacterial communications by introducing cheaters” done?

Answer 6

1. cheats do not produce public goods and will die out
2. cheats can be trojan horses