Exam 3 inclass examples Flashcards

1
Q

Macrophage activation by Th1 cells is an important immune mechanism for eliminating bacteria which can resist……

A

lysosomal degradation

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2
Q

T-Cells which activate macrophages do all of the following except.

A

provide granzymes that the macrophages use to kill it.

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3
Q

Th1 cells make IL-3 and GM-CSF which:

A

stimulate macrophage production in the bone marrow.

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4
Q

Which of the following statements about primary and secondary antibody responses is NOT true?

A

Primary responses are characterized by IgG antibodies, whereas secondary responses are dominated by IgM antibodies.

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5
Q

Which one of the following statements about humoral immune responses is true?

A

Naive B cells are required for initiation of primary responses and memory B-Cells are required for initiation of secondary responses.

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6
Q

Which of the following events does not occur withing germinal centers?

A

Ig Gene V(d)J recombination.

Extra note: Variable part of IgG recombines in bone marrow.

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7
Q

Which of the following antigenic structures might activate B-Cell antibody production without the aid of T-Cells?

A

ABO blood group antigen (oligosaccharide)

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8
Q

Which of the following statements accurately describes antigen recognition events in a lymph node during a helper T-Cell dependent antibody response to a protein antigen?

A

Naive B-cells recognize intact proteins, generate peptide fragments of these proteins, and present them in complexes with MHC molecules to differentiated helper T-cells

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9
Q

A 5-year-old boy has a history of recurrent pneumococcal pneumonia. Pneumocystis carinli pneumonia (PCP), and bacterial ear infection. His maternal uncle and an older brother experienced the same symptoms, but he has an older sister who is healthy. Laboratory studies indicate normal number of B cells and T cells, and the serum contains mostly IgM and very little IgG. Which of the following genes most likely contains a mutation in this patient?

A

CD40 and CD40L

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10
Q

The B cell receptor (BCR) complex and the signaling cascades to which it is linked share many similarities with the T cell receptor (TCR) complex and its linked signaling cascades. Which of the following comparisons between BCR and TCR signaling is NOT true?

A

CD4/CD8 coreceptors in T cell and the CR2 coreceptor in B cells both enhance responses to antigen by a PI3 kinase– dependent mechanism.

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11
Q

A 5-year-old boy has a history of recurrent pneumococcal pneumonia. Pneumocystis carinli pneumonia (PCP), and bacterial ear infection. His maternal uncle and an older brother experienced the same symptoms, but he has an older sister who is healthy. Laboratory studies indicate normal number of B cells and T cells, and the serum contains mostly IgM and very little IgG. Which of the follwing abnormalities would NOT be likely in this patient?

A

There is limited diversity in the repertoire of IgM antibodies produced.

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12
Q

Concerning the Fab region of an antibody molecule, which of the following is TRUE?

A

the Fab includes the entire V and C regions of the light chain.

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13
Q

Many cell surface molecules are important in the activation of B lymphocytes to produce antibody. Which of these is NOT however involved during the actual binding of B cells to the T helper cell surface?

A

Ig

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14
Q

IF you could analyze at the molecular level, a plasma cell making IgA antibody, you would find all of the following except…

A

mRNA specific for u(MU) heavy chains.

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15
Q

Within the germinal centers of secondary lymphoid organs

A

B cells expressing affinity for antigen are rescued from cell death by binding to antigen-binding complexes on follicular dendritic cells.

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16
Q

The mechanism most responsible for co-expression of IgM and IgD on the surface of a B cell clone is

A

Alternative RNA splicing.

17
Q

The switch from membrane bound to the secreted form of Ig involves

A

Alternative splicing and

Polyadenylation of mRNA which excludes the transmembrane coding sequences found in the genomic DNA

18
Q

Multiple myeloma is a cancer which has arisen from a

A

plasma cell

19
Q

Which of the following is TRUE about effector functions and immunoglobulins?

A

If B cell membrane Ig binds to soluble complexes of antigen and antibody, B cells may be down-regulated.

20
Q

Complementarity determining regions (CDR’s) of an immunoglobulin

A

determine antibody specificity and are found on both the heavy and the light chains.

21
Q

If you wanted to check for the presence of memory B cells from your vaccine ??????? by taking some of their B cells and re-stimulating them in vitro ????? antigen, the best place to get some memory cells would be from

A

blood

22
Q

After binding to its specific antigen, a B lymphocyte may switch to

A

Immunoglobulin heavy-chain class

23
Q

C3a and C5a can cause

A

vascular permeability

24
Q

Patients with severely reduced C3 levels tend to have

A

increased number of severe bacterial infections.

25
Q

Individuals with a genetic deficiency of C6 have

A

Decreased resistance to Neisseria bacteremia

26
Q

The membrane IgM and IgD on the surface of an individual B cell

A

are identical except for their CH regions.