Exam 3- Hypertension Therapeutics - Patel Flashcards
Thiazide/ Thiazide Like Diuretics MOA
inhibits NaCl transporter on DCT
Name the Thiazide/ Thiazide Like Diuretic.
HCTZ (Microzide)
12.5 - 25 mg QD
Name the AE’s associated with Thiazide/ Thiazide Like Diuretic and the associated monitoring parameters.
Decrease
Na
K, Mg
Increase Uric Acid glucose Ca TG's
Monitoring
BP, Na, K, glucose, TGs, Uric acid, SCr
What causes increased gout in patients that take Thiazide/ Thiazide Like Diuretics?
the increase in urea
Sexual dysfunction + photo sensitivity are associated w/ what type of drugs?
Thiazide/ Thiazide Like Diuretics
What happens if lithium is taken with HCTZ?
lithium clearance will decrease
What happens if you take HCTZ with a bile sequestrant?
HCTZ absorption will decrease
Name the clinical pearls associated with Thiazide/ Thiazide Like Diuretics. (3)
- gout
- sulfa allergy
- 25 mg max effective dose
ACEI MOA
Block ACE enzyme which blocks Angio I to Angio II conversion
Name the ACEI drugs
Lisinopril (Prinivil/Zestril): 10-40mg QD
What is the MOA for ACEI
blocks ACE enzyme which blocks Angio I to II conversion
Name the ACEI (REBL)
Ramipril (Altace)
Enalapril (Vasotec)
Benazepril (Lotensin)
Lisinopril (Prinivil/Zestril) : 10-40 mg QD
What ACEI has the lowest half-life? How is it excreted How does this effect dosage and compliance?
Captopril
Renally
Dosed frequently
Decreased compliance
What ACEIs are only dosed once day?
Fosinopril
Lisinopril
Trandolapril
Name the 2 major AEs associated w/ ACEIs.
Dry Cough
Angioedema
What causes the dry cough and angioedema associated with ACEIs? Others?
increased levels of bradykinin
Hypotension, K+ increase, SCr transient increase
What 3 monitoring parameters are associated w/ ACEIs
BP, K+, SCr
Hyperkalemia occurs more frequently in what group(s) of patients who are on an ACE inhibitor?
CKD patients
Patients taking K+, NSAIDs, K+ sparing diuretics
Type II diabetes + CKD
What prego category do ACEIs fall into?
Pregnancy D
What is the MOA of ARBs?
competitive inhibition of Angio-1 receptors
True/False
ACEIs + ARBs can be taking in conjunction.
False
- can not
Name the ARBs drugs.
Losartan (Cozaar): 50-100 mg in 1-2 doses (daily)
Olmesartan (Benicar)
Valsartan (Diovan)
True/False
The adverse event associated w/ ARBs are the same as?
ACEIs
- Prego- D
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