Exam 3 Cram Flashcards
What is important about Cis loop receptors
have 5 subunits
NMDA Coincidence Detector
Mg block needs depolarization and AMPA, require depolarization and glutamate
What is NMDA important for
long term potentiation
Ionotropic
GABA - A and GABA-C, leads to hyper polarization
what are the Two principal signal transduction pathways of G protein-coupled receptors:
the adenylyl cyclase – cAMP signal pathway, and the Phospholipase C
GQ- has two of what?
split pathways and you get DAG and IP3
Phosphorylation
adding phosphate group
What plays a primary role in ERK2
Serine and threonine
What are two transcription factors
Mapk and Creb
why do people administer L dopa in parkinsons
because it can cross blood brain barrier because dopamine cants
What is the role of NE arousal and stress
important in ADHD
Where does serotonin come from
tryptophan
Where are CB1 receptors expressed, and where are they found
Expressed In the brain, Found in adipose tissue, liver, muscle, intestines, pancreas
Where are CB2 receptors expressed
Expressed in immune cells
TRP channel function
Specialized Sensory Transducers, critical for pain sensing
TRPV1 is an
inflammation sensor
TRPM8 is activated by
menthol
TRPA1 is activated by
horseradish
what do antidepressants do
Block serotonin transporter
What are the nine catecholamines
Dopamin, norepinephrine, epinephrine, TH, AADC, DBH, PNMT, L-dopa, L-tyrosine
Where in the brain is dopamine found
Substantia Nigra, and VTA
Where in the brain is Norepinephrine found
Locus Coeruleus
Where in the brain is Epinephrine found
Medullary epinephrine neurons
Where in the brain is Serotonin found
raphe nuclei
