Exam 3 - Bipolar Disorder Flashcards
Which brands of aripiprazole are approved for management of bipolar disorder? (2)
Abilify Maintena and Asimtufii
Which brands of risperidone are approved for management of bipolar disorder? (2)
Risperidal Consta and Rykindo
Which brands of aripiprazole and risperidone are not approved for management of bipolar disorder? (2)
Aristada and Perseris
Which brand of risperidone is approved for both bipolar I maintenance and as adjunctive therapy?
Rykindo
What are the treatments for acute mania and mixed episodes in bipolar disorder? (10)
lithium, valproate, carbamazepine (IR+ER), aripiprazole, asenapine, cariprazine, olanzapaine, quetiapine, risperidone, ziprasidone
What are the treatments for maintenance in bipolar disorder? (7)
lithium, lamotrigine, aripiprazole, olanzapine, quetiapine, risperidone, ziprasidone
What are the treatments for acute depression monotherapy in bipolar disorder? (5)
cariprazine, lumateperone, lurasidone, olanzapine, quetiapine
With which medication classes are the risk of an affective switch higher? (2)
TCAs and SNRIs
What is the MOA and ROA of dexmedetomidine (Igalmi)?
A2A receptor agonist, sublingual film
Which type of patients do not respond well to lithium as to some anticonvulsants? (2)
rapid cyclers and mixed states
What is the MOA of lithium? (5)
inhibits phosphoinositide, decreases 5-HT reuptake, decreases DA synthesis, enhances GABA, decreases Ca2+ transport
What are AEs of lithium? (6)
polydipsia/uria (AKI/CKD), GI, muscle weakness/lethargy, cardiac effects (Brugada syndrome), hypothyroidism, dermatologic (acne)
What class of medications can be used for lithium-induced tremors?
beta blockers
What medications increase lithium levels? (3)
NSAIDs, ACEi/ARBs, thiazide diuretics
What medications decrease lithium levels? (2)
mannitol, methyl-xanthines (caffeine)
