Exam 3 Flashcards
What are the three main functions of mucous membranes?
- Absorption
- Excretion
- Protection
What are the masticatory (keratinized) mucosa?
- gingiva
- hard palate
What are the lining (non-keratinized) mucosa?
Alcohol By Volume? F*****g Sick
- alveolar
- buccal
- ventral surface of tongue
- floor of mouth
- soft palate
Specialized mucosa
-dorsal surface of tongue (taste buds)
What are the 4 layers of the mucous membranes?
- Epithelium
- Lamina propria
- Submucosa
- Periosteum
What is the mucous membrane called that is missing the submucosal layer?
-mucoperiosteum
Which tongue papilla has lymphoid tissue?
-foliate
What lesion has foamy histiocytes and typically is caused by trauma?
Mucoceole
What are von ebner glands?
-salivary glands associated with the circumvalate papilllae that secrete pure serous secretions to clear out taste buds to continue tasting.
Why might a tooth become ankylosed?
-trauma that destroys the PDL so only osteoblasts are available to head the damaged site.
What part of the palate is the “glandular zone”?
-posterior 1/2
What structure helps hold the epithelial layer to the connective tissue layer in mucous membranes?
Epithelial Rete Pegs
What is parakeratosis?
retention of pyknotic nuclei in the stratum corneum
What is hyperkeratosis?
abnormal thickening of the stratum corneum
What is dyskeratosis?
abnormal keratinization below the level of the stratum corneum. (within granulosum or spinosum)
Acanthosis
hyperplasia (more cells) of epithelial layer
acantholysis
loss of intercellular attachments between epithelial cells
Metaplasia
reversible switch from one adult cell type to another (like columnar to squamous in respiratory tract in smokers)
Dysplasia
disorderly growth by non-neoplastic growth of tissue (characterized by pleomorphism, hyperchromatism, loss of normal spatial org)
What cell has dendritic morphology and is located in the stratum spinosum (not basale?
Langerhans cells (is an antigen trap)
What cell has a rounded morph and is located in the stratum basale?
Merkel’s Cells
What cells has rounded morph and is located in the basale AND and spinosum?
Lymphocytes
The basement membrane is made up of what?
Basal Lamina (lamina lucida and lamina densa) + lamina reticularis
What are the two key components of the lamina lucida in the basal lamina>
- bullous pemphigoid antigen
- Type VII collagen
What are the two key components of the lamina densa in the basal lamina?
- Type IV collagen
- Type VII collagen
What is the resident cell pop of the lamina propria?
- fibroblast
- monocyte
- basophil
- plasma cell
- endothelial cell
What do Mast Cells do?
secrete inflammatory mediators like histamine and heparin
What do plasma cells do?
synthesis of immunoglobulins
What do neutrophils do?
phagocytic cell that neutralizes antigens
Taste Sensation for the Anterior 2/3 of tongue supplied by the…
Facial Nerve CN VII
Taste sensation for the posterior 1/3 of the tongue supplied by the…
Glossopharyngeal Nerve CN IX
Innervation for the soft palate is supplied by the….
facial nerve
Innervation for the walls of the pharynx and epiglottis is supplied by the…
vagus nerve CN X
What characteristic does lichen planus have?
T-lymphocyte and langerhans cell hyperplasia infiltration
What is benign inflammation and desquamation of the epithelial layer?
geographic tongue
Can leukoplakia be scraped off?
No
What is notable about leukoplakia?
It is considered precancerous
Most common site for oral squamous cell carcinoma?
posterior and lateral portion of tongue Male gender bias (3:1)
keratin pearls and invasive islands of malignant squamous epithelial cells are signs of…
squamous cell carcinoma
What is mucosal pemphigoid?
Accumulation of IgG and C3 along the basement membrane that causes separation of basement membrane layers since pemphigoid adhesion antigen is found in the lamina lucida. Female biased (2:1)
What is the Nikolsky sign?
Sign for pemphogoid where mucous membrane separates with light force
Condition where structures of ectodermal origin do not develop. What are these structures?
Ectodermal dysplasia: hair, eyebrows, eye lashes, teeth, sweat glands
What is a peripheral ossifying fibroma? Cancerous? What does it look like histologically/
-maturation of pyogenic granuloma. Thought to be reactive not neoplastic so not cancerous. gingival mass with islands of calcified material (from periosteum)
