Exam 3 Flashcards
final exam material
Effects of one drug interacts with the effects of another drug; usually a multiplier effect
Potentiation
State of decreased sensitivity to a drug’s effects resulting from prior exposure
Drug tolerance
Daily changes (~24 hrs); e.g. human sleep-wake cycles
Endogenous circadian rhythms
Species capable of generating body heat internally (e.g. mammals); cooling> evaporation (sweat), heating> shivering
Endothermic/homeothermic
Input from temperature receptors in skin, organs, brain, immune system
Sends information to the hindbrain, which controls physiological mechanisms
Preoptic Area (POA)/ Anterior Hypothalamus (AH)
The behavioral manifestation of the underlying circadian rhythm
Chronotype
Main driver of rhythms for sleep and body temperature
Part of the hypothalamus, neurons inactive at night; begin to fire at dawn; fire steady pace all day
Suprachiasmatic Nucleus (SCN)
Small branch of optic nerve from retina to SCN, alters SCN’s setting; responds to average overall amount of light (not sudden changes)
Retinohypothalamic Path
Temporarily increased set point for body temperature;
directed by hypothalamus, adaptive to fight infection, any deviation causes activation of physiological mechanisms to keep homeostasis, increased temperature becomes the new normal
Fever
Motivation to eat
Hunger
Hormone released by the pineal gland; causes drowsiness,
release begins to increase 2-3 hours before bedtime
pineal gland directed by the SCN
Melatonin
Supply the body with energy/nutritional resources needed for survival
Eating
A state actively produced by the brain; characterized by decreased response to stimuli
Sleeping
Process of breaking down food and absorbing it into the body; GI tract
Digestion
Stage of sleep? Before sleep, alpha waves
Stage 1
Bacteria and other organisms within the GI tract
Gut Microbiome
Stage of sleep? Theta waves, K complex, sleep spindles
Stage 2
Tolerance to the effects of one drug that develops as the results of exposure to another drug that acts by the same mechanism
Cross Tolerance
Effects opposite of the drug, compensatory changes in brain tolerance, taking away the substance
Withdrawal
An increase in the sensitivity to a drug that develops as a result of exposure to the drug
Drug Sensitization
Tolerance effects are maximally expressed only when a drug is administered in the same situation in which it has previously been administered
Conditioned Drug Tolerance
Stimuli that regularly predict the administration of the drug cause preemptive compensatory change to occur in the brain
Conditioned Compensatory Responses
Lowers levels of blood-borne fuels in preparation for the influx (ceph. phase)
Minimize increased levels of blood-borne fuels by utilizing and storing (absp. phase)
Promotes use of glucose as a primary source of energy
Insulin
Temperature regulation and other processes that keep body variables within a fixed range
Homeostasis
A single value/narrow range that the body strives to maintain
Set Point
Species active during the day, sleep at night
Diurnal