Exam 3 Flashcards
Inflammation
an immunologic defense against tissue injury, infection, or allergy
First outcome
Involves acute inflammation and restitution
Best possible outcome
(ex-sprained ankle)
Acute inflammation
initial response to injury
Focus is to eradicate dead tissue and protect against infection
Restitution
damaged tissue is replaced by identical tissue
Second outcome
fibrous repair of the damaged tissue and formation of scar tissue
Substantial tissue damage (ex-burn)
Third outcome
development of chronic inflammation;
pathologic agent remains active;
tissue destruction continues;
high outcome of morbidity and mortality
Fourth outcome
death of tissue and death of host
worst possible outcome
What are the outward signs of acute inflammation?
5 cardinal signs:
redness, swelling, heat, pain, loss of function
Physiologic changes of acute inflammation
increased blood flow;
migration of leukocytes from the blood to the tissues;
proteins, fluids, lymphocytes, monocytes, macrophages, granulocytes
Chronic inflammation
continues for weeks to years, never really goes away;
a granuloma is formed
Granuloma
at the site of an injury: an accumulation of macrophages, fibroblasts and collagen
Important history to assess for inflammation?
What was the trigger? -exposure to allergens -exposure to infectious agents -recent injury Risk factors: very young, very old, immunocompromised Physiological ability to respond Symptoms and duration Treatment up to the point of diagnosis
Internal signs of inflammation
fever, increased WBC, slowing/absence of tissue/organ function
Labs for inflammation
WBC with differential
C-reactive protein (CRP)
Erythrocyte sedimentation rate (ESR)
C-reactive protein (CRP)
elevation tells us that there is presence of inflammation;
marker for cardiac disease
Erythrocyte sedimentation rate (ESR)
refereed to as esedrate;
elevation indicates presence of inflammation
Epstein-Barr
virus that causes mononutriosis
C-diff
3 loose stools confirm presence;
needs protective isolation
H.pylori
microorganism;
antibiotic 7-10 days and ulcer is gone
Primary prevention of inflammation
hand hygiene, clean wounds, safety equipment in sports (helmets, padding), food and water safety standards