Exam 3 Flashcards
Chorionic Gonadotrophin (CG)
- created/secreted by the placenta to keep progesterone high
- acts similar to LH
- prevents miscarriage
Estrogen/Progesterone during pregnancy
- comes from placenta, not ovary
- if ovaries are removed during pregnancy, pregnancy still goes to term
Corticotrophin releasing hormone (CRH)
- created/secreted by the placenta
- controls release of cortisol
Who makes placenta
Fetus
Placenta is a major _____ and ______ _____
endocrine and immune gland
Antibody transfer before and after birth
- maternal antibodies cross placenta increasingly as pregnancy progresses
- after birth, passive immunity through breast milk for 3 months
- after 3 months, infant makes more IgGs on own
Placenta filters antibodies
- receptors on placenta that grab mother’s IgGs and pull them across placenta
Neotnatal IgGs level pattern
- highest in humans (~130% of mother), lesser as more primitive
Placental Iron Transfer
- receptors for iron
- ~50% of iron needed for baby to grow is pulled across placenta
Receptor for Iron
- transferrin
- If low iron transfer…
- then low iron stores
- insufficient iron for post-natal growth
- anemic
Obstetrical practice to make up for low iron
- delayed cord clamping
- blood goes into baby
- some humans eat placenta in form of pill, high in nutrients
Egg laying mammals
monotremes
mammals like marsupials
therian
live young
viviparity
true placental mammals
eutherian
immature
altricial
relatively mature
precocial
- prolongation of pregnancy and nursing
Nursing of primates
- lemurs 2-6 months
- monkeys 6-12 months
- apes 3-4 years
baby parking
galagos & mouse lemurs
nest or branch
Titi monkey
- monogamous
- paternal care
- NW
Aunting behavior
- squirrel monkey
- moms carrying
- older daughter also helps to carry sometimes
- pre puberty - females rush to baby if left alone
Baby Passing
- langurs
- for bonding?
- baby passed around amongst other females
- not always gentle
- dominant sometimes takes baby away from submissive mom
Immediately after birth…
mom pulls baby onto chest
Maternal Motivation
- predisposed to form selective bonds
- agitation reaction to involuntary separation
- permissive hormones
- birthing process (delivery/placenta)
- socialization
- elicitors
Elicitors
cues
Permissive Hormone
Oxytocin
If monkeys are delivered by C-section
- if cleaned, mother does not feel maternal bond
How does the mother know its a baby
- size
- smell
- natal coat
- “cute” response
- distress calls (cry)
What does baby bring to relationship?
- companionship
- grasping/clasping
- rooting/suckling
- negative geotropism
negative geotropism
- need to know up from down
3 primary stages in Mother-Infant Relationship & length of time in monkeys and apes
- Support
- Ambivalence
- Rejection
- monkeys; 6 months
- apes: 3-4 years
Support
Carrying, Nursing
Ambivalence
baby moves off mother, mother nervous
Rejection
wean & reject baby if it doesn’t become independent on its own
Importance of early experience
- if disruption in early experiences, consequences of development
Approach/Leave Ratio
- scoring that says how much infant is leaving/mother is approaching
- tells how independent baby has become
Monkeys 6-12 months development
- monkey infant off mother to peer play group of same age
- important for normal development - change from support to independence fairly fast
Great Apes timeline for primary stages
Support: 1 year
Ambivalence: 2 years
Rejection & active weaning: 3-4 years
Mother is a ______ to the baby
- source of emotional security
- if not mother, inhibited/affected development
- acts as both emotional support and learning for survival
Primates are predisposed to be _____
social
Theory of attachment
- John Bowlby
- biological predisposition to want to form attachment and relationship
- born looking to find mom&dad
- references Konrad Lorenz and Harry Harlow
Konrad Lorenz
- imprinting
- when young birds born, predisposed to find parents
- 1st thing they see is “mom/dad”
- if mother isn’t around, imprint on first thing they see
Cranes in Baraboo
- cranes raised in captivity
- use small plane to teach cranes to migrate south for winter
Hippo attachment example
- lost mother, follows turtle
Monkeys and Prosimians: sense used for attachment
- do not rely as much on vision, more on smell
Harry Harlow
- UW comparative psychologist
- cloth surrogate mother vs. wire mother
- wire mother had food but baby monkey spent 80-90% of time on cloth mother
- contact comfort
- when monkey was scared with toy, ran to cloth mother
- will go around barriers to get to cloth mother
- cloth mom is bonded to monkeys
3 stages of response to separation (losing care provider) once bond is formed
- protest
- depressive
- social detachment
Protest response to separation
- agitation
- 1st hour to 1st day
- human equivalent to crying
Depressive response to separation
- conservation withdrawal
- quiet, turned inward
Social detachment to separation
- if parent returns, child is detached & avoidant
- more prominent in humans
Baby monkey call to get mother to return
- whooo call
Protest-agitation bodily responses
- crying
- HR, BP, cortisol all increased
- aroused
Depressive-withdrawal bodily responses
- body temp, norepinephrine decreased
- immunosuppressed
3 main neurotransmitters involved in separation
- serotonin (5HT)
- dopamine (DA)
- norepinephrine (NE)
- in hindbrain, axons project forward, influence how brain functions
During protest phase of separation neurotransmitter effects
- dopamine, serotonin, norepinephrine increased
- continued demand to release NE when separation is longer & longer
- those who cannot meet this demand are more withdrawn when parent returns
Hans Spitz
- Detachment
- Hospitalization syndrome
- “failure to thrive”
Hospitalization syndrome
- when raised in orphanage –> okay 1-2 years… after that becomes detached
Anna Freud
- Freud’s daughter
- detachment in orphans from WWII
- hard for them to form new relationships
Romanian Institutions Ceaucescu 1989
- 2% of children (100,000) raised in state nurseries
- birth control banned, many children abandoned by mothers
Neurodevelopmental disorders and psychiatric conditions (3)
- Orality & self-clasping
- Rocking
- emotionality
Neurodevelopmental disorders and psychiatric conditions: Orality and Self-clasping
- grab onto anything, including self
- fixated
Neurodevelopmental disorders and psychiatric conditions: Rocking
- repetitive, stereotypic behavior
- self-injurious behavior (SIB)
- reflective of children w/ autism
Neurodevelopmental disorders and psychiatric conditions: Emotionality
- increased emotional reactivity
- social disinterest/aggressiveness
- lack of empathy
- normally when one monkey is upset and another sees it, it will also feel upset
Self-injurious behavior
- SIB
- self biting
- unresponsive “motherless mothers” –> do not feel bonding towards infant and do not hold onto it
Effects of neurodevelopment disorders on brain chemistry & immune system
- low NE
- altered DA functioning
- abnormal motivation and rewards system
- immunosuppressed
Epigenetics
- genes can be affected by early life events
Bifido bacteria Lactobacilli
- babies need to nurse with breastmilk
- nursery-reared infant have different gut bacteria than breast milk fed
Treatment/Recovery of detached/neglected monkeys (4)
- needs to be before 1 year of age
- Peer-reared monkeys
- Playroom therapy
- grandparent therapy
- dog parent therapy
Treatment/Recovery of detached/neglected monkeys: Peer-reared monkeys
- “together-together”
- not a great solution, will just hold one another but do not develop autonomy necessarily
Treatment/Recovery of detached/neglected monkeys: Playroom Therapy
- nuclear family housing
- only infants to central play area, mothers stay in big cages
- turn out okay, but sooner the better
- learn to interact appropriately
Treatment/Recovery of detached/neglected monkeys: Grandparent Therapy
- older monkeys become surrogate mom/dad
- decent way of raising monkeys normally
Treatment/Recovery of detached/neglected monkeys: Dog parent therapy
- do not develop complex social relationships as an adult
Are there ethical issues with infant research?
- is it ethical to conduct research on infants?
- what rationals should be required & is it reasonable to follow traditional research
Research changed rearing procedures at zoos
- babies used to be put in nursery, now babies raised by mom
- also contributed to radical change in how children were raised throughout the world
- orphanages down, foster families and adoption up
Serotonin
- 5HT
- sleep/wake
- depression
Dopamine
- DA
- movement
- motivated behavior
- drug addiction
Norepinephrine
- NE
- arousal
- depression
Watson: Pre- WWII view of parenting
- don’t hold baby, will become spoiled
- scheduled feeding then, on-demand feeding now
Importance of tactile stimulation (3 researchers)
- Harry Harlow: contact comfort
- Konrad Lorenz: imprinting
- John Bowlby: attachment theory
Oscar
- orphan chimp adopted by male
- mother died of illness
- most cases infant would die
Antidepressants raise ______
- 5HT, DA, NE
Allele related to depression
- determines how efficient at making/uptaking serotonin
- efficient: long allele
- inefficient: short allele
- can be long-long, long-short, or short-short
Efficient allele for reuptake of serotonin
- long allele (dandelion)
Inefficient allele for repute of serotonin
- short allele (orchid)
Monkey see, monkey do
- why does a monkey imitate?
- mirror neurons? (cells that get us to copy)
Preferences in monkeys (2 examples)
- infant preference: prefer monkeys of own species
- Rhesus: preference for adult females over males
Selection Circus
- put monkey inside circular apparatus
- preferred/detected female monkey vs male
- also showed threatening face
- no run until 3 months of age
Stages of life
- Infancy- weaning
- Juvenile to puberty
- subadult to adolescence
- adult - start of reproduction
- aged - old age
Chimps life span
- infancy lasts 0-4 years of age
- juvenile 5-8 years of age
- puberty: f–> 10-12 yrs old, m –> 11-13 yrs old
- adult: f–> 12-14 years, m –> 14 years
Juveniles hang out in _____
- large same-aged groups
- distinct behaviors
- play behaviors
- high energy level
exuberance
high energy level
Play behaviors (3)
- solo play
- social play
- object play/environment explore
Why play?
- fun
- learn skill
- socialization
- behavioral plasticity
- energy expenditure
Defining “play”
- nonpurposeful
- repetitive
- incomplete elements
- exaggerated
- “play face”
- response of recipient
- out of context
Evolution of the smile
- related to play-face
- wrestling play (rough and tumble) (more common in males)
Gender differences in play
- type of play
- m more rough & tumble
- cessation of play
- f stop earlier
- extended male adolescence
- onset of reproduction
- emmigration
androgenize
- fetus turning male by exposure to testosterone
Experiment with XX exposed to androgen during fetal development
- hermaphroditic in appearance
- behave more like males
- gynecological problems
- polycystic ovarian syndrome (PCOS)
PCOS
polycystic ovarian syndrome
- experienced by female monkeys who were injected with androgen during time as fetus
Time from menarche to first birth
- about 1.5 years
time from testical enlargement to adult rank/leaving
- about 2 years
ways to measure hormones
- blood
- saliva (1/10)
- urine and feces (metabolites)
- hair (long term)
every species has distinctive appearance change when adult –> examples (2)
- cheek pads in orange
- blue scrotum in vervet
Old Age overview (captivity)
- frail, lose weight (~20 years)
- in captivity, live additional 10-20 years as monkeys
Old Age changes (5)
- behavioral
- physiological
- cognitive
- disease morbidity
- mortality
Aging research in primates
- develop geriatric illnesses like people when in captivity because they live longer
- eyes: cataracts
- bone: osteoporosis
- brain: alzheimers (symptoms), parkinsons
- immunity: immune senescence, lower vaccine efficacy
Match-to-sample task in old age
- teach and remember later
- do worse as they age
Biomarkers of aging
- appearance
- metabolic syndrome (wear & tear)
- oxidative metabolism
- illness of old age
benefits of calorie restriction in captivity
- slower aging process
Brain maturation of monkeys (age)
- males: 5 years
- females: 3 years
flu vaccine response (age differences)
- antibody response lower in older monkeys
- gave second booster
- old & young increased response
Old monkeys do not experience dementia and alzheimers, however….
- they do lose neurons and develop plaques.
Experiment with flashing lights
- tests short term/working memory in old monkeys
- monkeys look through panel with 9 lights, they flash, have to remember where they are after time delays
- found short term memory is declining as expected
George Romanes (1884)
- “animal intelligence”
- argued curiosity, insight, empathy aspects of behavior are part of intelligence
Wilhelm Von Osten
- Clever Hans horse in carnival that could “count”
- horse really taking subliminal cues from owner
- we THINK the animal knows more than it does
Occam’s Razor
- do not make more complicated than necessary
- law of parsimony
Edward Thorndike
- Trial & error learning, no deep understanding
- reinforced by what works, conditioned
Pavlov
- classical conditioning
- stimulus, response
B.F. Skinner
- operant conditioning
- reinforcement with reward
Wolfgang Kohler
- “insight learning”
- gestalt psychology
- argued more than trial & error
- chimps have insight