Exam 3 Flashcards
Versed
Midazolam
Benzodiazepine (GABA agonist)
rapid onset of action (Use for acute agitation)
T1/2 = 1-3 hrs
active metabolite
Prolonged sedation may occur (obese, CKD, low albumin)
Versed
Midazolam
Benzodiazepine (GABA agonist)
rapid onset of action (Use for acute agitation)
T1/2 = 1-3 hrs
active metabolite
Prolonged sedation may occur (obese, CKD, low albumin)
Valium
Diazepam Benzodiazepine (GABA agonist) rapid onset T1/2 = 20-80 hrs (NO CI) active metabolite Use for short term sedation or status epilepticus
Diprivan
Propofol
Anesthetic with sedative and amnesic properties
GABA agonist/NMDA antagonist
Ideal for short term sedation (extubation, monitoring neuro function )
Diprivan
Propofol
Anesthetic with sedative and amnesic properties
GABA agonist/NMDA antagonist
Ideal for short term sedation (extubation, monitoring neuro function )
Valium
Diazepam Benzodiazepine (GABA agonist) rapid onset T1/2 = 20-80 hrs (NO CI) active metabolite Use for short term sedation or status epilepticus
Ativan
Lorazepam
Benzodiazepine (GABA agonist)
T1/2 = 10-20 hrs
NO active metabolite (faster recovery from sedation)
IV formula contains propylene glycol –> acute renal failure
Less lipophilic (Slower onset, longer DOA)
Diprivan
Propofol
Anesthetic with sedative and amnesic properties
GABA agonist/NMDA antagonist
Ideal for short term sedation (extubation, monitoring neuro function )
Precedex
Dexmedetomidine
sedative with analgesic effects
No respiratory depression
Selective alpha-2 agonist (inhibits release of NE, decreases BP and HR)
Be prepared to administer analgesics when weaning pt
Do NOT use in pts with low MAP
Romazicon
Flumazemil
BZD reversal agent
GABA antagonist
Amidate
Etodimate GABA agonist Rapid, short term sedation Minimal respiratory and CV depression Uses: cardio version, airway procedures, minor invasive procedures ADE: N/V, myoclonus and convulsions
Ketalar
Ketamine
NMDA antagonist
Sedation, analgesia, and amnesia simultaneously
Uses: painful procedure of short duration (Burns, bone re-setting)
ADE: hallucinations, sialorrhea, Inc ICP, tonic-clonic seizures
Pentothal
Thiopental
barbiturate
Nembutal
Pentobarbital
barbiturate
Anectin
Succinylcholine - depolarizing neuromuscular blockade
Uses: intubation
Can’t use long term due to inc K levels, histamine release, malignant hyperthermia