Exam 3 Flashcards
What are the 4 functions of the mouth?
-Prehension
-Chewing(Mastication)
-Salivation
-Swallowing(deglutation)
What is at the end of the esophagus leading to the stomach?
Lower esophageal sphincter
How tight is the lower esophageal sphincter?
It’s pretty loose
3 Main areas of the stomach
-Fundus
-Corpus Body
-Antrum
3 Main Areas of the Small Intestine
-duodenum
-jejunum
-ileum
What does the corpus body secrete?
-Mucus
-Pepsinogen
-HCl
What does the Antrum secrete?
-Mucus
-Pepsinogen
-Gastrin
What is the Gastric Pit?
It is the opening into the lumen/intestine from the stomach
What is underneath the gastric pit?
The mucosal layer
What are the 2 main components of the mucosal layer
-gastric glands
-lymphoid tissue
What are groupings of lymphoid tissue referred to as?
Peyer’s Patches
What layer is beneath the muscularis
submucosa
Smooth muscle in stomach
-Oblique
-Circular
-Longitudinal
What kind of smooth muscle is only in the stomach?
Oblique Smooth Muscle
What is the enteric nervous system?
The enteric nervous system is a web of neurons that branch from through the gastrointestinal system
Cells in Gastric pits
-Mucous
-Parietal(Oxynotic Cells)
-Chief
-Endochromafin
-Endocrine
What are Parietal Cells also known as?
Oxynotic Cells
Kinds of mucous cells
Neck Cells and surface cells
What is secreted by parietal cells?
HCl and Intrinsic Factor
What is secreted by chief cells?
pepsinogen
What do endocrine cells secrete?
gastrin and somatostatin
what doe endochromafin cells secrete?
hist amine
How is the Large intestine connected to the small intestine?
Through the ileum
What does the Large intestine have instead of tubules?
Crypts
What are the 4 components of the Large intestine?
-Colon
-Cecum
-Rectum
-Anal Canal
Where is the sublingual and what is it?
An accessory digestive organ that is underneath the tongue
Where is the submandibular and where is it?
It’s an accessory digestive organ that is underneath the jaw
What is the parotids, where is it, and what does it do?
The parotids is an accessory digestive organ by the ears that secrete serous
What accessory digestive organ is unique to ruminants?
inferior molars
Layers of the intestinal wall Descending
-Villi Cells
-Lymph Nodules
-muscularis mucosa
-Submucosal glands
-Submucosal plexes
-Circular smooth muscle
-mycentric plexes
-long smooth muscle
What are the 4 functions of saliva?
-Lubricates food
-Initiates small amounts of polysacchardies by amylase
-dissolves food
-antibacterial actions
What is the main pancreatic duct in the exocrine pancreas?
Wirsung Duct
What is the accessory duct for the exocrine pancrease?
Duct of Santorni
What component is the exit for the bile duct?
sphincter of oddi
What is the pancreas tubloalveolar gland?
Alveoli that are comprised of acinar cells and duct cells
What do acinar cells do?
secrete digestive enzymes
What do the duct cells in the tubloalveolar gland?
secrete bicarbonate
why do duct cells secrete bicarbonate?
To regulate a more neutral pH
Where are the islets of langerhans
in the endocrine pancreas
function of islets of langerhans
secrete insulin and glucagon from groups of pancreatic cells
What organ filters old red blood cells to make bilirubin?
The liver
What organ processes and stores nutrients?
The liver
What is old red blood cells processed into in the liver?
Bilirubin
What organ synthesizes plasma proteins
LIver
Plasma proteins of the liver
-albumin
-clotting proteins
-angiotensin
-steroid binding proteins
What is the main function of the hepatic portal system
the hepatic portal system is specialized vasaculature in the liver deisgned to deliver absorbed nutrients to the liver for processing before they enter systemic circulation
Where does the hepatic portal system absorb nutrients from?
The small intestine
What carries nutrients from the small intestine to the hepatic portal system
mesentriv veins
What is hepatobilary circulation
movement of bile acids from the liver to the SI then back to the liver
What are the cells of the liver?
Hepatocytes
How are hepatocytes organized
into lobules
Where are lobules centered around?
The central vein
where do lobules empty into
into the hepatic vein
Portal Triad:
-Portal Vein
-Hepatic Artery
-Bile Duct
What does the hepatic artery function as
oxygenation of the liver
Where is the bile canaliculi a part of?
The bile duct, or portal triad
What does the bile canaliculi function as?
They are bile capillaries that recieve secreted bile form hepatocytes
What do salivary glands secrete?
Mucous and serous secretions
What is the function of amylase
to break down starch
What do parietal cells(oxynotic cells) secrete
HCl and Intrinsic Factor
Intrinsic factor complexes with___ and is then absorbed by the____
Vitamin B12, ileum
pH of HCl
0.8
How are we protected from low pH’s?
Mucus lining
What does the proton pump help the production of?
HCl
What can pepsin inhibit?
The proton pump
What does HCl reduce feric iron (Fe3+) to?
ferrous iron Fe2+
4 functions of HCl
-activates pepsin
-kills bacteria
-acid hydrolysis of proteins
-Helps with Feric iron (Fe3+) absorption
What is pepsinogen secreted by?
Chief Cells
How is pepsin made?
HCl converting pepsinogen
What is pepsin classified as?
aspartylprotase
What is a –protase?
Acts on proteins
Function of pepsin
-Cleaves aromatic amino acids
-Acts on proteins that are ingested
pH of pepsin
1.3-1.8
How does pepsin degrade proteins?
Through its low pH
Amino acids cleaved by pepsin?
-Phenlyamine
-Tryptophan
-Tyrosine
Endocrine Cells
-Gamma Cells
-Entereochromafin cells
-D Cells
What do gamma cells secrete?
Gastrin
function of gastrin
to stimulate HCl
What do enterochromafin cells secrete?
histomine
Function of histomine
stimulates HCl
What do D cells secrete?
somatostatin
Function of somatostatin
to inhibit HCl
Neural Control of GI Secretions function
Controls smooth muscle contractions
Smooth muscle contractions in GI
peristalitic contractions and rhythamic contractions
What are the sub components of the enteric nervous system?
submucosal plexus and mycentric plexus
How does CNS control sympathetic and parasympathetic processes of the GI
Through hormonal control
What kind of nutrients does the GI absorb?
Everything whether or not you need it or not
Is the GI controlled by nutrional state of the body or the volume of luminal contents?
It is governed by the volume of luminal contents.
What three phases control gastric secretions?
-Cephalic Phase
-Gastric Phase
-intestinal
What does the cephalic phase do>
Stimulates normal enteric activity
What increases during the gastric phase?
HCl and Gastrin
What is the gastric phase mediated by?
-Neural
-Chemical
-mechanical
When does the gastric phase occur?
Only when found in the stomach
Where is gastrin releasing peptide?
In the enteric nervous system
Hormones of the stomach…
-Gastrin
-Somatostatin
-Ach
When does intestinal phase occur?
through mechanical and chemical receptors chyme enters the duodenum
Entereogastric reflex
The duodenum ENS acts on gastrin through the myenteric plexus
What cells are secreted in the duodenal mucosa?
cholecystokinin(cck) and secretin
What are the main pancreatic secretions
-Proteases
-Lipase
-Amylase
-Nucleases
What enzymes are classified as proteases?
-Trypsin
-Chymotrypsin
-clastase
-carboxypeptidase
What are lipase amylase and nucleases classified as?
Zymogen
What does zymogen mean?
Inactive enzymes
What is tripsinogen converted to once in duodenum wall?
Trypsin
How is tripsinogen converted to trypsin?
Therough the process of cleaving (entereokinase)
How is trypsinogen converted to trypsin?
Through the process of cleaving (enterokinase)
What is chymotrypsinogen converted to?
chymotrypsin
How is chymotrypsinogen converted to chymotrypsin?
Through trypsin
What is procarboxypeptidase converted to?
carboxypeptidase
What are the two phases of pancreatic secretions?
Cephalic and gastric
What are bile salts a derivative of?
Cholesterol
What are the two bile salts?
Glyconolic and tahrocholic
What are the bile pigments?
bilirubin and bilioerdin
What are lecithins as a bile secretion?
its a membrane phospholipid derivative
what does secretin as part of bile?
-Stimulates bile salt generation
-Recycles our bile salts
Where are carbs proteins and lipids processed from greatest to least
duodenum > jejunum > ileum
Where is calcium iron and folate processed?
All three are processed in the duodenum however only calcium is processed in juojenum and ileum
What component of the SI are bile acids processed in?
Ileum
What breaks down proteins in the stomach?
pepsin
What breaks down proteins in the small intestine?
Trypsin
What breaks down proteins in the pancreas?
chymotrysin
In the pancreas what processes amino acids?
carboypeptidase
In the SI how are amino acids processed?
Through aminopeptidase
How do amino acids enter epithelial cells?
Through the apical membrane through Na coupling
Where do amino acids exit into after entering epithelial cells?
The basolateral membrane through Na independent transporter
What does GLUT 2 transport as part of the basolateral membrane?
All three monosacharides
At 6 months of age what closes?
Your gut
entereocytes have ____ capacity to ____ whole proteins
limited, phagocytic
90% of whole proteins are degraded by what?
lysosomal enzymes