Exam 3

Question 1

Types of acute leukemia

Answer 1

Lymphocytic (lymphoblastic) and Myelogenous (non-lymphocytic)

Question 2

Types of chronic leukemia

Answer 2

Lymphocytic and Myelogenous

Question 3

Hereditary risks for acute leukemia

Answer 3

Down’s syndrome, Fanconi’s anemia, Bloom’s syndrome, and primary immunodeficiency

Question 4

Environmental risks for acute leukemia

Answer 4

Radiation, Chemicals, Chemotherapy

Question 5

features of acute leukemia

Answer 5

Anemia, Leukocytosis, Thrombocytopenia, increased LDH, increased lysozyme, increased uric acid, increased B12/folate binding proteins, increased LFT’s and renal dysfunction

Question 6

AML with multilineage dysplasia

Answer 6

Dysplasia in >50% of cells of at least 2 lineages, chromosomal abnormalities similar to those found in MDS

Question 7

AML therapy-related, alkylating agents, radiation

Answer 7

Usually occur 5-6 years post-therapy, risk related to cumulative dose and patient age, Chromosomal abnormalities, some similar to MDS

Question 8

AML therapy-related, topoisomerase II inhibitors and anthracyclines

Answer 8

Occur 1-10 years post-therapy, chromosomal abnormalities, some of 11q23

Question 9

Acute leukemia subtyping

Answer 9

Bone and/or marrow aspirate morphology, cytochemistry, indirect immunofluorescence, flow cytometry immunophenotyping, clinical history, cytogenetics

Question 10

M0-AML with minimal differentation

Answer 10

,3% blasts MPO/SBB positive, blasts positive for myeloid antigens, blasts negative for lymphoid antigens

Question 11

M1-AML without maturation

Answer 11

> 3% blasts MPO/SBB positive, <10% promyelocytes plus mature granulocytes

Question 12

M2-AML with maturation

Answer 12

> 3% blasts MPO/SBB positive, >10% promyelocytes plus mature granulocytes

Question 13

M4-AML

Answer 13

> 20% blasts granulocytic, >20% blasts monocytic

Question 14

M5-Acute monoblastic (a) and monocytic (b) leukemia

Answer 14

> 80% leukemic cells monocytic, M5a-majority of monocytic cells are monoblasts, M5b-majority of monocytic cells are promyelocytes

Question 15

M6-Acute erythroid leukemia

Answer 15

> 50% of marrow cells erythroid, >20% nonerythroid cells myeloblasts, Variant: pure erythroid leukemia with >80% marrow cells immature erythroid cells with no significant myeloblastic component

Question 16

M7-Acute megakaryocytic leukemia

Answer 16

Blasts MPO/SBB-negative, >50% blasts megakaryocytic as determined by CD41a or CD61, Variant: AML/transient myeloproliferative disorder in Down’s syndrome