Exam 2 Week 4

Question 1

Maturation of B Cells - Changes/expressions

• Pro B Cell
• Pre B Cell
• Immature/Naive B Cell
• Mature B cell
• Activated B cell

BCR = B cell Receptor
- Occurs in the absence of _____

Answer 1

• Pro B Cell = VDJ + hypervariable regions
• Pre B Cell = (mu symbol) chains with light chain
• Immature/Naive B Cell = IgM
• Mature B cell = IgM + IgD
• Activated B cell = IgM

Note:
VDJ is heavy chain
VJ is light chain
Occurs in the absence of antigen

Question 2

Maturation of T lymphocytes
- Beta chain vs alpha chain

TCR = T cell Receptor
Occurs in the absence of _____

Answer 2

• Beta chain = VDJ regions
• Alpha chain = VJ Region
  Occurs in the absence of antigen

Note: Goldilocks phenomenon

Question 3

Maturation site of B Cell, T Cell, and NK Cell

Answer 3

B Cell = Bone marrow
T Cell = Thymus
NK Cell = thymus not required (bone marrow)

Question 4

Cytokines that help differentiate…

• Pre B cells
• Pre T cells
• NK precursors

Answer 4

• Pre B Cells = IL-3; IL-7
• Pre T Cells = IL-7
• NK Precursor = IL-12, IL-13, TNF

Question 5

HTLV-1

• Tax gene
• HBZ gene

Answer 5

Tax = transcriptional factor, oncogene => induced IL-2 
HBZ = viral protein that limits Tax activity. 

Tax = process going towards cancer, HBZ is there to maintain it

Note: CD4+ t cells containing integrated HTLV-1 provirus proliferates = CELL to CELL

Question 6

CD Markers = Pre B vs Mature B

Answer 6

cig-u => found on Pre and Mature B

sig-u => Found on Mature B

Question 7

Dohle Bodies + toxic granulation

Answer 7

Neutrophilia

Question 8

Tingible Body macrophages + Reactive follicular hyperplasia + whooping cough (from pertussis)

Answer 8

Lymphocytosis

Question 9

EBV

• Association with -Philia
• Screening Test

Answer 9

• Monophilia (all monocytes)
• Atypical Lymphs
• ## Monospot test = screening test