Exam #2 Vocabulary Flashcards
Triglyceride
principle ingested lipid, composed of glycerol (carbon backbone) and attached fatty acids (acyl group)
Triacylglycerol
principle ingested lipid, composed of glycerol (carbon backbone) and attached fatty acids (acyl group)
Free Fatty Acids (FFA)
Non-esterified fatty acids that are unasscoaited with a triglyceride or glycerol molecule, typically long-chained
Fatty Acyl
Non-esterified fatty acids that are unasscoaited with a triglyceride or glycerol molecule, typically long-chained)
Bile Emulsification
smal intestine process of lowering lipid droplet surface tension by bile salts so dispersion occurs
Lipolysis
process of triglyceride breakdown (hydrolysis) into glycerol and fatty acids, opposite of esterification
Lipase
enzyme catalyzing triglyceride breakdown (pancreatic, lipoprotein, hormone-sensitive)
Chylomicron
lipoprotein generated in intestinal epithelium from dietary lipid, transported to blood via lymphatics
Very-low-density-lipoprotein (VLDL)
liver product, transports triglycerids to adipose and muscle to maintain circulating lipid
Lipoprotein lipase (LPL)
endothelial enzyme catalyzing lipolysis of circulating triglycerides (chylomicrons and VLDL’s)
Fatty acid activation
process of attaching a CoA to a fatty acid, required step for storage or oxidation at the cost of two ATP
Esterification
process of building a triglyceridefrom glycerol phosphate and fatty-acyl CoA, opposite of lipolysis
Glycerol phosphate
form of glycerol used in esterification of fatty acids, product of DHAP hydrogenation
Hormone-sensitive lipase (HSL)
intracellular enzyme catalyzing lipolysis of stored triglycerides (adipost and muscle), has multiple stimuli
Albumin
blood plasma fatty acid transport protein produced by the liver
Fatty acid binding protein (surface)
membrane protein aiding fatty acid uptake across plasma membrane (FABPpm and sarcolemmal-FABP)
Fatty acid binding protein (cellular)
aids intracellular fatty acid transport (muscle-FABP)
Fatty acid translocase (FAT)
membrane-bound protein aiding in fatty acid transport, may work in conjunction with surface FABPs
Carnitine acyl-transferase I
outer-mitochondrial membrane enzyme, catalyzes acyl-carnitine formation (CAT I)
Carnitine
compound that helps transport fatty acids across the inner-mitochondrial membrane
Acyl-carnitine
Fatty acid form during transport across inner-mitochondrial membrane, product of CAT I
Carnitine translocase
inner mitochondrial protein shuttle that transports acyl-carnitine into and carnitine out of the matrix
Carnitine acyl-transferase II
inner-mitochondrial membrane enzyme, catalyzes acyl-carnitine dissociation (CAT II)
Beta-oxidation
series of four mitochondrial reactions catabolizing acyl-CoA (yields acetyl-CoA, NADH+, H+, and FADH2)
Acyltransferase
enzyme catalyzing esterificaiton (transfer of acyl groups onto glycerol phosphate), stimulated by insulin
Capillary density
concentration of capillary blood vessels per unit of muscle
Amino acid
organic compound comprised of an amine (NH3+) and carboxyl group (COO-), protein building block
Essential amino acids
amino acids not synthesized by the body, must be obtained from the diet
Nitrogen balance
equation relating dietary nutrition (protein) intake versus nutrition excretion
Transamination
reaction in which the amine group (NH3+) of an amino acid is transferred to a keto analog
Alanine
primary gluconeogenic amino acid, pyruvate amino analog released by skeletal muscle and taken up by the liver
Glutamate
Main skeletal muscle amino acid, involved in transamination with pyruvate, wundergoes liver deamination
α-ketoglutarate
kreb’s cycle intermediate, keto analog of glutamate
Glucose-alanine cycle
mechanism aiding in blood glucose homeostasis, released muscle alanine acts as gluconeogenic precursor