Exam 2 Start: Week 4 - Surgical Meds Flashcards
Prototype Drugs for Medicaitons r/t to Surgery
Nitrous Oxide
Isoflurane (Forane)
Propofol (Diprivan)
Fentanyl (Sublimaze)
Midazolam (Versed)
Procaine and Lidocaine
Rocuronium (Zemuron)
Succinylcholine (Anectine)
Balanced Anesthesia
Use of various combinations of medications for the best results to provide sleep, analgesia, elimination of certian reflexes and good muscular
No one drug can do all these things alone
What sort of effects do we want from anesthesia
Analgesia
Decreased LOC (Coma) / Amensia
Decrease Anxiety
Decrease Muscle Activity
Decrease Secretions / N/V
Get into system quickly and leave the system quickly
no one magic drugs all of these at the same time
What are the 3 types of Anesthetic Drugs and the 1 Adjunct Category
- Inhalation Anesthetics
- IV Anesthetics
- Local Anesthetics
1 Adjunct: Skeletal Muscle Relaxant
Inhalation Anesthetics
Anesthesia Drugs administered through the respiratory tract - dosage is dependent of many things, but can be controlled by anesthetist – both inhalation and exhalation
2 Subtypes of Inhalation Anesthetics
- Gaseous
2. Vaporous
Classification of Nitrous Oxide
“Laughing Gas”
Gaseous (Inhalation) General Anesthetic
Gaseous General Anesthetic
Type of Inhalation Anesthetics
ex: NO
Causes ANALGESIA, narcosis, and amnesia by depressing the CNS via GABA - however does not depress the CNS well like volatile anesthetics
GABA receptor agonist, opioid agonist
How does gaserous general anesthetic cause its depression of CNS effect
it is a GABA receptor agonist / opioid agonist
Narcosis
effects that narcotics / opioids cause
ex; Sedation, pain relief, sleepiness, less anxiety, etc.
The big benefit of nitrous oxide is what
Analgesia
Why is nitrous oxide enver used for long procedures?
It does not last lone, but it does have a HIGHLY ANALGESIC EFFECT
Anesthesia is more than analgesia, it effects…
CNS, sensation, movement, etc
there are differing levels of anesthesia
What is Nitrous Oxides potentcy
very potent - small amounts give the effect wanted
ADRs of Gaseous General Anesthesia (Nitrous Oxide)
Suprisingly free of major toxicities when given WITH OXYGEN
Does compress normal tissue oxygenation if balance between NO and O2 is not adequate
Toxic Suppression of CNS can occur
Post op N/V can occur (more so than other drugs)
Nitrous Oxide does not…
cause complete loss of consciousness
Gaseous General Anesthesia (Nitrous Oxides) greatest use?
An induction agent - gets a person to the state where you can do the procedure / induce the effects (analgesia in this case)
Gaseous General Anesthesia (nitrous oxide) must be given with what?
- MUST be given in combination with oxygen (at least 30% oxygen)
- Must be given with other agents except in very short procedures
Important Points about Nitrous Oxide (General Gaseous Anesthesia)
Strong Analgesic, Poor Anesthetic (Depressing CNS)
Some N/V
Better to give with O2 in good balance
General Volatile Anesthesia
Type of Inhalation Anesthetics
Not a gas, it is a liquid that is more soluble in blood, ICF, and fat tissue than gas
Not explosive
What does the high solubility of General Volatile Anesthesia mean
There is slower onset in induction and slower recovery
High solubility will allow tissues and blood concentrations to build up unless carefully titrated
Classification of Isoflurane (Forane)
Inhaled General Volatile Anesthetic
What is the action of volatile asthetic
Progressive depression of CNS (exact action unknown); GABA (inhibition) and glutamate receptor agonist
Suffix: “-ane”
General Volatile Anesthetics
Which inhalation classification is better for longer procedures
General Volatile Anesthetics
What is the important thing that general volatile anesthetics does in comparison to gaseous general anesthetics
Volatile Anesthetics will depress the CNS, but its not as good for Analgesia like gaseous general anesthesia
Why can Isoflurane be used in longer procedures
it can be titrated up or down depending on if it is going longer or if it is done quickly
What are some other effects (not ADR) that can occur from isoflurane (volatile general anesthesia)
Hypotension (from vasodilation, not cardiac output effects)
Respiration - less efficient exchange of gas - rapid and shallow respirations; respiratory depression
Muscle - some relaxation by central depression
Liver - depressed function
Stronger CNS depression leads to this stuff
Why is the metabolism of isoflurane so important to know about?
It is minimal and since it crosses the blood brain barrier it has the intense CNS depressive effects
What is the typical method of excretion for inhaled anesthetics
respiratory (exhaled breaths)
ADR of Volatile General Anesthesia
- Hypotension (from vasodilation)
- Significant respiratory depression
- can trigger malignant hyperthermia - especially in conjunction with succinylcholine
How does volatile general anesthesia (isoflurane) simplify tracheal intubation
relaxes the tracheal area and depresses the reflexes
If isoflurane (volatile general anesthesia) is given alone…
it is NOT a potent analgesic
Has some mild skeletal muscle relaxant effects (but IS uterine muscle relaxant)
So if you need an agent for quick induction and one for muscle relaxant - if used alone, however, you could see the patient going through the stages of anesthesia because of the slow onset
Patients may do what following coming out of volatile general anesthesia
they may shiver
Other Volatile General Anesthesia drugs (other than isoflurane) that are related
desflurane (Suprane)
sevoflurane (Ultane)
Intravenous Anesthetics
IV drugs
inhalation can be uncomfortable or claustrophobic so this may be used
Types of IV Anesthetics
Hypnotics
Narcotics
Neuroleptics
Benzodiazepine
Example Drug for Hypnotics
propofol (Diprivan)
Example Drug for Narcotics
fentanyl (Sublimaze)
Example Drug for Neuroleptics
like Ketamine
Example Drug for Benzodiazepine
midazolam (versed)
Advantages of IV Anesthetics
rapid pleasant induction
absence of explosive hazards
low incidence of postop N/V (but some still quite sensitive)
Disadvantages of IV Anesthetics
laryngospasm and bronchospasm (may need intubation)
hypotension
resp. depression
Uses for IV Anesthetics
induce and maintain general surgical anesthesia
basal anesthesia (low start and add on top of it
usually use short acting and ultra short acting barbiturates (sedating meds)
Narcotic use
What is the major difference between barbiturates and gaseous agents is ___
safety