Exam 2 Reverse Flashcards
Serum level dec. but total body sodium normalSevere1. Hyperglycemia2. Hyperproteinemia3. Hyperlipidemia
What is psuedohyponatermia & causes?
<113 - seizures & coma High mortality w/ CNS findings
S/S Hyponatremia
True hyponatremia - osmolality decFactitious hyponatremia - osmolality normal or inc.
Dx hyponatermia
Osmotic pressure >295MCC hyperglycemiaEach 100mg/dL inc. in glc dec. serum sodium by 1.7 due to water moving into ECF
Hypertonic hyponatermia
Osmotic pressure 275-295High proteins & lipids cause a lab to report a falsely lowered sodium than what the serum actually contains
Isotonic hyponatremia
Osmotic pressure >275 Hypovolemic - loss of Na & waterEuvolemic - normal volume statusHypervolemic - excess total body water
Hypotonic hyponatremia
Hypovolemic hyponatremiaUrinary sodium >201. Diuretics2. Renal tubular acidosis, chronic renal failure, nephritis3. Osmotic diuresis4. Addison’s
Causes of renal losses of sodium
Hypovolemic hyponatremiaUrinary sodium <201. Vol replacement w/ hypotonic fluids2. GI loss (V/D, tube suction)3. 3rd space loss (burns, peritonitis, pancreatitis)4. Sweating (CF)
Causes of extrarenal losses of sodium
Urinary sodium >201. SIADH - tumors, CNS disease, pulm disease, meds, idiopathic2. Hypothyroid3. Pain, stress, psychosis - stimulates ADH4. Drugs - carbamazepine, phenothiazines, TCAs5. Water intoxication6. Glucocorticoid deficiency
Euvolemic hyponatremia
Volume overload Urinary sodium >20 - renal failureUrinary sodium <20 - CHF, cirrhosis, nephrotic syndrome
Hypervolemic hyponatremia
Hypervolemic or euvolemic hyponatremia - fluid restriction SIADH - demeclocycline or furosemideHypovolemic hyponatremia - isotonic saline
Tx hyponatremia
Central pontine myelinolysis brain injury
What can happen if you correct hyponatremia too rapidly?
Give 3% hypertonic saline at 25-60 mL/hrDo not raise Na >2mEq/L/hrStop when sodium reaches 120 or when Pt improves
Acute Hyponatremia <120 w/ CNS Sx - how do you treat?
Correction of Na no more than 0.5 mEq/L/hr
Tx chronic hyponatremia
- Na <1252. Require IV3. Significant comorbidities
When do you admit hyponatremia Pts?
Na >1501. Reduced water intake2. Inc. water loss - hypervent., DI, osmotic diuresis, thyrotoxicosis, severe burns3. Inc. sodium intake/renal salt retention - hypertonic saline ingestion, sodium bicarb, hyperaldosteronism, Cushing’s
Hypernatremia causes
Usually at Na>158 - rate of change important1. Confusion, weakness, irritable, restless, tremulous, seizures, coma2. Hypocalcemia may be present causing CNS Sx3. Flat neck veins, orthostatic HOTN, tachycardia, poor skin turgor, dry mucous membranes
Sx hypernatremia
Severe dehydration - NS or LR Then 0.45% saline Sodium reduction should not exceed 15mEq/L/day Reach normal serum sodium in 48-72hrs
Tx hypernatremia
5-Mar
You lose 1L of water, how much does your serum sodium increase?
Hypokalemia - <3.5
What is the MC electrolyte abnormality?
- Extrarenal - inadequate intake, V/D, inc. insulin, alkalosis2. Renal - diuretics, aldosteronism, renal tubular acidosis3. Lithium, heavy exercise, heat stroke, fever
Causes of hypokalemia
- Weakness, paresthesias, polyuria, orthostatic HOTN, areflexia, ileus, arrhythmias 2. EKG - T wave flattening/inversion, U waves, ST depression, PVC’s, wide QRS, tachyarrhythmias Want to get CK, Mg, UA, BMP
S/S hypokalemia
K>2.5 w/o EKG findings - oral replacement daily until normalK<2.5
Tx hypokalemia
K >5.5 1. Factitious - release of intracellular K by hemolysis during phlebotomy2. Extrarenal causes - insulin deficiency, acidosis, hyperosmolality, beta-blockers, supplements, massive transfusion, crush injuries, burns, mesenteric or muscle infarction 3. Renal causes - chronic renal insufficiency, acute renal failure, hypoaldosteronism, drugs (NSAIDs, ACEi, K-sparing diuretics)
Hyperkalemia causes
Weakness, paresthesias, confusion, paralysis, areflexia, V/D, ileus, arrhythmias (VF, heart block, asystole)EKG changes6.5-7.5 - Prolonged PR, tall peaked T waves, short QT7.5-8 - Flattening of P wave, QRS widening10-12 - QRS complex degradation into a sinusoidal pattern
S/S hyperkalemia
- Albuterol 2. CaCl or gluconate 3. Sodium bicarb4. Insulin & glc5. Furosemide6. Dialysis 7. Kayexalate
Tx hyperkalemia
Ionized Ca
Causes of hypocalcemia
- Circumoral & distal extremity paresthesis2. Irritability, weakness, fatigue, muscle cramps3. Seizures 4. Hyperreflexia 5. Carpopedal spasm, tetany, laryngospasm6. Trousseau’s sign7. Chvostek’s sign 8. Prolonged QT9. Sinus bradycardia10. Heart block11. VT/VF
S/S hypocalcemia
Asymptomatic - oral therapyTx hypomagnesemia <1.3 or Sx - IV Cagluconate over 10 min then maintenance infusion-careful w/ Digoxin
Tx hypocalecemia
Total Ca > 10.5Ionized Ca >2.7 1. CA/hyperparathyroidism**2. Endocrine - hyperthyroidism, pheochromocytoma, adrenal insufficiency3. Granulomatous disorders - sarcoid, TB, histoplasmosis, coccidiomycosis4. Immobilization, Paget’s disease, dehydration, excess Ca ingestion, milk alkali syndrome
Hypercalcemia Causes
- Weakness, depression, confusion, lethargy, personality changes, N/V, anorexia, constipation, HA, abd pain2. Dehydation, dec. motor strength3. Dec. mental status4. Ataxia, hyporeflexia5. Fx6. HTN, wt loss, renal insufficiency, cardiac arrest7. Short QT, widened T waves, bradyarrhythmias, BBB, AV blocksStones, bones, moans & groans
S/S hypercalcemia
Any Sx Pt or total Ca >14 1. Vol replacement2. Furosemide3. Mithramycin 4. Pamidronate5. Calcitonin6. Hydrocortisone7. DialysisWatch hypokalemia & hypomagnesemia
Tx hypercalcemia
<11. Alcoholism2. Malnutrition3. Cirrhosis4. Pancreatitis5. Excessive GI fluid losses (Diarrhea)
Causes of hypomagnesemia
- Malaise2. Muscle weakness3. Anorexia, N/V4. Seizures 5. Chvostek & Trousseau’s6. Tremors, twitching, clonus, dec. DTR, carpopedal spasm, tetany, delirium, dysarthria 7. Tachyarrhythmias, Torsades, prolonged PR & QT
S/S hypomagnesemia
Mild - Mg(OH)2Severe - neuro findings & arrythmias - MgSO4 Admit if <1 & SxWatch hypokalemia, hypocalcemia, hypophosphatemia
Tx hypomagnesemia
> 2.5 - Rare - usually w/ renal failure/iatrogenic cause1. Rhabdo2. Tumor lysis3. Burns4. Trauma5. DKA6. Hypothyroid7. Antacids8. Laxative abuse9;. Eclampsia Tx
Hypermagnesemia Causes
Nonspecific1. N/V2. Lethargy, confusion3. Coma4. If >4 - Dec. DTR’s, muscle weakness, bulbar paralysis, resp. insufficiency
S/S hypermagnesemia
- Cagluconate/chloride2. Furosemide3. DialysisWatch hyperkalemia/hypercalcemia
Tx hypermagnesemia
- CNS lesions2. Sedative therapy & overdose3. Neuromuscular disorders4. Pleural disease5. COPD
Causes of resp. acidosis
- Anxiety - MCC2. Hypoxia3. Pulm. disorders4. Salicylate toxicity5. CNS disorders6. Pregnancy7. Early sepsis
Causes of resp. alkalosis
> 7.73
At what pH is there dec. cardiac function?
AlcoholMethanolUremiaDKAParaldehydeIron, IsoniaziedLactic acidosisEthylene glycolCarbon monoxideAspirinToluene
Causes of anion gap metabolic acidosis
Lactic acidosis - due to dec. oxygen to tissues, sepsis, shock
What is the MCC of anion gap met. acidosis?
- Conditions that cause renal loss of bicarb - renal tubular acidosis, acetazolamide therapy 2. Conditions that lead to GI loss of bicarb - diarrhea, pancreatic fistula, ureterosigmoidostomy3. HCl, ammonium chloride, oral CaCl2
Causes of nonanion gap metabolic acidosis
pH s respiration - rapid regular deep resp. rate
S/S met. acidosis
Na - (HCO3 - Cl)Normal is 10-12>12 - met. acidosis
Anion gap formula
- Tetany2. Seizures3. Loss of Ca, K & Mg
S/S met. alkalosis
Insulin
MCC hypoglycemia?
- Inadequate food intake2. Insulin/meds3. Drug interaction4. Infection5. Renal/hepatic failure6. ACS7. Stress
Causes of hypoglycemia
- Glucose D50W2. Glucagon 3. Octreotide - suppresses insulin secretionIf alcoholic - give thiamin to prevent Wernicke-Korsakoff’s syndrome
Tx hypoglycemia
Octreotide
Tx hypoglycemia cause by sulfonylurea?
- Not taking insulin2. Infection3. Pregnancy4. Hyperthyroidism5. Substance abuse (Cocaine)6. Meds - steroids, thiazides, antipsychotics, sympathomimetics 7. Heat-related illness8. CVA9. GI hemorrhage10. MI11. PE12. Pancreatitis13. Major trauma/surgery
Causes of DKA
- N/V, abd pain2. Polyuria, polydipsia3. AMS4. Kussmaul’s breathing5. Fruity breath6. Dehydration - HOTN, tachycardia, dry skin, dry mucous membranes
S/S DKA & HHS
- Glc >2502. Anion gap >103. Bicarb <7.35. Ketonemia
Labs DKA
- NS 2. Follow K+3. Insulin - 0.1/kg/hr
Tx DKA
Diabetics1. Stressor - infection, CVA, GI bleed, MI, pancreatitis2. Meds - thiazide diuretics, corticosteroids, lithium, beta-blockers, Ca-channel blockers, phenytoinNondiabetics 1. Severe dehydration/excess glucose load - burns, heat stroke, dialysis, diet, hyperalimentation
Causes of hyperosmolar hyperglycemia state
- Glc >6002. Osmolality >3153. Bicarb >154. pH >7. 3
Dx HHS
- IVF - correct 1/2 w/in 1st 12h then rest over next 24h 2. Once HOTN, tachycardia & urine output improve - switch to 0.45% NS 3. Potassium 4. Insulin
HHS Tx
Alcoholics who abruptly stop drinking after a binge or 1st time drinkers
Who gets alcoholic ketoacidosis?
Binge drinking then1. Abd pain - pancreatitis, gastritis, hepatitis2. N/V3. Alcohol withdrawal/DTs4. Dehydration - HOTN, tachycardia5. Kussmaul’s respiration6. +/- fever7. NL MS/coma8. Abd tenderness9. Heme + stool10. Hepatomegaly
S/S alcoholic ketoacidosis
- Low/NL/slightly inc. glc2. Wide anion gap met. acidosis3. +serum ketones
Dx alcoholic ketoacidosis
- Saline w/ glucose & thiamin 2. Insulin if DM3. Consider Mg & multivitamin 4. Bicarb if pH<7.1
Tx alcoholic ketoacidosis
Shortened bowel sundrome caused by bacterial fermentation
Type D lactic acidosis
Caused by tissue hypoxiaHas a high mortalityRelated to hemorrhagic, hypovolemic, cardiogenic & septic shock
Type A lactic acidosis
No tissue hypoxia - may be abrupt in onset or over a few hours Seen w/ DM, liver disease, seizures, renal disease, genetic disorders of metabolism, drugs (ethanol, metformin, salicylate ingestion)
Type B lactic acidosis
Produces anion gap acidosisAbrupt onset - ill Pt1. Hypoventilation or Kussmaul’s breathing2. Lethargy, coma3. Vomiting, abd pain
S/S lactic acidosis
- Ventilation & volume replacement2. Diuresis 3. Bicarb if pH<7.2 Admit to ICU
Tx lactic acidosis
- Infection - MCC2. Trauma, surgery, hyperosmolar coma3. DKA4. Withdrawal of thyroid med, iodine or contrast administration, thyroid gland palpation, ingestion of thyroid hormone, amiodarone, large doses of povidone-iodine w/ skin breakdown5. MI, CVA, PE6. Parturition (childbirth), eclampsia
Causes of thyroid storm
- Exopthalmos2. Widened pulse pressure3. +/- Palpable goiter4. Heat intolerance5. Fever6. Tachycardia out of proportion to fever7. Profuse sweating8. Dehydration9. Hair loss 10. Inc. SBP11. Inc. pulse pressure12. Systolic flow murmur13. Sinus tachycardia14. AFib, CHF, pulm. edema 15. Agitation, restlessness, psychosis, confusion, obtundation, coma, proximal muscle weakness, hyperreflexia16. Wt loss, N/V/D, anorexia, abd pain
S/S thyroid storm
- Inc. FT42. Suppressed unmeasureable TSH 3. Sinus tach/AFib
Dx thyroid storm
- IVF w/ dextrose 2. Oxygen3. Acetaminophen 4. Cooling blankets5. Cholestyramine6. Propylthiouracil/Methimazole7. Iodine, KI, NaI, Li8. Propranolol9. Hydrocortisone
Tx thyroid storm
Infection, cold, trauma, MI, CHF, CVA, GI bleed, surgery, burns Meds - beta-blockers, sedatives, narcotics, amiodarone MC in winter months in old ladies
Causes of myxedema coma
- Hypothermia2. Resp distress w/ hypoventilation, hypercapnia, hypoxia3. Cardiomegaly, vent arrhythmias, HOTN, bradycardia4. Seizures, ataxia, tremors, slow mentation, delusions, psychosis5. Megacolon, urinary retention, abd distention
S/S myxedema coma
- High TSH2. Low T43. Dec. Na & Cl 4. Hypoxia & hypercapnea
Dx myxedema coma
Tx before labs confirm Thyroid replacement therapySupportive care
Tx myxedema coma
- HOTN refractory to fluids & pressors2. Dehydation3. Weakness, lethargy4. Shock 5. Delirium6. Abd pain w/ N/V7. +/- sepsis
S/S adrenal crisis
- Hyponatremia2. Hypoglycemia3. Hypercalcemia4. Inc. BUN5. Mild met. acidosis 6. Flattened T waves, Prolonged QT & PR, low voltage, ST depression, signs of hypo/hyperkalemia
Dx adrenal crisis
- IVF2. Hydrocortisone3. Vasopressors
Tx adrenal crisis
Alcoholic w/ poor nutrition from thiamin deficiency PPTd by giving glucose to alcoholic w/ inadequate thiamin
Cause of Wernicke-Korsakoff’s syndrome
Triad1. AMS2. Opthalmoplegia3. Gait ataxia Also1. Hypothermia2. HOTN3. Coma4. Circulatory collapse
S/S Wernicke-Korsakoff
Usually made clinicallyTx immediately
Dx Wernicke-Korsakoff
- Thiamin2. Mg
Tx Wernicke-Korsakoffs
Ecchymosis of umbilicusFrom retroparitoneal hemorrhage from pancreatitis or trauma
What is Cullen’s sign & when is it seen?
Flank ecchymosisFrom retroperitoneal hemorrhage from pancreatitis or trauma
What is Turner’s sign & when is it seen?
Dilated veins around umbilicusSeen in liver disease
What is caput medusae & when is it seen?
Dilated bowel loops
Tympanic abdomen percussion means??
Could be cardiac or esophageal…needs more testing
Pt comes in w/ CP, given NTG & gets better. What was wrong?
- Carbonation - EZ gas2. IV glucagon - smooth muscle relaxer3. Acute endoscopy
Tx esophageal food bolus
Iatrogenic
MCC esophageal perforation?
Heard on heart ascultationDue to mediastinal emphysema
What is Hamman crunch & when is it seen?
- Pain acute, severe, diffuse, located in chest, neck, abd w/ radiation to back/shoulders2. Pain worse w/ swallowing3. HOTN4. Fever5. Abd rigidity6. Tachycardia, tachypnea CXR - mediastinal air, SQ emphysema, wide mediastinum, effusion
S/S esophageal perforation
- Chest CT/endoscopyTx 1. Shock resuscitation2. IV abx3. Surg. consult
Dx & Tx esophageal perforation
- Refusal to eat2. Inc. salivation3. Odynophagia4. Vomiting5. Choking6. Resp. Sx - stridor, cough, wheeze7. Neck or throat pain
S/S swallowed FB in kiddos
Distal to pylorus - d/c & wait to pass Obstruction? Emergent ednoscopy -button batters, perf, coin at cricopharyngeus muscle, >24h
Tx FB swallow
Can cause corrosion & perf…get XrayIf above pylorus - endoscopyIf passed - watch & f/u in 24h, repeat films in 48h
Swallowed button battery…what do you do??
Observe or whole bowel irrigationEndoscopy contraindicated - can rupture!
Tx body packers
- CXR - free air in 75%2. +/- CTTx 1. Labs - type & cross2. 2 large bore IVs3. O24. NG tube5. Broad spectrum abx6. Surg. consult
PUD Dx & Tx
PUD
MCC Upper GI bleed?
- PUD - epigastric pain, melena/hematemesis, stool +2. Variceal bleeding - painless, massive hematemesis, signs of chronic liver disease3. Mallory-weiss tear - Hx of forceful vomiting
Causes of upper GI bleeds
- 2 large bore IVs2. Transfusion of PRBCs3. PUD? IV PPI/H2 blocker4. +/- vasopressin 5. Mallory weiss tear? d/c after bleeding stops
Tx upper GI bleed
Viral gastroenteritis
MCC N/V?
Contains blood, mucus & pus
What is dysentery diarrhea?
Acute intestinal inflammation causing diarrhea w/ N/V
What is gastroenteritis?
- Salmonella2. Shigella3. Campylobacter4. Toxin producing E. coli
What should you suspect if you see systemic illness, fever & bloody stools?
BananasRiceApple sauceToastdiarrhea Pts
What is a BRAT diet & who should use it?
ex. LoperamideDon’t use w/ toxigenic gastroenteritis 1. Toxin producing E. coli2. Staph aureus3. Bacillus cereus4. C. diff
When should you avoid antidiarrheals?
No cramps, fever or fecal leukocytes Diarrhea goes away after meds stopped
S/S diarrhea caused by abx or other meds
VirusNorovirus
MCC infectious diarrhea
Clindamycinalso cephalosporings, PCN & fluoroquinolone
Which abx is most often assoc. w/ C. diff?
C. diff toxin in stoolColonoscopy? Yellowish plaques in lumenMild - monitorModerate - Flagyl for 10-14 daysSevere - hospitalize, Vanco PO x 10days
Dx & Tx C. diff
Feeling like you have to poop but your bowels are empty
What is tenesmus?
CT 1. Restore fluids & electrolytes2. NPO3. NG suction for obstruction, ileus, toxic megacolon4. Narcotics5. Abx
Dx & Tx Crohn’s & ulcerative colitis
- Antidiarrheals2. Hypokalemia3. Narcotics4. Cathartics 5. Pregnancy6. Enemas7. Recent colonoscopy Ulcerative colitis & Crohn’s at inc. risk
Causes of toxic megacolon
Adhesions from abdominal surgery2nd MCC? Incarceration of groin hernia
MCC small bowel obstruction??
CA2nd MCC? Diverticulitis
MCC large bowel obstruction?
Abd CT w/ contrast Xray - air fluid levels WBC >20k - gangrene, intra-abd abscess, peritonitisWBC >40k - mesenteric vasc. occlusion Inc. Hct, BUN & Cr - vol. depletion & dehydrationInc. urine spef. gravity, ketonuria, elevated lactate & met. acidosis - severe disease
Dx bowel obstruction
- Surg. consult2. NG tube if severe distention & vomiting 3. IVF
Tx bowel obstruction
- Closed-loop obstruction2. Bowel necrosis3. Cecal volvulus
Which types of bowel obstructions are surgical emergencies?
- IVF2. Observation
Tx adynamic ileus