exam 2 practice

Question 1

desirable characteristics for a peptide/protein drug

Answer 1

able to be self-administered by patient, high stability

Question 2

undesirable characteristics for a peptide/protein drug

Answer 2

high methionine content, high renal clearance

Question 3

2 components of a typical vector for protein drug expression

Answer 3

inducible promoter, gene of interest

Question 4

what’s true regarding AAV vectors

Answer 4

not highly toxic
cannot accommodate delivery of genes of any size
repeated delivery of AAVs can induce an immune response
AAVs have been used in some FDA approved products

Question 5

true w respect to challenges associated with RNAi delivery

Answer 5

unmodified siRNA and miRNA molecules are prone to rapid renal clearance and rapid enzymatic degradation

Question 6

capabilities of a chimeric antigen receptor T cell

Answer 6

antigen recognition
proliferation
co-stimulatory signaling activation
cytokine production

Question 7

true w respect to cell therapy biomanufacturing

Answer 7

allogeneic therapies are easier to scale-up and are generally less expensive + are subject to significant batch-to-batch variability + have more immunogenicity concerns than autologous therapies