Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Neuropharmacology > Exam 2 Pharmacology > Flashcards

Exam 2 Pharmacology Flashcards

1
Q

bioterpin

A

glycine transporter 1 antagonist

(increases NMDAR activity since NMDARs need glycine as a co-agonist, potential antipsychotic)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

N-methylglycine sarcosine

A

Glycine transporter 1 antagonist

(increases NMDAR activity since NMDARs need glycine as a co-agonist, potential antipsychotic)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

glycine, b-alanine, taurine, d and l-alanine, l-serine, d-serine

A

glycine receptor agonists

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

glycine receptor agonists

A

amino acids: glycine, b-alanine, taurine, d and l-alanine, l-serine, d-serine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

strychnine

A

competitive glycine receptor antagonist

a convulsant and pesticide, lethal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

picrotoxin and picrotin

A

noncompetitive inhibitors of alpha-homomeric glycine receptors and gaba a receptors

a convulsant, insecticide, antidote for barbituate poisoning in GABAA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

cyano-triphenyl-borate (CBT)

A

noncompetitive antagonist of alpha 2 homomeric glycine receptors, use-dependent meaning it binds in the open conformation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

vigabatrin

A

blocks gaba transaminase, meaning there is more GABA around

acts as an anticonvulsant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

tiagabine

A

GABA transporter inhibitor

anticonvulsant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

muscimol

A

GABA A agonist at the GABA site

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

bicuculline

A

GABAA antagonist at the GABA site

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

what do benzodiazepines, ethanol, and anaesthetics have in common

A

positive allosteric modulators of GABA A, potentiate GABA A current

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

benzodiazepines

A

potentiate the gaba a current, making it stronger

anxiolytic, anticonvulsant, sedative, alcohol detox

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

beta-carboline/ b-cce

A

inverse agonist of GABAA, binding at the benzodiazepine site

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

flumazenil

A

antagonist of GABAa at the benzodiazepine site, reverses the benzodiazepine overdose, reduces sleepiness

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

barbituates

A

bind gabaa on the beta subunit, potentiate GABAA current, sedatives/anxiolytics w/ high abuse potential

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

neurosteroids

A

allopregnanolone, ganaxalone

positive allosteric modulators of GABAa that act as anxiolytics or anticonvulsants

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

allopregnanolone, ganaxalone

A

positive allosteric modulators of GABAa that act as anxiolytics or anticonvulsants

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

anaesthetics

A

potentiate gabaA current

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

desflurane, isoflurane, sevoflurane

A

volatile anasthetics that potentiate gaba A current

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

propofol

A

intravenous anaesthetics that potentiate the GABA a current

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

ethanol

A

potentiates the GABAa current and can also weakly antagonize NMDARs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

baclofen

A

gaba b agonist

a muscle relaxant for spastic movement disorders and maybe alcoholism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

3-APPA

A

gabab agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

phaclofen

A

gabab r antagonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

nAchr agonists

A

acetylcholine, nicotine, carbachol, arecoline, coniine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

turbocurarine

A

nachr competitive reversible antagonist, active component of curare

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

varenicline

A

partial agonist at nachr receptors, helps with smoking quitting

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

mecamylmine

A

noncompetitive nachr antagonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

alpha-bungarotoxin

A

nachr antagonist– competitive and irreversible

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

muscarine

A

nonspecific agonist of machrs, causes salivation, sweating, tearing, diarrhea, cardiac/respiratory failure

antidote is atropine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

muscarinic agonists

A

muscarine, arecoline, oxotremorine, carbachol, pilocarpine

33
Q

tabun and sarin

A

gas acetylcholinesterase inhibitors

34
Q

diazinon

A

ache inhibitor

35
Q

carbamates and carbamyl

A

reversible covalent ache inhibitors

36
Q

physostigmine, rivastigmine, neostigmine

A

carbamate ache inhibitors, riva used for cns but neo isnt

37
Q

galantamine

A

ache inhibitor for dementia

38
Q

tacrine

A

ache inhibitor for dementia

39
Q

donzepil

A

ache inhibitor for dementia

40
Q

atropine

A

nonspecific competitive machr antagonist that counteracts muscarine and ache inhibitor poisoning

reduces salivation and diarrhea, counteracts bradycardia

41
Q

benzatropine

A

nonspecific competitive machr antagonist, reduces parkinsonism and tremors

42
Q

ampa receptor agonists

A

ampa, quisqualate, fluorowillardiine

43
Q

quisqualate

A

ampar agonist, also group 1 mglur agonist

44
Q

fluorowillardiine

A

ampar agonist

45
Q

nbqx

A

ampar competitive antagonist

46
Q

cnqx

A

ampar competitive antagonist

47
Q

dnqx

A

ampar competitive antagonist

48
Q

quinoxaline family

A

ampar competitive antagonist– NBQX, CNQX, DNQX

49
Q

tofisopram

A

noncompetitive antagonist of AMPAr

2,3 benzodiazepine

anticonvulsant, neuroprotective

50
Q

2,3 benzodiazepines

A

noncompetitive antagonist of ampar

anticonvulsant, neuroprotective

51
Q

iem 1460, spermine, philanthotoxin 74

A

bind glua2 lacking ampars, which can pass calcium

they block the ampa4 calcium current, and spermine helps give inward rectification to potassium channels

this is important because we can compare calcium passing and noncalcium passing channels

52
Q

cyclothiazide

A

blocks desensitization of AMPARs
a positive allosteric modulator

53
Q

ampakines

A

positive allosteric modulators of AMPA receptors. usually have CX and a number

can be nootropic

54
Q

aniracetam and piracetam

A

racetams that act as ampakines

ampakines are positive allosteric modulators of AMPA receptors

55
Q

benzylpiperidines

A

ampakines

they are positive allosteric modulators of AMPA receptors.

56
Q

families of drugs that are ampakines

A

racetams and benzylpiperdines

57
Q

cycloserine

A

partial NMDAR agonist at the glycine site

may help with cognitive symptoms of schizophrenia

58
Q

aspartic acid

A

NMDAR agonist at the glutamate site

59
Q

NMDAR agonists

A

NMDA, aspartic acid, cycloserine

60
Q

AP5

A

antagonist at glutamate site of NMDAR

61
Q

5,7 DCK

A

antagonist at glycine site of NMDAR

62
Q

MK801, Ketamine, PCP

A

use-dependent channel blockers of NMDARs

bind the open conformation, anesthetic, dissociative/hallucinogenic

63
Q

s-mcpg

A

mglur antagonist

64
Q

ACPD

A

mglur agonist for all families

65
Q

phenylglycines

A

family of mglur antagonists

66
Q

dhpg

A

group 1 mglur agonist

67
Q

mcpg

A

mglur group 1 antagonist

68
Q

aida

A

group 1 mglur antagonist

69
Q

cpccoet

A

mglur type 1 channel 1 noncompetitive antagonist

70
Q

mpep

A

mglur type 1 channel 5 noncompetitive antagonist

71
Q

mavoglurant

A

mglur type 1 channel 5 noncompetitive antagonist

failed fragile x clinical trials

72
Q

map4

A

group 2 and 3 mglur antagonist

73
Q

elgumegad and dcg iv

A

group 2 mglur agonist

addiction, anxiety, neuroprotective

74
Q

eglu, pccg4

A

group 2 mglur antagonists

75
Q

biphenylinadone A

A

positive allosteric modulator of group 2 mglur

anxiolytic, may be antipsychotic

76
Q

l-ap4

A

mglur group 3 agonist

77
Q

mppg

A

mglur group 3 antagonist

Neuropharmacology (2 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions