Exam 2 - Papillary Lesions Flashcards
T/F HPV is a double stranded RNA virus.
False it is an double stranded DNA virus
HPV infects ______ cells. Both cutaneous (face, hands and feet) and mucous membranes (oral cavity. head, neck and anogenital region)
epithelial cells
HPV
>____ types in humans
>___ types infect oral mucosa
200;30
T/F HPV is associated with benign, potentially malignant, and malignant epithelial lesions.
True
HPV Vaccine:
Became routine in ____
Currently ___-valent vaccine
Recommended for adolescent ________ yrs of age
Catch–up vaccine for those under _____
_____ doses ______ months apart
Became routine in 2006
Currently 9-valent vaccine
Recommended for adolescent 11-12 yrs of age
Catch–up vaccine for those under 26
2 doses 6-12 months apart
What does the HPV vaccine prevent?
Genital warts
Precancer and cancer of uterine, cervix, vulva, vagina, and anus
Oropharyngeal and other head and neck cancers
Oral/head and neck mucosa:
*Oral squamous papilloma HPV
Major HPV type?
HPV 6,11
Oral/head and neck mucosa:
*Oropharyngeal squamous cell carcinoma
Major HPV type?
HPV 16
Skin
*Verruca vulgaris
Major HPV type?
HPV 2
Anogenital region
*Condyloma acuminatum
Major HPV type?
HPV 6,11
What category does Squamous Papilloma fall under?
Infectious, neoplastic
Name the papillary pathology:
Tend to be stand alone
White or pink exophytic nodule with finger like surface projections
Often pedunculated
Squamous Papilloma
What papillary lesions that we talked about have
Benign proliferation/hyperplasia of stratified squamous?
- Squamous Papilloma
- Verruca Vulgaris
- Condyloma Acuminatum
Can be difficult to differentiate from one another
What are common locations to find Squamous Papilloma?
Soft palate, tongue, and lips are common oral sites
What age are squamous papillomas most likely to be found?
30-50 yrs olde
How do you tx squamous Papilloma?
Excisional biopsy
Tend to have a narrow base great practice for biopsying
LOW recurrence
What category does Verruca Vulgaris “common wart” fall under?
Infectious, neoplastic
T/F Verruca Vulgaris “common wart” is contagious.
TRUE!
What age group are you most likely to find Verruca Vulgaris?
Children
Name the lesion
Painless papule with papillary projections or rough, pebbly surface
Can have multiple or clustered lesions
Contagious
Verruca Vulgaris “common wart”
Where is Verruca Vulgaris “common wart” most commonly found?
Skin -
Orally -
Skin - hands
Orally - vermillion border, labial mucosa, and anterior tongue
How do you tx Verruca Vulgaris “common wart” on the skin?
Topical salicylic acid
Cryotherapy
How do you tx Verruca Vulgaris “common wart” orally?
Cryotherapy
Surgical excision (first line tx for oral lesions)
T/F Verruca Vulgaris “common wart” can resolve spontaneously.
True (2/3rd resolve within 2 years)
How long does it take for Verruca Vulgaris “common wart” to resolve spontaneously
2/3rd resolve within 2 years
What category does Condyloma Acuminatum fall under
Infectious - b/c thought of as a sexually transmitted disease
T/F Condyloma Acuminatum is contagious.
True
What papillary lesion did we talked about that is a common sedxually transmitted disease?
Condyloma Acuminatum
What demographic is Condyloma Acuminatum commonly found in?
Teenager and young adults
Condyloma Acuminatum is most commonly found __________.
Anogenital
Where are Condyloma Acuminatum lesions most frequently found orally?
labial mucosa and lingual frenum
Name the lesion:
Sessile, pink, exophytic mass with short, blunted surface projections
Tend to be larger than squamous papillomas
May be single or clustered
Condyloma Acuminatum
T/F Condyloma acuminatum is only found solitary.
False can be clustered or single
How do you tx Condyloma Acuminatum
Excisional biopsy
Cryotherapy and laser ablation also used
What category does inflammatory papillary hyperplasia fall under?
Injury
Describe etiology of Inflammatory papillary hyperplasia
Ill-fitting denture
Poor denture hygiene
Wearing denture 24 hours a day
Besides denture wearers Inflammatory papillary hyperplasia can also occur in pt with …..
high palatal vault and mouth breathers
Name the lesion:
Usually asymptomatic
Erythematous pebbly or papillary mucosa
Some have candidiasis some may not
Inflammatory papillary hyperplasia
How do you tx Inflammatory papillary hyperplasia?
Improve denture hygiene/remake ill-fitting denture
Topical and or systemic antifungal if indicated
